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The influence of viral genotypes and rejection episodes on the recurrence of hepatitis C after liver transplantation.
Surg Today 2003; 33(6):421-5ST

Abstract

PURPOSE

The aim of this study was to report the influence of hepatitis C virus (HCV) genotype and rejection episodes on the outcome of orthotopic liver transplantation (OLT), hepatitis recurrence, and progression to graft cirrhosis after OLT.

METHODS

Fifty-three patients who all had undergone OLT for end-stage liver cirrhosis were selected for this study. Hepatitis C genotype was determined. Recurrent hepatitis and rejection were diagnosed based on elevated liver function tests and a liver biopsy.

RESULTS

The patients were followed up for a mean of 51.9 +/- 34.3 months. The cumulative survival rate was no different in OLT for hepatitis C and OLT for all other liver diseases. After OLT, serum HCV RNA was detected in 93%. Histological recurrence occurred in 85% of all patients. The 1-, 3-, and 5-year recurrence rates were 48%, 77%, and 85%, respectively. Of the 41 patients with recurrent hepatitis C, 4 (10%) had cirrhosis, 18 (44%) had hepatitis with fibrosis, and 91 (46%) had hepatitis without fibrosis at the end of follow-up. A total of 32% of the patients were infected by HCV genotype 1b and 68% by other HCV genotypes. The recurrence rates were significantly higher in patients infected with genotype 1b than in those with other genotypes (p = 0.04). Twenty of 48 patients (42%) experienced acute rejection. There was a strong association between the number of rejection episodes and the incidence of HCV-related cirrhosis (p < 0.01).

CONCLUSION

Our findings showed the genotype 1b to result in a higher recurrence rate after OLT. On the other hand, rejection episodes were associated with a more rapid progression to graft cirrhosis.

Authors+Show Affiliations

The Queensland Liver Transplant Service, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Qld 4102, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12768367

Citation

Sugo, Hiroyuki, et al. "The Influence of Viral Genotypes and Rejection Episodes On the Recurrence of Hepatitis C After Liver Transplantation." Surgery Today, vol. 33, no. 6, 2003, pp. 421-5.
Sugo H, Balderson GA, Crawford DH, et al. The influence of viral genotypes and rejection episodes on the recurrence of hepatitis C after liver transplantation. Surg Today. 2003;33(6):421-5.
Sugo, H., Balderson, G. A., Crawford, D. H., Fawcett, J., Lynch, S. V., Strong, R. W., & Futagawa, S. (2003). The influence of viral genotypes and rejection episodes on the recurrence of hepatitis C after liver transplantation. Surgery Today, 33(6), pp. 421-5.
Sugo H, et al. The Influence of Viral Genotypes and Rejection Episodes On the Recurrence of Hepatitis C After Liver Transplantation. Surg Today. 2003;33(6):421-5. PubMed PMID: 12768367.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of viral genotypes and rejection episodes on the recurrence of hepatitis C after liver transplantation. AU - Sugo,Hiroyuki, AU - Balderson,Glenda A, AU - Crawford,Darrell H G, AU - Fawcett,Jonathan, AU - Lynch,Stephen V, AU - Strong,Russell W, AU - Futagawa,Shunji, PY - 2003/5/28/pubmed PY - 2003/10/1/medline PY - 2003/5/28/entrez SP - 421 EP - 5 JF - Surgery today JO - Surg. Today VL - 33 IS - 6 N2 - PURPOSE: The aim of this study was to report the influence of hepatitis C virus (HCV) genotype and rejection episodes on the outcome of orthotopic liver transplantation (OLT), hepatitis recurrence, and progression to graft cirrhosis after OLT. METHODS: Fifty-three patients who all had undergone OLT for end-stage liver cirrhosis were selected for this study. Hepatitis C genotype was determined. Recurrent hepatitis and rejection were diagnosed based on elevated liver function tests and a liver biopsy. RESULTS: The patients were followed up for a mean of 51.9 +/- 34.3 months. The cumulative survival rate was no different in OLT for hepatitis C and OLT for all other liver diseases. After OLT, serum HCV RNA was detected in 93%. Histological recurrence occurred in 85% of all patients. The 1-, 3-, and 5-year recurrence rates were 48%, 77%, and 85%, respectively. Of the 41 patients with recurrent hepatitis C, 4 (10%) had cirrhosis, 18 (44%) had hepatitis with fibrosis, and 91 (46%) had hepatitis without fibrosis at the end of follow-up. A total of 32% of the patients were infected by HCV genotype 1b and 68% by other HCV genotypes. The recurrence rates were significantly higher in patients infected with genotype 1b than in those with other genotypes (p = 0.04). Twenty of 48 patients (42%) experienced acute rejection. There was a strong association between the number of rejection episodes and the incidence of HCV-related cirrhosis (p < 0.01). CONCLUSION: Our findings showed the genotype 1b to result in a higher recurrence rate after OLT. On the other hand, rejection episodes were associated with a more rapid progression to graft cirrhosis. SN - 0941-1291 UR - https://www.unboundmedicine.com/medline/citation/12768367/The_influence_of_viral_genotypes_and_rejection_episodes_on_the_recurrence_of_hepatitis_C_after_liver_transplantation_ L2 - https://dx.doi.org/10.1007/s10595-002-2537-5 DB - PRIME DP - Unbound Medicine ER -