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[Tibolone therapy in postmenopausal women with a history of many risk factors].
INTRODUCTIONThe changes of the indications and the use of hormone replacement therapy have entered into the focus of interest.
AIMSThe author studied whether hormone replacement therapy can be used in postmenopausal patients with high risk factors in their history (thromboembolic disorders, diabetes mellitus, hypertension, stroke, cardiovascular disease, pulmonary embolism).
METHODSTibolone 2.5 mg daily was prescribed. Data of 124 patients with the above conditions were analized at the beginning and at 12, 24, 36 months follow-up visits. The frequency of exacerbation of the anamnestic risk factors, menopausal complaints, laboratory tests and instrumental tests (transvaginal sonography, mammography, bone densitometry), as well as efficacy and side effects of the therapy were studied.
RESULTSDuring the 36-months follow up tibolone therapy effectively reduced menopausal complaints, caused no increase in the anamnestic risk factors, or serious side effects and did not worsened the results of the laboratory tests.
CONCLUSIONIn the author's opinion hormone replacement therapy with tibolone can be safely performed in patients with high risk factors in the history.
Szeged Városi Rendelóintézet, Klimax Ambulancia.
Orvosi hetilap 144:15 2003 Apr 13 pg 701-4
Estrogen Receptor Modulators
Estrogen Replacement Therapy
Pub Type(s)English Abstract