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Effect of supplemental phytonutrients on impairment of the flow-mediated brachial artery vasoactivity after a single high-fat meal.
J Am Coll Cardiol 2003; 41(10):1744-9JACC

Abstract

OBJECTIVES

Our objective was to determine if long-term daily administration of phytonutrient supplements can prevent the immediate adverse impact of a high-fat meal and increase the production of nitric oxide.

BACKGROUND

Ingestion of a high-fat meal impairs flow-mediated vasodilation of the brachial artery for at least 4 h; however, co-ingestion of vitamin antioxidants or a green salad has been shown to prevent this effect.

METHODS

Flow-mediated brachial artery reactivity test (BART) both before and 3 h after a 900 calorie 50 g fat meal was evaluated in 38 healthy volunteers (age 36.4 +/- 10.1 years). Subjects were randomized to four weeks of daily supplementation with a powdered fruit vegetable juice concentrate (Juice Plus [JP]) along with a complex supplement providing nutritional antioxidants and various herbal extracts (Vineyard [V]), JP alone, or a matching placebo. At three and four weeks, BART was repeated both before and after the high-fat meal. Serum nitrate/nitrite concentrations were measured at baseline and at four weeks.

RESULTS

Four weeks of the JP-V combination blunted the detrimental effect of the high-fat meal (-47.5 +/- 23.4% at baseline vs. -1.7 +/- 9.7% at four weeks [p < 0.05]). Four weeks of JP alone had a similar beneficial effect (-45.1 +/- 19.7% at baseline vs. -16.6 +/- 10.3% at four weeks [p < 0.05]), whereas there was no substantial effect of the placebo. In the subjects treated with supplements, concentrations of serum nitrate/nitrite increased from 78 +/- 39 to 114 +/- 62 microm/l (p < 0.02).

CONCLUSIONS

Daily ingestion of modest amounts of a fruit/vegetable juice concentrate with or without adjunctive phytonutrient supplementation can reduce the immediate adverse impact of high-fat meals on flow-mediated vasoactivity and increase nitrate/nitrite blood concentration.

Authors+Show Affiliations

Cardiology Division, University of Maryland School of Medicine, Medical Center, 22 South Greene Street, Baltimore, MD 21201, USA. gplotnic@medicine.umaryland.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12767658

Citation

Plotnick, Gary D., et al. "Effect of Supplemental Phytonutrients On Impairment of the Flow-mediated Brachial Artery Vasoactivity After a Single High-fat Meal." Journal of the American College of Cardiology, vol. 41, no. 10, 2003, pp. 1744-9.
Plotnick GD, Corretti MC, Vogel RA, et al. Effect of supplemental phytonutrients on impairment of the flow-mediated brachial artery vasoactivity after a single high-fat meal. J Am Coll Cardiol. 2003;41(10):1744-9.
Plotnick, G. D., Corretti, M. C., Vogel, R. A., Hesslink, R., & Wise, J. A. (2003). Effect of supplemental phytonutrients on impairment of the flow-mediated brachial artery vasoactivity after a single high-fat meal. Journal of the American College of Cardiology, 41(10), pp. 1744-9.
Plotnick GD, et al. Effect of Supplemental Phytonutrients On Impairment of the Flow-mediated Brachial Artery Vasoactivity After a Single High-fat Meal. J Am Coll Cardiol. 2003 May 21;41(10):1744-9. PubMed PMID: 12767658.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of supplemental phytonutrients on impairment of the flow-mediated brachial artery vasoactivity after a single high-fat meal. AU - Plotnick,Gary D, AU - Corretti,Mary C, AU - Vogel,Robert A, AU - Hesslink,Robert,Jr AU - Wise,John A, PY - 2003/5/28/pubmed PY - 2003/6/11/medline PY - 2003/5/28/entrez SP - 1744 EP - 9 JF - Journal of the American College of Cardiology JO - J. Am. Coll. Cardiol. VL - 41 IS - 10 N2 - OBJECTIVES: Our objective was to determine if long-term daily administration of phytonutrient supplements can prevent the immediate adverse impact of a high-fat meal and increase the production of nitric oxide. BACKGROUND: Ingestion of a high-fat meal impairs flow-mediated vasodilation of the brachial artery for at least 4 h; however, co-ingestion of vitamin antioxidants or a green salad has been shown to prevent this effect. METHODS: Flow-mediated brachial artery reactivity test (BART) both before and 3 h after a 900 calorie 50 g fat meal was evaluated in 38 healthy volunteers (age 36.4 +/- 10.1 years). Subjects were randomized to four weeks of daily supplementation with a powdered fruit vegetable juice concentrate (Juice Plus [JP]) along with a complex supplement providing nutritional antioxidants and various herbal extracts (Vineyard [V]), JP alone, or a matching placebo. At three and four weeks, BART was repeated both before and after the high-fat meal. Serum nitrate/nitrite concentrations were measured at baseline and at four weeks. RESULTS: Four weeks of the JP-V combination blunted the detrimental effect of the high-fat meal (-47.5 +/- 23.4% at baseline vs. -1.7 +/- 9.7% at four weeks [p < 0.05]). Four weeks of JP alone had a similar beneficial effect (-45.1 +/- 19.7% at baseline vs. -16.6 +/- 10.3% at four weeks [p < 0.05]), whereas there was no substantial effect of the placebo. In the subjects treated with supplements, concentrations of serum nitrate/nitrite increased from 78 +/- 39 to 114 +/- 62 microm/l (p < 0.02). CONCLUSIONS: Daily ingestion of modest amounts of a fruit/vegetable juice concentrate with or without adjunctive phytonutrient supplementation can reduce the immediate adverse impact of high-fat meals on flow-mediated vasoactivity and increase nitrate/nitrite blood concentration. SN - 0735-1097 UR - https://www.unboundmedicine.com/medline/citation/12767658/Effect_of_supplemental_phytonutrients_on_impairment_of_the_flow_mediated_brachial_artery_vasoactivity_after_a_single_high_fat_meal_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735109703003024 DB - PRIME DP - Unbound Medicine ER -