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Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men.

Abstract

We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-I and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, particularly tomatoes. These patterns support the possibility that IGFs may mediate some diet-cancer associations.

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  • Authors+Show Affiliations

    ,

    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, UK. D.J.Gunnel@bristol.ac.uk

    , , , , , , , , ,

    Source

    British journal of cancer 88:11 2003 Jun 02 pg 1682-6

    MeSH

    Adult
    Aged
    Case-Control Studies
    Cross-Sectional Studies
    Diet
    Feeding Behavior
    Humans
    Insulin-Like Growth Factor Binding Protein 3
    Insulin-Like Growth Factor I
    Male
    Middle Aged
    Prostatic Neoplasms
    Risk Factors

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    12771980

    Citation

    Gunnell, D, et al. "Are Diet-prostate Cancer Associations Mediated By the IGF Axis? a Cross-sectional Analysis of Diet, IGF-I and IGFBP-3 in Healthy Middle-aged Men." British Journal of Cancer, vol. 88, no. 11, 2003, pp. 1682-6.
    Gunnell D, Oliver SE, Peters TJ, et al. Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men. Br J Cancer. 2003;88(11):1682-6.
    Gunnell, D., Oliver, S. E., Peters, T. J., Donovan, J. L., Persad, R., Maynard, M., ... Holly, J. M. (2003). Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men. British Journal of Cancer, 88(11), pp. 1682-6.
    Gunnell D, et al. Are Diet-prostate Cancer Associations Mediated By the IGF Axis? a Cross-sectional Analysis of Diet, IGF-I and IGFBP-3 in Healthy Middle-aged Men. Br J Cancer. 2003 Jun 2;88(11):1682-6. PubMed PMID: 12771980.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men. AU - Gunnell,D, AU - Oliver,S E, AU - Peters,T J, AU - Donovan,J L, AU - Persad,R, AU - Maynard,M, AU - Gillatt,D, AU - Pearce,A, AU - Hamdy,F C, AU - Neal,D E, AU - Holly,J M P, PY - 2003/5/29/pubmed PY - 2003/7/16/medline PY - 2003/5/29/entrez SP - 1682 EP - 6 JF - British journal of cancer JO - Br. J. Cancer VL - 88 IS - 11 N2 - We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-I and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, particularly tomatoes. These patterns support the possibility that IGFs may mediate some diet-cancer associations. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/12771980/full_citation L2 - http://dx.doi.org/10.1038/sj.bjc.6600946 DB - PRIME DP - Unbound Medicine ER -