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Biochemical and therapeutic effects of antioxidants in the treatment of Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.
Curr Drug Targets CNS Neurol Disord. 2003 Apr; 2(2):95-107.CD

Abstract

Aging is a major risk factor for neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). An unbalanced overproduction of reactive oxygen species (ROS) may give rise to oxidative stress which can induce neuronal damage, ultimately leading to neuronal death by apoptosis or necrosis. A large body of evidence indicates that oxidative stress is involved in the pathogenesis of AD, PD, and ALS. Several studies have shown that nutritional antioxidants (especially vitamin E and polyphenols) can block neuronal death in vitro, and may have therapeutic properties in animal models of neurodegenerative diseases including AD, PD, and ALS. Moreover, clinical data suggest that nutritional antioxidants might exert some protective effect against AD, PD, and ALS. In this paper, the biochemical mechanisms by which nutritional antioxidants can reduce or block neuronal death occurring in neurodegenerative disorders are reviewed. Particular emphasis will be given to the role played by the nuclear transcription factor -kB (NF-kB) in apoptosis, and in the pathogenesis of neurodegenerative disorders, such as AD, PD, and ALS. The effects of ROS and antioxidants on NF-kB function and their relevance in the pathophysiology of neurodegenerative diseases will also be examined.

Authors+Show Affiliations

Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, 66030 Santa Maria Imbaro (Chieti), Italy.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

12769802

Citation

Di Matteo, Vincenzo, and Ennio Esposito. "Biochemical and Therapeutic Effects of Antioxidants in the Treatment of Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis." Current Drug Targets. CNS and Neurological Disorders, vol. 2, no. 2, 2003, pp. 95-107.
Di Matteo V, Esposito E. Biochemical and therapeutic effects of antioxidants in the treatment of Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. Curr Drug Targets CNS Neurol Disord. 2003;2(2):95-107.
Di Matteo, V., & Esposito, E. (2003). Biochemical and therapeutic effects of antioxidants in the treatment of Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. Current Drug Targets. CNS and Neurological Disorders, 2(2), 95-107.
Di Matteo V, Esposito E. Biochemical and Therapeutic Effects of Antioxidants in the Treatment of Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis. Curr Drug Targets CNS Neurol Disord. 2003;2(2):95-107. PubMed PMID: 12769802.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biochemical and therapeutic effects of antioxidants in the treatment of Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. AU - Di Matteo,Vincenzo, AU - Esposito,Ennio, PY - 2003/5/29/pubmed PY - 2003/6/18/medline PY - 2003/5/29/entrez SP - 95 EP - 107 JF - Current drug targets. CNS and neurological disorders JO - Curr Drug Targets CNS Neurol Disord VL - 2 IS - 2 N2 - Aging is a major risk factor for neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). An unbalanced overproduction of reactive oxygen species (ROS) may give rise to oxidative stress which can induce neuronal damage, ultimately leading to neuronal death by apoptosis or necrosis. A large body of evidence indicates that oxidative stress is involved in the pathogenesis of AD, PD, and ALS. Several studies have shown that nutritional antioxidants (especially vitamin E and polyphenols) can block neuronal death in vitro, and may have therapeutic properties in animal models of neurodegenerative diseases including AD, PD, and ALS. Moreover, clinical data suggest that nutritional antioxidants might exert some protective effect against AD, PD, and ALS. In this paper, the biochemical mechanisms by which nutritional antioxidants can reduce or block neuronal death occurring in neurodegenerative disorders are reviewed. Particular emphasis will be given to the role played by the nuclear transcription factor -kB (NF-kB) in apoptosis, and in the pathogenesis of neurodegenerative disorders, such as AD, PD, and ALS. The effects of ROS and antioxidants on NF-kB function and their relevance in the pathophysiology of neurodegenerative diseases will also be examined. SN - 1568-007X UR - https://www.unboundmedicine.com/medline/citation/12769802/Biochemical_and_therapeutic_effects_of_antioxidants_in_the_treatment_of_Alzheimer's_disease_Parkinson's_disease_and_amyotrophic_lateral_sclerosis_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=1568-007X&volume=2&issue=2&spage=95&aulast=Di Matteo DB - PRIME DP - Unbound Medicine ER -