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Expression pattern of metalloproteinases and tissue inhibitors of matrix-metalloproteinases in cycling human endometrium.
Biol Reprod. 2003 Sep; 69(3):976-84.BR

Abstract

The cyclic growth, differentiation, and cell death of endometrium represents the most dynamic example of steroid-driven tissue turnover in human adults. Key effectors in these processes-matrix metalloproteinases (MMPs) and their specific inhibitors (TIMPs)-are regulated by ovarian steroids and, locally, by cytokines. We used reverse transcription-polymerase chain reaction to evaluate the expression of both transcriptionally regulated molecules such as estrogen receptor-alpha, progesterone receptor, and prolactin and a large array of MMPs and TIMPs (MMP-1, -2, -3, -7, -8, -9, -11, -12, -19, -26, MT1-MMP, MT2-MMP, MT3-MMP, TIMP-1, -2, -3). Altogether, three distinct patterns of MMP and two patterns of TIMP expression were detected in cycling endometrium: 1). MMPs restricted to the menstrual period (MMPs-1, -3, -8, -9, -12); 2). MMPs and TIMPs expressed throughout the cycle (MMP-2, MT1-MMP, MT2-MMP, MMP-19, TIMP-1, and TIMP-2); 3). MMPs predominantly expressed during the proliferative phase (MMP-7, MMP-11, MMP-26, and MT3-MMP); and 4). TIMP-3, which, contrary to the other TIMPs, shows significant modulations, with maximum expression during the late secretory and menstrual phases. These specific patterns of MMP expression associated with each phase of the cycle may point to specific roles in the processes of menstruation, housekeeping activities, angiogenesis, tissue growth, and extracellular matrix remodeling.

Authors+Show Affiliations

Departments of Tumor and Development Biology, Faculty of Medicine, University of Liége, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12773401

Citation

Goffin, Frédéric, et al. "Expression Pattern of Metalloproteinases and Tissue Inhibitors of Matrix-metalloproteinases in Cycling Human Endometrium." Biology of Reproduction, vol. 69, no. 3, 2003, pp. 976-84.
Goffin F, Munaut C, Frankenne F, et al. Expression pattern of metalloproteinases and tissue inhibitors of matrix-metalloproteinases in cycling human endometrium. Biol Reprod. 2003;69(3):976-84.
Goffin, F., Munaut, C., Frankenne, F., Perrier D'Hauterive, S., Béliard, A., Fridman, V., Nervo, P., Colige, A., & Foidart, J. M. (2003). Expression pattern of metalloproteinases and tissue inhibitors of matrix-metalloproteinases in cycling human endometrium. Biology of Reproduction, 69(3), 976-84.
Goffin F, et al. Expression Pattern of Metalloproteinases and Tissue Inhibitors of Matrix-metalloproteinases in Cycling Human Endometrium. Biol Reprod. 2003;69(3):976-84. PubMed PMID: 12773401.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expression pattern of metalloproteinases and tissue inhibitors of matrix-metalloproteinases in cycling human endometrium. AU - Goffin,Frédéric, AU - Munaut,Carine, AU - Frankenne,Francis, AU - Perrier D'Hauterive,Sophie, AU - Béliard,Aude, AU - Fridman,Viviana, AU - Nervo,Patricia, AU - Colige,Alain, AU - Foidart,Jean-Michel, Y1 - 2003/05/28/ PY - 2003/5/30/pubmed PY - 2004/5/21/medline PY - 2003/5/30/entrez SP - 976 EP - 84 JF - Biology of reproduction JO - Biol Reprod VL - 69 IS - 3 N2 - The cyclic growth, differentiation, and cell death of endometrium represents the most dynamic example of steroid-driven tissue turnover in human adults. Key effectors in these processes-matrix metalloproteinases (MMPs) and their specific inhibitors (TIMPs)-are regulated by ovarian steroids and, locally, by cytokines. We used reverse transcription-polymerase chain reaction to evaluate the expression of both transcriptionally regulated molecules such as estrogen receptor-alpha, progesterone receptor, and prolactin and a large array of MMPs and TIMPs (MMP-1, -2, -3, -7, -8, -9, -11, -12, -19, -26, MT1-MMP, MT2-MMP, MT3-MMP, TIMP-1, -2, -3). Altogether, three distinct patterns of MMP and two patterns of TIMP expression were detected in cycling endometrium: 1). MMPs restricted to the menstrual period (MMPs-1, -3, -8, -9, -12); 2). MMPs and TIMPs expressed throughout the cycle (MMP-2, MT1-MMP, MT2-MMP, MMP-19, TIMP-1, and TIMP-2); 3). MMPs predominantly expressed during the proliferative phase (MMP-7, MMP-11, MMP-26, and MT3-MMP); and 4). TIMP-3, which, contrary to the other TIMPs, shows significant modulations, with maximum expression during the late secretory and menstrual phases. These specific patterns of MMP expression associated with each phase of the cycle may point to specific roles in the processes of menstruation, housekeeping activities, angiogenesis, tissue growth, and extracellular matrix remodeling. SN - 0006-3363 UR - https://www.unboundmedicine.com/medline/citation/12773401/Expression_pattern_of_metalloproteinases_and_tissue_inhibitors_of_matrix_metalloproteinases_in_cycling_human_endometrium_ L2 - https://academic.oup.com/biolreprod/article-lookup/doi/10.1095/biolreprod.103.015933 DB - PRIME DP - Unbound Medicine ER -