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[GB virus C: lack of association with transaminases levels, CD4 and HIV viral load in aids patients].
An Med Interna. 2003 Apr; 20(4):175-8.AM

Abstract

OBJECTIVE

To study the prevalence of GBV-C-RNA in sera of HIV-infected patients and determine whether differences in immunological condition and hepatic disease exist between GBV-C positive and negative patients.

METHODS

The presence of GBV-C-RNA was determined in sera of 222 HIV-positive patients by semi-automated RT-PCR. A comparison of GBV-C-RNA positive and negative patients was made by studying a series of clinical and analytical parameters. This same comparison was made in particular between those coinfected with HCV and GBV-C and those who only presented GBV-C.

RESULTS

Prevalence of GBV-C-RNA was 28.8%. The most frequent hepatotropic virus was HCV, appearing in 71.6% of cases. Coinfection with HCV and HGV was present in 17% and 8.6% only had GBV-C. Patients positive for GBV-C-RNA showed clinical and analytical characteristics similar to those found in GBV-C-RNA negative patients. Among the HCV-GBV-C coinfected and those presenting HGV as the only virus it was observed that the coinfected group presented alterations in transaminases and predominance of parenteral transmission as a risk factor for HIV, whereas the GBV-C group presented normal transaminases and predominance of sexual transmission. No differences were perceived in mean CD4 and HIV-RNA values in both groups.

CONCLUSIONS

Being positive for GBV-C in HIV-positive patients does not influence the presence of hepatic disease that in these patients is frequently accompanied by coinfection with other hepatotropic viruses. Moreover, it does not seem to influence the viremia of the HIV nor the CD4 cell counts.

Authors+Show Affiliations

Servicio de Medicina Interna, Departamento de Medicina, Hospital Juan Canalejo, Universidad de A Coruña, A Coruña. lopez_calvo@cemiga.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

spa

PubMed ID

12768829

Citation

López Calvo, S, et al. "[GB Virus C: Lack of Association With Transaminases Levels, CD4 and HIV Viral Load in Aids Patients]." Anales De Medicina Interna (Madrid, Spain : 1984), vol. 20, no. 4, 2003, pp. 175-8.
López Calvo S, Vela A, Castro A, et al. [GB virus C: lack of association with transaminases levels, CD4 and HIV viral load in aids patients]. An Med Interna. 2003;20(4):175-8.
López Calvo, S., Vela, A., Castro, A., Cid, A., Aguilera, A., Vega, P., Hermida, M., Regueiro, B. J., & Pedreira, J. D. (2003). [GB virus C: lack of association with transaminases levels, CD4 and HIV viral load in aids patients]. Anales De Medicina Interna (Madrid, Spain : 1984), 20(4), 175-8.
López Calvo S, et al. [GB Virus C: Lack of Association With Transaminases Levels, CD4 and HIV Viral Load in Aids Patients]. An Med Interna. 2003;20(4):175-8. PubMed PMID: 12768829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [GB virus C: lack of association with transaminases levels, CD4 and HIV viral load in aids patients]. AU - López Calvo,S, AU - Vela,A, AU - Castro,A, AU - Cid,A, AU - Aguilera,A, AU - Vega,P, AU - Hermida,M, AU - Regueiro,B J, AU - Pedreira,J D, PY - 2003/5/29/pubmed PY - 2003/7/2/medline PY - 2003/5/29/entrez SP - 175 EP - 8 JF - Anales de medicina interna (Madrid, Spain : 1984) JO - An Med Interna VL - 20 IS - 4 N2 - OBJECTIVE: To study the prevalence of GBV-C-RNA in sera of HIV-infected patients and determine whether differences in immunological condition and hepatic disease exist between GBV-C positive and negative patients. METHODS: The presence of GBV-C-RNA was determined in sera of 222 HIV-positive patients by semi-automated RT-PCR. A comparison of GBV-C-RNA positive and negative patients was made by studying a series of clinical and analytical parameters. This same comparison was made in particular between those coinfected with HCV and GBV-C and those who only presented GBV-C. RESULTS: Prevalence of GBV-C-RNA was 28.8%. The most frequent hepatotropic virus was HCV, appearing in 71.6% of cases. Coinfection with HCV and HGV was present in 17% and 8.6% only had GBV-C. Patients positive for GBV-C-RNA showed clinical and analytical characteristics similar to those found in GBV-C-RNA negative patients. Among the HCV-GBV-C coinfected and those presenting HGV as the only virus it was observed that the coinfected group presented alterations in transaminases and predominance of parenteral transmission as a risk factor for HIV, whereas the GBV-C group presented normal transaminases and predominance of sexual transmission. No differences were perceived in mean CD4 and HIV-RNA values in both groups. CONCLUSIONS: Being positive for GBV-C in HIV-positive patients does not influence the presence of hepatic disease that in these patients is frequently accompanied by coinfection with other hepatotropic viruses. Moreover, it does not seem to influence the viremia of the HIV nor the CD4 cell counts. SN - 0212-7199 UR - https://www.unboundmedicine.com/medline/citation/12768829/[GB_virus_C:_lack_of_association_with_transaminases_levels_CD4_and_HIV_viral_load_in_aids_patients]_ L2 - http://www.diseaseinfosearch.org/result/279 DB - PRIME DP - Unbound Medicine ER -