Tags

Type your tag names separated by a space and hit enter

Association study of autoimmune thyroid disease at 5q23-q33 in Japanese patients.
J Hum Genet. 2003; 48(5):236-42.JH

Abstract

As part of a genome scan to locate familial Graves' disease (GD) and Hashimoto's thyroiditis (HT) genes, an autoimmune thyroid disease (AITD) susceptibility locus has recently been identified at 5q31-q33 in a Japanese population. We performed an association study using six microsatellite markers located at this locus in a set of 440 unrelated Japanese AITD patients and 218 Japanese controls. We found significant allelic association between AITD and three markers located in 5q23-q33. GD demonstrated significant associations with two of these markers, while HT did not show significant associations with any markers. Further, when patients with GD were stratified according to clinical manifestations, the association was significantly different from the other subgroup of each category. These findings suggest the presence of susceptible genes of AITD, especially distinct subgroups of GD, in or near 5q23-q33.

Authors+Show Affiliations

Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital, 54 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan. akataka@kuhp.kyoto-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12768441

Citation

Akamizu, Takashi, et al. "Association Study of Autoimmune Thyroid Disease at 5q23-q33 in Japanese Patients." Journal of Human Genetics, vol. 48, no. 5, 2003, pp. 236-42.
Akamizu T, Hiratani H, Ikegami S, et al. Association study of autoimmune thyroid disease at 5q23-q33 in Japanese patients. J Hum Genet. 2003;48(5):236-42.
Akamizu, T., Hiratani, H., Ikegami, S., Rich, S. S., & Bowden, D. W. (2003). Association study of autoimmune thyroid disease at 5q23-q33 in Japanese patients. Journal of Human Genetics, 48(5), 236-42.
Akamizu T, et al. Association Study of Autoimmune Thyroid Disease at 5q23-q33 in Japanese Patients. J Hum Genet. 2003;48(5):236-42. PubMed PMID: 12768441.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association study of autoimmune thyroid disease at 5q23-q33 in Japanese patients. AU - Akamizu,Takashi, AU - Hiratani,Hitomi, AU - Ikegami,Satoshi, AU - Rich,Stephen S, AU - Bowden,Donald W, Y1 - 2003/04/09/ PY - 2003/01/22/received PY - 2003/02/20/accepted PY - 2003/5/28/pubmed PY - 2003/8/23/medline PY - 2003/5/28/entrez SP - 236 EP - 42 JF - Journal of human genetics JO - J. Hum. Genet. VL - 48 IS - 5 N2 - As part of a genome scan to locate familial Graves' disease (GD) and Hashimoto's thyroiditis (HT) genes, an autoimmune thyroid disease (AITD) susceptibility locus has recently been identified at 5q31-q33 in a Japanese population. We performed an association study using six microsatellite markers located at this locus in a set of 440 unrelated Japanese AITD patients and 218 Japanese controls. We found significant allelic association between AITD and three markers located in 5q23-q33. GD demonstrated significant associations with two of these markers, while HT did not show significant associations with any markers. Further, when patients with GD were stratified according to clinical manifestations, the association was significantly different from the other subgroup of each category. These findings suggest the presence of susceptible genes of AITD, especially distinct subgroups of GD, in or near 5q23-q33. SN - 1434-5161 UR - https://www.unboundmedicine.com/medline/citation/12768441/Association_study_of_autoimmune_thyroid_disease_at_5q23_q33_in_Japanese_patients_ L2 - https://medlineplus.gov/autoimmunediseases.html DB - PRIME DP - Unbound Medicine ER -