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C-reactive protein, interleukin-6, and fibrinogen as predictors of coronary heart disease: the PRIME Study.
Arterioscler Thromb Vasc Biol 2003; 23(7):1255-61AT

Abstract

OBJECTIVE

This study was undertaken to examine the association of plasma inflammatory markers such as C-reactive protein (CRP), interleukin-6, and fibrinogen with the incidence of coronary heart disease within the prospective cohort study on myocardial infarction (PRIME study).

METHODS AND RESULTS

Multiple risk factors were recorded at baseline in 9758 men aged 50 to 59 years who were free of coronary heart disease (CHD) on entry. Nested case-control comparisons were carried out on 317 participants who suffered myocardial infarction (MI)-coronary death (n=163) or angina (n=158) as an initial CHD event during a follow-up for 5 years. After adjustment for traditional risk factors, incident MI-coronary death, but not angina, was significantly associated with CRP, interleukin-6, and fibrinogen, but only interleukin-6 remained significantly associated with MI-coronary death when the 3 inflammatory markers were included in the model. The different interleukin-6 levels in Northern Ireland and France partly explained the difference in risk between these countries. Interleukin-6 appeared as a risk marker of MI-coronary death, and it improved the definition of CHD risk beyond LDL cholesterol.

CONCLUSIONS

This association may reflect the underlying inflammatory reaction located in the atherosclerotic plaque or a genetic susceptibility on the part of CHD subjects to answer a proinflammatory stimulus and subsequent increase in hepatic CRP gene expression.

Authors+Show Affiliations

Department of Atherosclerosis, SERLIA-INSERM UR545, Institut Pasteur de Lille and University Lille II, 1 Rue du Professeur Calmette, 59019 Lille Cedex, France. Gerald.Luc@pasteur-lille.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12775578

Citation

Luc, Gérald, et al. "C-reactive Protein, Interleukin-6, and Fibrinogen as Predictors of Coronary Heart Disease: the PRIME Study." Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 23, no. 7, 2003, pp. 1255-61.
Luc G, Bard JM, Juhan-Vague I, et al. C-reactive protein, interleukin-6, and fibrinogen as predictors of coronary heart disease: the PRIME Study. Arterioscler Thromb Vasc Biol. 2003;23(7):1255-61.
Luc, G., Bard, J. M., Juhan-Vague, I., Ferrieres, J., Evans, A., Amouyel, P., ... Ducimetiere, P. (2003). C-reactive protein, interleukin-6, and fibrinogen as predictors of coronary heart disease: the PRIME Study. Arteriosclerosis, Thrombosis, and Vascular Biology, 23(7), pp. 1255-61.
Luc G, et al. C-reactive Protein, Interleukin-6, and Fibrinogen as Predictors of Coronary Heart Disease: the PRIME Study. Arterioscler Thromb Vasc Biol. 2003 Jul 1;23(7):1255-61. PubMed PMID: 12775578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - C-reactive protein, interleukin-6, and fibrinogen as predictors of coronary heart disease: the PRIME Study. AU - Luc,Gérald, AU - Bard,Jean-Marie, AU - Juhan-Vague,Irène, AU - Ferrieres,Jean, AU - Evans,Alun, AU - Amouyel,Philippe, AU - Arveiler,Dominique, AU - Fruchart,Jean-Charles, AU - Ducimetiere,Pierre, AU - ,, Y1 - 2003/05/29/ PY - 2003/5/31/pubmed PY - 2004/2/6/medline PY - 2003/5/31/entrez SP - 1255 EP - 61 JF - Arteriosclerosis, thrombosis, and vascular biology JO - Arterioscler. Thromb. Vasc. Biol. VL - 23 IS - 7 N2 - OBJECTIVE: This study was undertaken to examine the association of plasma inflammatory markers such as C-reactive protein (CRP), interleukin-6, and fibrinogen with the incidence of coronary heart disease within the prospective cohort study on myocardial infarction (PRIME study). METHODS AND RESULTS: Multiple risk factors were recorded at baseline in 9758 men aged 50 to 59 years who were free of coronary heart disease (CHD) on entry. Nested case-control comparisons were carried out on 317 participants who suffered myocardial infarction (MI)-coronary death (n=163) or angina (n=158) as an initial CHD event during a follow-up for 5 years. After adjustment for traditional risk factors, incident MI-coronary death, but not angina, was significantly associated with CRP, interleukin-6, and fibrinogen, but only interleukin-6 remained significantly associated with MI-coronary death when the 3 inflammatory markers were included in the model. The different interleukin-6 levels in Northern Ireland and France partly explained the difference in risk between these countries. Interleukin-6 appeared as a risk marker of MI-coronary death, and it improved the definition of CHD risk beyond LDL cholesterol. CONCLUSIONS: This association may reflect the underlying inflammatory reaction located in the atherosclerotic plaque or a genetic susceptibility on the part of CHD subjects to answer a proinflammatory stimulus and subsequent increase in hepatic CRP gene expression. SN - 1524-4636 UR - https://www.unboundmedicine.com/medline/citation/12775578/C_reactive_protein_interleukin_6_and_fibrinogen_as_predictors_of_coronary_heart_disease:_the_PRIME_Study_ L2 - http://www.ahajournals.org/doi/full/10.1161/01.ATV.0000079512.66448.1D?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -