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Successful second allogeneic peripheral blood stem cell transplantation and donor lymphocyte infusion in patients with relapsed acute leukemia using the same donors as for the initial allogeneic bone marrow transplantation.
Bone Marrow Transplant. 2003 Jun; 31(11):1057-9.BM

Abstract

We report the successful treatment of two acute lympho- blastic leukemia (ALL) patients who relapsed following allogeneic bone marrow transplantation (allo-BMT) with allogeneic peripheral blood sem cell transplantation(allo-PBSCT) and donor lymphocyte infusion (DLI) from the same HLA-identical related donors as those used for the first allo-BMT. The patients relapsed on days 154 and 351 from the initial allo-BMT, respectively. Since conventional reinduction chemotherapy failed, allo-PBSCT was undertaken while the patients were still myelosuppressed immediately after reinduction chemotherapy. To induce and/or enhance GVL effects following allo-PBSCT, we performed rapid tapering of CsA and added DLI. After allo-PBSCT and DLI, the patients maintained their complete remission at 55 and 48 months post allo-PBSCT, respectively. From these findings, allo-PBSCT and DLI may be a useful treatment strategy for acute leukemia relapsing after allo-BMT.

Authors+Show Affiliations

Department of Internal Medicine and Molecular Science, Osaka University Medical School, Yamadaoka 2-2, B5, Suita, 565-0871, Osaka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

12774060

Citation

Ishikawa, J, et al. "Successful Second Allogeneic Peripheral Blood Stem Cell Transplantation and Donor Lymphocyte Infusion in Patients With Relapsed Acute Leukemia Using the Same Donors as for the Initial Allogeneic Bone Marrow Transplantation." Bone Marrow Transplantation, vol. 31, no. 11, 2003, pp. 1057-9.
Ishikawa J, Maeda T, Kashiwagi H, et al. Successful second allogeneic peripheral blood stem cell transplantation and donor lymphocyte infusion in patients with relapsed acute leukemia using the same donors as for the initial allogeneic bone marrow transplantation. Bone Marrow Transplant. 2003;31(11):1057-9.
Ishikawa, J., Maeda, T., Kashiwagi, H., Yoshida, H., Takahashi, I., Kawamoto, S. I., Yamada, M., Kato, H., Nishiura, T., Tomiyama, Y., & Matsuzawa, Y. (2003). Successful second allogeneic peripheral blood stem cell transplantation and donor lymphocyte infusion in patients with relapsed acute leukemia using the same donors as for the initial allogeneic bone marrow transplantation. Bone Marrow Transplantation, 31(11), 1057-9.
Ishikawa J, et al. Successful Second Allogeneic Peripheral Blood Stem Cell Transplantation and Donor Lymphocyte Infusion in Patients With Relapsed Acute Leukemia Using the Same Donors as for the Initial Allogeneic Bone Marrow Transplantation. Bone Marrow Transplant. 2003;31(11):1057-9. PubMed PMID: 12774060.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Successful second allogeneic peripheral blood stem cell transplantation and donor lymphocyte infusion in patients with relapsed acute leukemia using the same donors as for the initial allogeneic bone marrow transplantation. AU - Ishikawa,J, AU - Maeda,T, AU - Kashiwagi,H, AU - Yoshida,H, AU - Takahashi,I, AU - Kawamoto,S-I, AU - Yamada,M, AU - Kato,H, AU - Nishiura,T, AU - Tomiyama,Y, AU - Matsuzawa,Y, PY - 2003/5/30/pubmed PY - 2004/1/24/medline PY - 2003/5/30/entrez SP - 1057 EP - 9 JF - Bone marrow transplantation JO - Bone Marrow Transplant VL - 31 IS - 11 N2 - We report the successful treatment of two acute lympho- blastic leukemia (ALL) patients who relapsed following allogeneic bone marrow transplantation (allo-BMT) with allogeneic peripheral blood sem cell transplantation(allo-PBSCT) and donor lymphocyte infusion (DLI) from the same HLA-identical related donors as those used for the first allo-BMT. The patients relapsed on days 154 and 351 from the initial allo-BMT, respectively. Since conventional reinduction chemotherapy failed, allo-PBSCT was undertaken while the patients were still myelosuppressed immediately after reinduction chemotherapy. To induce and/or enhance GVL effects following allo-PBSCT, we performed rapid tapering of CsA and added DLI. After allo-PBSCT and DLI, the patients maintained their complete remission at 55 and 48 months post allo-PBSCT, respectively. From these findings, allo-PBSCT and DLI may be a useful treatment strategy for acute leukemia relapsing after allo-BMT. SN - 0268-3369 UR - https://www.unboundmedicine.com/medline/citation/12774060/Successful_second_allogeneic_peripheral_blood_stem_cell_transplantation_and_donor_lymphocyte_infusion_in_patients_with_relapsed_acute_leukemia_using_the_same_donors_as_for_the_initial_allogeneic_bone_marrow_transplantation_ L2 - https://doi.org/10.1038/sj.bmt.1704059 DB - PRIME DP - Unbound Medicine ER -