Tags

Type your tag names separated by a space and hit enter

Bone mass loss in calcium stone disease: focus on hypercalciuria and metabolic factors.
J Nephrol 2003 Mar-Apr; 16(2):260-6JN

Abstract

BACKGROUND

Several authors have observed that idiopathic calcium stone formers show a bone mass reduction, which is more evident in those with idiopathic hypercalciuria. The aim of this work was the evaluation of osteopenia and osteoporosis rate in a group of idiopathic calcium stone formers. The influence of hypercalciuria, nutritional factors and anthropometric parameters on bone mass was evaluated in these patients as well.

METHODS

We enrolled 196 idiopathic calcium stone formers; 102 males, and 94 females. All subjects underwent a metabolic study. BMC and BMD were evaluated as well as QUS.

RESULTS

Males showed greater weight, height, BMI, densitometric values and plasma creatinine, uric acid, urea, sodium, magnesium, GFR and urinary osmolarity than females. Moreover males excreted more uric acid, urea, creatinine, sulphate, phosphate, oxalate and citrate than females. The prevalence of osteopenia and osteoporosis, according to T-score, was 54% and 14% respectively. Hypercalciuria was demonstrated in 21.7% of the patients. Hypercalciuric men showed a higher excretion of urea, phosphate, sulphate and magnesium.

CONCLUSIONS

Our results confirm the importance of QUS in the evaluation of stone formers' bone mass. Anthropometric characteristics and dietary habits seem to play a role in bone loss. We did not demonstrate any influence of hypercalciuria on bone mass. Although the pathogenesis of bone loss in stone formers still remains unclear, it can be hypothesized that a slight degree of metabolic acidosis, probably of alimentary origin, may be involved in the reduction of bone mass.

Authors+Show Affiliations

Department of Nephrology, Dialysis and Kidney Transplant, Unit of Mineral Metabolism, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy. renataca@med.unibo.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

12768074

Citation

Caudarella, Renata, et al. "Bone Mass Loss in Calcium Stone Disease: Focus On Hypercalciuria and Metabolic Factors." Journal of Nephrology, vol. 16, no. 2, 2003, pp. 260-6.
Caudarella R, Vescini F, Buffa A, et al. Bone mass loss in calcium stone disease: focus on hypercalciuria and metabolic factors. J Nephrol. 2003;16(2):260-6.
Caudarella, R., Vescini, F., Buffa, A., Sinicropi, G., Rizzoli, E., La Manna, G., & Stefoni, S. (2003). Bone mass loss in calcium stone disease: focus on hypercalciuria and metabolic factors. Journal of Nephrology, 16(2), pp. 260-6.
Caudarella R, et al. Bone Mass Loss in Calcium Stone Disease: Focus On Hypercalciuria and Metabolic Factors. J Nephrol. 2003;16(2):260-6. PubMed PMID: 12768074.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone mass loss in calcium stone disease: focus on hypercalciuria and metabolic factors. AU - Caudarella,Renata, AU - Vescini,Fabio, AU - Buffa,Angela, AU - Sinicropi,Giuseppe, AU - Rizzoli,Elisabetta, AU - La Manna,Gaetano, AU - Stefoni,Sergio, PY - 2002/07/25/received PY - 2003/02/19/accepted PY - 2003/02/10/revised PY - 2003/5/28/pubmed PY - 2003/8/21/medline PY - 2003/5/28/entrez SP - 260 EP - 6 JF - Journal of nephrology JO - J. Nephrol. VL - 16 IS - 2 N2 - BACKGROUND: Several authors have observed that idiopathic calcium stone formers show a bone mass reduction, which is more evident in those with idiopathic hypercalciuria. The aim of this work was the evaluation of osteopenia and osteoporosis rate in a group of idiopathic calcium stone formers. The influence of hypercalciuria, nutritional factors and anthropometric parameters on bone mass was evaluated in these patients as well. METHODS: We enrolled 196 idiopathic calcium stone formers; 102 males, and 94 females. All subjects underwent a metabolic study. BMC and BMD were evaluated as well as QUS. RESULTS: Males showed greater weight, height, BMI, densitometric values and plasma creatinine, uric acid, urea, sodium, magnesium, GFR and urinary osmolarity than females. Moreover males excreted more uric acid, urea, creatinine, sulphate, phosphate, oxalate and citrate than females. The prevalence of osteopenia and osteoporosis, according to T-score, was 54% and 14% respectively. Hypercalciuria was demonstrated in 21.7% of the patients. Hypercalciuric men showed a higher excretion of urea, phosphate, sulphate and magnesium. CONCLUSIONS: Our results confirm the importance of QUS in the evaluation of stone formers' bone mass. Anthropometric characteristics and dietary habits seem to play a role in bone loss. We did not demonstrate any influence of hypercalciuria on bone mass. Although the pathogenesis of bone loss in stone formers still remains unclear, it can be hypothesized that a slight degree of metabolic acidosis, probably of alimentary origin, may be involved in the reduction of bone mass. SN - 1121-8428 UR - https://www.unboundmedicine.com/medline/citation/12768074/Bone_mass_loss_in_calcium_stone_disease:_focus_on_hypercalciuria_and_metabolic_factors_ L2 - https://medlineplus.gov/bonedensity.html DB - PRIME DP - Unbound Medicine ER -