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[Study of protective effect of leech, radix Salviae miltiorrhizae and its composite recipe on vascular endothelial cells in rats with blood stasis syndrome].
Zhongguo Zhong Yao Za Zhi. 2001 Oct; 26(10):703-6.ZZ

Abstract

OBJECTIVE

To study the protective effect for Chinese medicine of promoting blood circulation and removing blood stasis (PBCRBS) on vascular endothelial cells (VEC) in rats, aiming at further research on the mechanism of blood stasis syndrome and PBCRBS.

METHOD

Establishing a model of blood stasis with endothelial damage by means of giving rats an injection of adrenalin and making it swim in ice-cold water, then measuring the number of circulating endothelial cells (CEC) in whole blood and rheology. Moreover observing the change of the above indexes after the rats have taken Leech, Radix salviae miltrorrhizae (RSM) and its composite recipe for 5 days or 10 days.

RESULT

It could increase the number of CEC accompanied by whole blood viscosity, fibrinogen and hematocrit in rats with blood stasis. But for groups taking Chinese medicine, the number of CEC was decreased distinctively and blood rheology was improved.

CONCLUSION

The rat with blood stasis syndrome suffered from obvious injury of VEC. The Leech, RSM and its composite recipe could protect VEC.

Authors+Show Affiliations

Institute of Basic Theory, China Academy of Traditinal Chinese Medicine, Beijing 100700, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

12776322

Citation

Li, F W., et al. "[Study of Protective Effect of Leech, Radix Salviae Miltiorrhizae and Its Composite Recipe On Vascular Endothelial Cells in Rats With Blood Stasis Syndrome]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 26, no. 10, 2001, pp. 703-6.
Li FW, Zhang LS, Liu H, et al. [Study of protective effect of leech, radix Salviae miltiorrhizae and its composite recipe on vascular endothelial cells in rats with blood stasis syndrome]. Zhongguo Zhong Yao Za Zhi. 2001;26(10):703-6.
Li, F. W., Zhang, L. S., Liu, H., Cai, Y. C., Pan, J. H., Jia, X. Y., & Ding, J. X. (2001). [Study of protective effect of leech, radix Salviae miltiorrhizae and its composite recipe on vascular endothelial cells in rats with blood stasis syndrome]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 26(10), 703-6.
Li FW, et al. [Study of Protective Effect of Leech, Radix Salviae Miltiorrhizae and Its Composite Recipe On Vascular Endothelial Cells in Rats With Blood Stasis Syndrome]. Zhongguo Zhong Yao Za Zhi. 2001;26(10):703-6. PubMed PMID: 12776322.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Study of protective effect of leech, radix Salviae miltiorrhizae and its composite recipe on vascular endothelial cells in rats with blood stasis syndrome]. AU - Li,F W, AU - Zhang,L S, AU - Liu,H, AU - Cai,Y C, AU - Pan,J H, AU - Jia,X Y, AU - Ding,J X, PY - 2003/6/5/pubmed PY - 2003/10/22/medline PY - 2003/6/5/entrez SP - 703 EP - 6 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 26 IS - 10 N2 - OBJECTIVE: To study the protective effect for Chinese medicine of promoting blood circulation and removing blood stasis (PBCRBS) on vascular endothelial cells (VEC) in rats, aiming at further research on the mechanism of blood stasis syndrome and PBCRBS. METHOD: Establishing a model of blood stasis with endothelial damage by means of giving rats an injection of adrenalin and making it swim in ice-cold water, then measuring the number of circulating endothelial cells (CEC) in whole blood and rheology. Moreover observing the change of the above indexes after the rats have taken Leech, Radix salviae miltrorrhizae (RSM) and its composite recipe for 5 days or 10 days. RESULT: It could increase the number of CEC accompanied by whole blood viscosity, fibrinogen and hematocrit in rats with blood stasis. But for groups taking Chinese medicine, the number of CEC was decreased distinctively and blood rheology was improved. CONCLUSION: The rat with blood stasis syndrome suffered from obvious injury of VEC. The Leech, RSM and its composite recipe could protect VEC. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/12776322/[Study_of_protective_effect_of_leech_radix_Salviae_miltiorrhizae_and_its_composite_recipe_on_vascular_endothelial_cells_in_rats_with_blood_stasis_syndrome]_ DB - PRIME DP - Unbound Medicine ER -