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Safe treatment of head/neck AD with tacrolimus ointment.
J Dermatolog Treat. 2003 Jun; 14(2):86-94.JD

Abstract

BACKGROUND

Atopic dermatitis(AD) with head and neck involvement is common and therapeutically challenging.

METHODS

Efficacy and safety data specific to treatment of head/neck regions with tacrolimus ointment (Protopic) from three double-blind, randomized, vehicle-controlled studies are reported. A total of 631 adult and 352 pediatric patients with moderate to severe atopic dermatitis applied the vehicle, 0.03% or 0.1% tacrolimus ointment twice daily to affected areas for up to 12 weeks.

RESULTS

Significant improvements from baseline to end of treatment for signs of atopic dermatitis (erythema, edema, excoriation, oozing, scaling, and lichenification) were noted for head/neck and non-head/neck areas treated with either 0.03% or 0.1% tacrolimus ointment (p<0.001). Within each treatment group, the overall 12-week adjusted incidence rate of application site adverse events was similar for both head/neck and non-head/neck areas. The incidence of common adverse events such as pruritus, "skin burning", erythema, infection, and skin tingling in head/neck areas was comparable to that observed in non-head/neck areas within each treatment group. The overall prevalence of application site adverse events decreased rapidly during the first few days of treatment.

CONCLUSION

Tacrolimus ointment is a safe and effective treatment for atopic dermatitis on the head and neck.

Authors+Show Affiliations

Department of Dermatology, University of Michigan Medical Center, 1618 Taubman Center, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-0314, USA. swkang@med.umich.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12775315

Citation

Kang, S, et al. "Safe Treatment of Head/neck AD With Tacrolimus Ointment." The Journal of Dermatological Treatment, vol. 14, no. 2, 2003, pp. 86-94.
Kang S, Paller A, Soter N, et al. Safe treatment of head/neck AD with tacrolimus ointment. J Dermatolog Treat. 2003;14(2):86-94.
Kang, S., Paller, A., Soter, N., Satoi, Y., Rico, M. J., & Hanifin, J. M. (2003). Safe treatment of head/neck AD with tacrolimus ointment. The Journal of Dermatological Treatment, 14(2), 86-94.
Kang S, et al. Safe Treatment of Head/neck AD With Tacrolimus Ointment. J Dermatolog Treat. 2003;14(2):86-94. PubMed PMID: 12775315.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Safe treatment of head/neck AD with tacrolimus ointment. AU - Kang,S, AU - Paller,A, AU - Soter,N, AU - Satoi,Y, AU - Rico,M J, AU - Hanifin,J M, PY - 2003/5/31/pubmed PY - 2003/7/11/medline PY - 2003/5/31/entrez SP - 86 EP - 94 JF - The Journal of dermatological treatment JO - J Dermatolog Treat VL - 14 IS - 2 N2 - BACKGROUND: Atopic dermatitis(AD) with head and neck involvement is common and therapeutically challenging. METHODS: Efficacy and safety data specific to treatment of head/neck regions with tacrolimus ointment (Protopic) from three double-blind, randomized, vehicle-controlled studies are reported. A total of 631 adult and 352 pediatric patients with moderate to severe atopic dermatitis applied the vehicle, 0.03% or 0.1% tacrolimus ointment twice daily to affected areas for up to 12 weeks. RESULTS: Significant improvements from baseline to end of treatment for signs of atopic dermatitis (erythema, edema, excoriation, oozing, scaling, and lichenification) were noted for head/neck and non-head/neck areas treated with either 0.03% or 0.1% tacrolimus ointment (p<0.001). Within each treatment group, the overall 12-week adjusted incidence rate of application site adverse events was similar for both head/neck and non-head/neck areas. The incidence of common adverse events such as pruritus, "skin burning", erythema, infection, and skin tingling in head/neck areas was comparable to that observed in non-head/neck areas within each treatment group. The overall prevalence of application site adverse events decreased rapidly during the first few days of treatment. CONCLUSION: Tacrolimus ointment is a safe and effective treatment for atopic dermatitis on the head and neck. SN - 0954-6634 UR - https://www.unboundmedicine.com/medline/citation/12775315/Safe_treatment_of_head/neck_AD_with_tacrolimus_ointment_ L2 - http://www.tandfonline.com/doi/full/10.1080/09546630310004324 DB - PRIME DP - Unbound Medicine ER -