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In-hospital mortality following acute exacerbations of chronic obstructive pulmonary disease.
Arch Intern Med 2003; 163(10):1180-6AI

Abstract

BACKGROUND

Acute exacerbations of chronic obstructive pulmonary disease (COPD) are a frequent cause of hospitalization in the United States. Previous studies of selected populations of patients with COPD have estimated in-hospital mortality to range from 4% to 30%. Our objective was to obtain a generalizable estimate of in-hospital mortality from acute exacerbation of COPD in the United States and to identify predictors of in-hospital mortality using administrative data.

METHODS

We performed a cross-sectional study utilizing the 1996 Nationwide Inpatient Sample, a data set of all hospitalizations from a 20% sample of nonfederal US hospitals. The study population included 71 130 patients aged 40 years or older with an acute exacerbation of COPD at hospital discharge. The primary outcome assessed was in-hospital mortality.

RESULTS

In-hospital mortality for patients with an acute exacerbation of COPD was 2.5%. Multivariable analyses identified older age, male sex, higher income, nonroutine admission sources, and more comorbid conditions as independent risk factors for in-hospital mortality.

CONCLUSIONS

Mortality during hospitalization in this nationwide sample of patients with acute exacerbations of COPD was lower than that of previous studies of select populations. This estimate should provide optimism to both clinicians and patients regarding prognoses from COPD exacerbations requiring hospitalization. Our results indicate that the use of administrative data can help to identify subsets of patients with acute exacerbations of COPD that are at higher risk of in-hospital mortality.

Authors+Show Affiliations

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 1830 E Monument Street, Suite 7110 A, Baltimore, MD 21205, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12767954

Citation

Patil, Susheel P., et al. "In-hospital Mortality Following Acute Exacerbations of Chronic Obstructive Pulmonary Disease." Archives of Internal Medicine, vol. 163, no. 10, 2003, pp. 1180-6.
Patil SP, Krishnan JA, Lechtzin N, et al. In-hospital mortality following acute exacerbations of chronic obstructive pulmonary disease. Arch Intern Med. 2003;163(10):1180-6.
Patil, S. P., Krishnan, J. A., Lechtzin, N., & Diette, G. B. (2003). In-hospital mortality following acute exacerbations of chronic obstructive pulmonary disease. Archives of Internal Medicine, 163(10), pp. 1180-6.
Patil SP, et al. In-hospital Mortality Following Acute Exacerbations of Chronic Obstructive Pulmonary Disease. Arch Intern Med. 2003 May 26;163(10):1180-6. PubMed PMID: 12767954.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In-hospital mortality following acute exacerbations of chronic obstructive pulmonary disease. AU - Patil,Susheel P, AU - Krishnan,Jerry A, AU - Lechtzin,Noah, AU - Diette,Gregory B, PY - 2003/5/28/pubmed PY - 2003/6/20/medline PY - 2003/5/28/entrez SP - 1180 EP - 6 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 163 IS - 10 N2 - BACKGROUND: Acute exacerbations of chronic obstructive pulmonary disease (COPD) are a frequent cause of hospitalization in the United States. Previous studies of selected populations of patients with COPD have estimated in-hospital mortality to range from 4% to 30%. Our objective was to obtain a generalizable estimate of in-hospital mortality from acute exacerbation of COPD in the United States and to identify predictors of in-hospital mortality using administrative data. METHODS: We performed a cross-sectional study utilizing the 1996 Nationwide Inpatient Sample, a data set of all hospitalizations from a 20% sample of nonfederal US hospitals. The study population included 71 130 patients aged 40 years or older with an acute exacerbation of COPD at hospital discharge. The primary outcome assessed was in-hospital mortality. RESULTS: In-hospital mortality for patients with an acute exacerbation of COPD was 2.5%. Multivariable analyses identified older age, male sex, higher income, nonroutine admission sources, and more comorbid conditions as independent risk factors for in-hospital mortality. CONCLUSIONS: Mortality during hospitalization in this nationwide sample of patients with acute exacerbations of COPD was lower than that of previous studies of select populations. This estimate should provide optimism to both clinicians and patients regarding prognoses from COPD exacerbations requiring hospitalization. Our results indicate that the use of administrative data can help to identify subsets of patients with acute exacerbations of COPD that are at higher risk of in-hospital mortality. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/12767954/In_hospital_mortality_following_acute_exacerbations_of_chronic_obstructive_pulmonary_disease_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/163/pg/1180 DB - PRIME DP - Unbound Medicine ER -