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Autonomic dysfunction in Parkinson's disease.
Neurol Sci. 2003 May; 24 Suppl 1:S32-4.NS

Abstract

Autonomic dysfunction in patients with Parkinson's disease (PD) has been recognized since the original description by James Parkinson in 1817. Autonomic failure can be the clinical presentation of other diseases like pure autonomic failure (PAF) and multiple system atrophy (MSA). Both the central and peripheral autonomic nervous systems can be affected in PD. Rajput and Rozdilsky described cell loss and Lewy bodies within the sympathetic ganglia and antibodies to sympathetic neurons have been detected in PD patients. Lewy bodies can be seen in autonomic regulatory regions, including the hypothalamus, sympathetic (intermediolateral nucleus of the thoracic cord and sympathetic ganglia), and parasympathetic system (dorsal, vagal, and sacral parasympathetic nuclei). Lewy bodies were also found in the adrenal medulla and in the neural plexi innervating the gut, heart and pelvis. Symptoms of dysautonomia are variable, and include cardiovascular symptoms, gastrointestinal, urogenital, sudomotor and thermoregulatory dysfunction, pupillary abnormalities and sleep and respiratory disorders. They may represent a useful tool in the differential diagnosis of "atypical" or "complicated" parkinsonisms.

Authors+Show Affiliations

Laboratory of Autonomic Physiopathology and Cerebrovascular Diagnostics, Department of Cerebrovascular Diseases IRCCS C. Mondino Foundation, Pavia, Italy.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12774210

Citation

Micieli, G, et al. "Autonomic Dysfunction in Parkinson's Disease." Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, vol. 24 Suppl 1, 2003, pp. S32-4.
Micieli G, Tosi P, Marcheselli S, et al. Autonomic dysfunction in Parkinson's disease. Neurol Sci. 2003;24 Suppl 1:S32-4.
Micieli, G., Tosi, P., Marcheselli, S., & Cavallini, A. (2003). Autonomic dysfunction in Parkinson's disease. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 24 Suppl 1, S32-4.
Micieli G, et al. Autonomic Dysfunction in Parkinson's Disease. Neurol Sci. 2003;24 Suppl 1:S32-4. PubMed PMID: 12774210.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autonomic dysfunction in Parkinson's disease. AU - Micieli,G, AU - Tosi,P, AU - Marcheselli,S, AU - Cavallini,A, PY - 2003/5/30/pubmed PY - 2003/8/6/medline PY - 2003/5/30/entrez SP - S32 EP - 4 JF - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology JO - Neurol Sci VL - 24 Suppl 1 N2 - Autonomic dysfunction in patients with Parkinson's disease (PD) has been recognized since the original description by James Parkinson in 1817. Autonomic failure can be the clinical presentation of other diseases like pure autonomic failure (PAF) and multiple system atrophy (MSA). Both the central and peripheral autonomic nervous systems can be affected in PD. Rajput and Rozdilsky described cell loss and Lewy bodies within the sympathetic ganglia and antibodies to sympathetic neurons have been detected in PD patients. Lewy bodies can be seen in autonomic regulatory regions, including the hypothalamus, sympathetic (intermediolateral nucleus of the thoracic cord and sympathetic ganglia), and parasympathetic system (dorsal, vagal, and sacral parasympathetic nuclei). Lewy bodies were also found in the adrenal medulla and in the neural plexi innervating the gut, heart and pelvis. Symptoms of dysautonomia are variable, and include cardiovascular symptoms, gastrointestinal, urogenital, sudomotor and thermoregulatory dysfunction, pupillary abnormalities and sleep and respiratory disorders. They may represent a useful tool in the differential diagnosis of "atypical" or "complicated" parkinsonisms. SN - 1590-1874 UR - https://www.unboundmedicine.com/medline/citation/12774210/Autonomic_dysfunction_in_Parkinson's_disease_ L2 - https://link.springer.com/10.1007/s100720300035 DB - PRIME DP - Unbound Medicine ER -