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Differential regurgitation in branch pulmonary arteries after repair of tetralogy of Fallot: a phase-contrast cine magnetic resonance study.
Circulation. 2003 Jun 17; 107(23):2938-43.Circ

Abstract

BACKGROUND

The importance of pulmonary regurgitation (PR) after repair of tetralogy of Fallot (TOF) is increasingly recognized, but little is known regarding its underlying mechanisms. This phase-contrast cine magnetic resonance (PC MR) study was performed to evaluate the relative contribution of each lung to total regurgitant volume.

METHODS AND RESULTS

Twenty-two patients with significant PR underwent a PC MR 3 to 16 years after repair of TOF. Regurgitant fraction of the main pulmonary artery was 39+/-10%. Regurgitant fraction of the left pulmonary artery (LPA; 46+/-18%) was greater than that of the right pulmonary artery (34+/-16%; P=0.002). The average contribution of the LPA to the total regurgitant flow volume was 54+/-19%, whereas its average contribution to the total forward flow volume was 44+/-13% (P=0.002). In 4 patients, regurgitant flow in the LPA accounted for 75% to 100% of the total regurgitant flow. There was a linear relationship between regurgitant fraction and fraction of the regurgitant flow duration in the main pulmonary artery (P<0.001) and right pulmonary artery (P=0.001) but not in the LPA (P=0.129).

CONCLUSIONS

PR after repair of TOF is commonly associated with differential regurgitation in the branch pulmonary arteries, which is usually greater in the LPA. Although the cause of this disparity requires further investigation, those patients with a significant unilateral contribution to total PR may be amenable to localized techniques to reduce regurgitation.

Authors+Show Affiliations

Department of Diagnostic Imaging, The University of Toronto School of Medicine, Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

12771012

Citation

Kang, I-Seok, et al. "Differential Regurgitation in Branch Pulmonary Arteries After Repair of Tetralogy of Fallot: a Phase-contrast Cine Magnetic Resonance Study." Circulation, vol. 107, no. 23, 2003, pp. 2938-43.
Kang IS, Redington AN, Benson LN, et al. Differential regurgitation in branch pulmonary arteries after repair of tetralogy of Fallot: a phase-contrast cine magnetic resonance study. Circulation. 2003;107(23):2938-43.
Kang, I. S., Redington, A. N., Benson, L. N., Macgowan, C., Valsangiacomo, E. R., Roman, K., Kellenberger, C. J., & Yoo, S. J. (2003). Differential regurgitation in branch pulmonary arteries after repair of tetralogy of Fallot: a phase-contrast cine magnetic resonance study. Circulation, 107(23), 2938-43.
Kang IS, et al. Differential Regurgitation in Branch Pulmonary Arteries After Repair of Tetralogy of Fallot: a Phase-contrast Cine Magnetic Resonance Study. Circulation. 2003 Jun 17;107(23):2938-43. PubMed PMID: 12771012.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential regurgitation in branch pulmonary arteries after repair of tetralogy of Fallot: a phase-contrast cine magnetic resonance study. AU - Kang,I-Seok, AU - Redington,Andrew N, AU - Benson,Leland N, AU - Macgowan,Christopher, AU - Valsangiacomo,Emanuela R, AU - Roman,Kevin, AU - Kellenberger,Christian J, AU - Yoo,Shi-Joon, Y1 - 2003/05/27/ PY - 2003/5/29/pubmed PY - 2003/7/2/medline PY - 2003/5/29/entrez SP - 2938 EP - 43 JF - Circulation JO - Circulation VL - 107 IS - 23 N2 - BACKGROUND: The importance of pulmonary regurgitation (PR) after repair of tetralogy of Fallot (TOF) is increasingly recognized, but little is known regarding its underlying mechanisms. This phase-contrast cine magnetic resonance (PC MR) study was performed to evaluate the relative contribution of each lung to total regurgitant volume. METHODS AND RESULTS: Twenty-two patients with significant PR underwent a PC MR 3 to 16 years after repair of TOF. Regurgitant fraction of the main pulmonary artery was 39+/-10%. Regurgitant fraction of the left pulmonary artery (LPA; 46+/-18%) was greater than that of the right pulmonary artery (34+/-16%; P=0.002). The average contribution of the LPA to the total regurgitant flow volume was 54+/-19%, whereas its average contribution to the total forward flow volume was 44+/-13% (P=0.002). In 4 patients, regurgitant flow in the LPA accounted for 75% to 100% of the total regurgitant flow. There was a linear relationship between regurgitant fraction and fraction of the regurgitant flow duration in the main pulmonary artery (P<0.001) and right pulmonary artery (P=0.001) but not in the LPA (P=0.129). CONCLUSIONS: PR after repair of TOF is commonly associated with differential regurgitation in the branch pulmonary arteries, which is usually greater in the LPA. Although the cause of this disparity requires further investigation, those patients with a significant unilateral contribution to total PR may be amenable to localized techniques to reduce regurgitation. SN - 1524-4539 UR - https://www.unboundmedicine.com/medline/citation/12771012/Differential_regurgitation_in_branch_pulmonary_arteries_after_repair_of_tetralogy_of_Fallot:_a_phase_contrast_cine_magnetic_resonance_study_ L2 - https://www.ahajournals.org/doi/10.1161/01.CIR.0000077064.67790.5B?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -