Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men.
We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-I and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, particularly tomatoes. These patterns support the possibility that IGFs may mediate some diet-cancer associations.
Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, UK. D.J.Gunnel@bristol.ac.uk, , , , , , , , ,
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I
Pub Type(s)Comparative Study
Research Support, Non-U.S. Gov't