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[Tibolone therapy in postmenopausal women with a history of many risk factors].

Abstract

INTRODUCTION

The changes of the indications and the use of hormone replacement therapy have entered into the focus of interest.

AIMS

The author studied whether hormone replacement therapy can be used in postmenopausal patients with high risk factors in their history (thromboembolic disorders, diabetes mellitus, hypertension, stroke, cardiovascular disease, pulmonary embolism).

METHODS

Tibolone 2.5 mg daily was prescribed. Data of 124 patients with the above conditions were analized at the beginning and at 12, 24, 36 months follow-up visits. The frequency of exacerbation of the anamnestic risk factors, menopausal complaints, laboratory tests and instrumental tests (transvaginal sonography, mammography, bone densitometry), as well as efficacy and side effects of the therapy were studied.

RESULTS

During the 36-months follow up tibolone therapy effectively reduced menopausal complaints, caused no increase in the anamnestic risk factors, or serious side effects and did not worsened the results of the laboratory tests.

CONCLUSION

In the author's opinion hormone replacement therapy with tibolone can be safely performed in patients with high risk factors in the history.

Authors+Show Affiliations

Szeged Városi Rendelóintézet, Klimax Ambulancia.

Source

Orvosi hetilap 144:15 2003 Apr 13 pg 701-4

MeSH

Cardiovascular Diseases
Diabetes Complications
Estrogen Receptor Modulators
Estrogen Replacement Therapy
Female
Humans
Hypertension
Middle Aged
Norpregnenes
Postmenopause
Risk Factors
Stroke
Thromboembolism

Pub Type(s)

English Abstract
Journal Article

Language

hun

PubMed ID

12774429

Citation

TY - JOUR T1 - [Tibolone therapy in postmenopausal women with a history of many risk factors]. A1 - Szántó,Ferenc, PY - 2003/5/31/pubmed PY - 2003/7/4/medline PY - 2003/5/31/entrez SP - 701 EP - 4 JF - Orvosi hetilap JO - Orv Hetil VL - 144 IS - 15 N2 - INTRODUCTION: The changes of the indications and the use of hormone replacement therapy have entered into the focus of interest. AIMS: The author studied whether hormone replacement therapy can be used in postmenopausal patients with high risk factors in their history (thromboembolic disorders, diabetes mellitus, hypertension, stroke, cardiovascular disease, pulmonary embolism). METHODS: Tibolone 2.5 mg daily was prescribed. Data of 124 patients with the above conditions were analized at the beginning and at 12, 24, 36 months follow-up visits. The frequency of exacerbation of the anamnestic risk factors, menopausal complaints, laboratory tests and instrumental tests (transvaginal sonography, mammography, bone densitometry), as well as efficacy and side effects of the therapy were studied. RESULTS: During the 36-months follow up tibolone therapy effectively reduced menopausal complaints, caused no increase in the anamnestic risk factors, or serious side effects and did not worsened the results of the laboratory tests. CONCLUSION: In the author's opinion hormone replacement therapy with tibolone can be safely performed in patients with high risk factors in the history. SN - 0030-6002 UR - https://www.unboundmedicine.com/medline/citation/12774429/full_citation/[Tibolone_therapy_in_postmenopausal_women_with_a_history_of_many_risk_factors] L2 - http://www.nlm.nih.gov/medlineplus/diabetescomplications.html ER -