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Plasma total homocysteine levels, dietary vitamin B6 and folate intake in AD and healthy aging.
J Nutr Health Aging. 2003; 7(3):160-5.JN

Abstract

PURPOSE

To study the association between Alzheimer s disease (AD) and plasma total homocysteine (tHcy), dietary folate and vitamin B6.

METHODS

64 AD patients were matched by gender, age, and smoking status to 64 healthy controls. tHcy was determined using an automated immunoassay. Dietary patterns for three age periods (20-39, 40-59, and 60 + yrs) were assessed using a questionnaire adapted from the Block Health Habits and History Questionnaire. Respondents (cases by proxy) reported food frequencies, which were translated into estimated daily nutrient intakes. APOE genotype, cognitive performance (CDR, MMSE), blood lipids, and albumin were obtained for patients and controls.

RESULTS

tHcy did not differ significantly between controls (11.5 +/- 3.7 mmol/L) and AD patients (12.3 +/- 4.3 mmol/L)(p=0.25). tHcy levels were not related in AD patients or controls to education, CDR, MMSE, blood lipids, albumin or ApoE genotype (p>0.15). There was a negative correlation between plasma tHcy and triglyceride levels in AD patients (p=0.023), but not in controls. AD patients consumed significantly less dietary vitamin B6 (p=0.05) and folate (p=0.001) after age 60 than controls.

CONCLUSIONS

Although plasma tHcy levels were higher in cases than controls, this difference was not significant. tHcy levels were not related to cognitive status. Plasma tHcy was inversely correlated with triglyceride levels in AD patients but not in controls.

Authors+Show Affiliations

Mizrahi EH
Department of Neurology, School of Medicine, Case Western Reserve University, USA.
Jacobsen DW
No affiliation info available
Debanne SM
No affiliation info available
Traore F
No affiliation info available
Lerner AJ
No affiliation info available
Friedland RP
No affiliation info available
Petot GJ
No affiliation info available

MeSH

AdultAgingAlzheimer DiseaseApolipoproteins ECase-Control StudiesCholesterolEducational StatusFemaleFolic AcidGene FrequencyGenotypeHomocysteineHumansLogistic ModelsMaleMiddle AgedOdds RatioSerum AlbuminSmokingTriglyceridesVitamin B 6

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12766793

Citation

Mizrahi, E H., et al. "Plasma Total Homocysteine Levels, Dietary Vitamin B6 and Folate Intake in AD and Healthy Aging." The Journal of Nutrition, Health & Aging, vol. 7, no. 3, 2003, pp. 160-5.
Mizrahi EH, Jacobsen DW, Debanne SM, et al. Plasma total homocysteine levels, dietary vitamin B6 and folate intake in AD and healthy aging. J Nutr Health Aging. 2003;7(3):160-5.
Mizrahi, E. H., Jacobsen, D. W., Debanne, S. M., Traore, F., Lerner, A. J., Friedland, R. P., & Petot, G. J. (2003). Plasma total homocysteine levels, dietary vitamin B6 and folate intake in AD and healthy aging. The Journal of Nutrition, Health & Aging, 7(3), 160-5.
Mizrahi EH, et al. Plasma Total Homocysteine Levels, Dietary Vitamin B6 and Folate Intake in AD and Healthy Aging. J Nutr Health Aging. 2003;7(3):160-5. PubMed PMID: 12766793.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma total homocysteine levels, dietary vitamin B6 and folate intake in AD and healthy aging. AU - Mizrahi,E H, AU - Jacobsen,D W, AU - Debanne,S M, AU - Traore,F, AU - Lerner,A J, AU - Friedland,R P, AU - Petot,G J, PY - 2003/5/27/pubmed PY - 2003/9/27/medline PY - 2003/5/27/entrez SP - 160 EP - 5 JF - The journal of nutrition, health & aging JO - J Nutr Health Aging VL - 7 IS - 3 N2 - PURPOSE: To study the association between Alzheimer s disease (AD) and plasma total homocysteine (tHcy), dietary folate and vitamin B6. METHODS: 64 AD patients were matched by gender, age, and smoking status to 64 healthy controls. tHcy was determined using an automated immunoassay. Dietary patterns for three age periods (20-39, 40-59, and 60 + yrs) were assessed using a questionnaire adapted from the Block Health Habits and History Questionnaire. Respondents (cases by proxy) reported food frequencies, which were translated into estimated daily nutrient intakes. APOE genotype, cognitive performance (CDR, MMSE), blood lipids, and albumin were obtained for patients and controls. RESULTS: tHcy did not differ significantly between controls (11.5 +/- 3.7 mmol/L) and AD patients (12.3 +/- 4.3 mmol/L)(p=0.25). tHcy levels were not related in AD patients or controls to education, CDR, MMSE, blood lipids, albumin or ApoE genotype (p>0.15). There was a negative correlation between plasma tHcy and triglyceride levels in AD patients (p=0.023), but not in controls. AD patients consumed significantly less dietary vitamin B6 (p=0.05) and folate (p=0.001) after age 60 than controls. CONCLUSIONS: Although plasma tHcy levels were higher in cases than controls, this difference was not significant. tHcy levels were not related to cognitive status. Plasma tHcy was inversely correlated with triglyceride levels in AD patients but not in controls. SN - 1279-7707 UR - https://www.unboundmedicine.com/medline/citation/12766793/Plasma_total_homocysteine_levels_dietary_vitamin_B6_and_folate_intake_in_AD_and_healthy_aging_ DB - PRIME DP - Unbound Medicine ER -