Tags

Type your tag names separated by a space and hit enter

Urinary N-acetyl-beta-D-glucosaminidase activity in type I diabetes mellitus.
Indian Pediatr 2003; 40(5):410-4IP

Abstract

We measured urinary albumin excretion rate (AER) and N-acetyl-beta-D-glucosaminidase (NAG) activity in relation to disease duration, acetylated hemoglobin (HbA1c), hypertension and puberty in 44 children and adolescents with type 1 diabetes mellitus. AER and Urinary NAG activity were significantly higher in the patients compared to controls (AER 19.4 +/-; 35.8 vs 4.7 +/- 4.4, NAG activity 5.6 +/- 0.6U vs. 1.6 +/- 0.2U). Microalbuminuria was present in seven patients (15.9%), all of whom were pubertal. There was no correlation between AER and urinary NAG activity. There was a significant direct correlation between AER and disease duration (P <0.05), HbA1c (P < 0.05), diastolic blood pressure (P <0.05) and puberty (P <0.05). None of the microalbuminuria related variables was significantly correlated with urinary NAG activity. Puberty was an independent factor for elevated urinary NAG activity. This study shows that urinary NAG is elevated in children and adolescents with type 1 diabetes mellitus, but is not associated with AER related factors except for puberty. Urinary NAG activity does not appear to be a useful marker for early detection of diabetic nephropathy in children and adolescents with type 1 diabetes mellitus.

Authors+Show Affiliations

Division of Pediatric Endocrinology and Metabolism, Cukurova University, Faculty of Medicine, Adana, Turkey. byuksel@mail.cu.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12768043

Citation

Mungan, N, et al. "Urinary N-acetyl-beta-D-glucosaminidase Activity in Type I Diabetes Mellitus." Indian Pediatrics, vol. 40, no. 5, 2003, pp. 410-4.
Mungan N, Yuksel B, Bakman M, et al. Urinary N-acetyl-beta-D-glucosaminidase activity in type I diabetes mellitus. Indian Pediatr. 2003;40(5):410-4.
Mungan, N., Yuksel, B., Bakman, M., Topaloglu, A. K., & Ozer, G. (2003). Urinary N-acetyl-beta-D-glucosaminidase activity in type I diabetes mellitus. Indian Pediatrics, 40(5), pp. 410-4.
Mungan N, et al. Urinary N-acetyl-beta-D-glucosaminidase Activity in Type I Diabetes Mellitus. Indian Pediatr. 2003;40(5):410-4. PubMed PMID: 12768043.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Urinary N-acetyl-beta-D-glucosaminidase activity in type I diabetes mellitus. AU - Mungan,N, AU - Yuksel,B, AU - Bakman,M, AU - Topaloglu,A K, AU - Ozer,G, PY - 2003/5/28/pubmed PY - 2003/6/24/medline PY - 2003/5/28/entrez SP - 410 EP - 4 JF - Indian pediatrics JO - Indian Pediatr VL - 40 IS - 5 N2 - We measured urinary albumin excretion rate (AER) and N-acetyl-beta-D-glucosaminidase (NAG) activity in relation to disease duration, acetylated hemoglobin (HbA1c), hypertension and puberty in 44 children and adolescents with type 1 diabetes mellitus. AER and Urinary NAG activity were significantly higher in the patients compared to controls (AER 19.4 +/-; 35.8 vs 4.7 +/- 4.4, NAG activity 5.6 +/- 0.6U vs. 1.6 +/- 0.2U). Microalbuminuria was present in seven patients (15.9%), all of whom were pubertal. There was no correlation between AER and urinary NAG activity. There was a significant direct correlation between AER and disease duration (P <0.05), HbA1c (P < 0.05), diastolic blood pressure (P <0.05) and puberty (P <0.05). None of the microalbuminuria related variables was significantly correlated with urinary NAG activity. Puberty was an independent factor for elevated urinary NAG activity. This study shows that urinary NAG is elevated in children and adolescents with type 1 diabetes mellitus, but is not associated with AER related factors except for puberty. Urinary NAG activity does not appear to be a useful marker for early detection of diabetic nephropathy in children and adolescents with type 1 diabetes mellitus. SN - 0019-6061 UR - https://www.unboundmedicine.com/medline/citation/12768043/Urinary_N_acetyl_beta_D_glucosaminidase_activity_in_type_I_diabetes_mellitus_ L2 - http://www.indianpediatrics.net/may2003/may-410-414.htm DB - PRIME DP - Unbound Medicine ER -