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[Effects of aqueous extract in herba of Lysimachia christinae on hyperuricemia in mice].
Zhongguo Zhong Yao Za Zhi. 2002 Dec; 27(12):939-41, 944.ZZ

Abstract

OBJECTIVE

To study hypouricemic effect of aqueous extract of Lysimachia christinae on hyperuricemia in mice.

METHOD

The uricase inhibitor potassium oxonate was used to induce hyperuricemia in mice, and serum uric acid level was determined with the phosphotungstic acid method.

RESULT

The aqueous extract of Lysimachia christinae, when administered orally to the oxonate-induced hyperuricemic mice at the doses of 5.2, 10.4 and 20.8 g.kg-1, was able to elicit dose-dependent hypouricemic effects. At these doses of the extract, the serum urate levels of the oxonate-pretreated mice showed no difference from the normal mice. In normal mice, however, oral administration of the extract at the same doses did not produce any observable hypouricemic effects.

CONCLUSION

The aqueous extract of Lysimachia christinae possesses potent hypuricemic effects on models of hyperuricemia in mice pretreated with oxonate.

Authors+Show Affiliations

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, Jiangsu, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

12776538

Citation

Wang, Hai-dong, et al. "[Effects of Aqueous Extract in Herba of Lysimachia Christinae On Hyperuricemia in Mice]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 27, no. 12, 2002, pp. 939-41, 944.
Wang HD, Ge F, Guo YS, et al. [Effects of aqueous extract in herba of Lysimachia christinae on hyperuricemia in mice]. Zhongguo Zhong Yao Za Zhi. 2002;27(12):939-41, 944.
Wang, H. D., Ge, F., Guo, Y. S., & Kong, L. D. (2002). [Effects of aqueous extract in herba of Lysimachia christinae on hyperuricemia in mice]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 27(12), 939-41, 944.
Wang HD, et al. [Effects of Aqueous Extract in Herba of Lysimachia Christinae On Hyperuricemia in Mice]. Zhongguo Zhong Yao Za Zhi. 2002;27(12):939-41, 944. PubMed PMID: 12776538.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of aqueous extract in herba of Lysimachia christinae on hyperuricemia in mice]. AU - Wang,Hai-dong, AU - Ge,Fei, AU - Guo,Yu-song, AU - Kong,Ling-dong, PY - 2003/6/5/pubmed PY - 2003/10/24/medline PY - 2003/6/5/entrez SP - 939-41, 944 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 27 IS - 12 N2 - OBJECTIVE: To study hypouricemic effect of aqueous extract of Lysimachia christinae on hyperuricemia in mice. METHOD: The uricase inhibitor potassium oxonate was used to induce hyperuricemia in mice, and serum uric acid level was determined with the phosphotungstic acid method. RESULT: The aqueous extract of Lysimachia christinae, when administered orally to the oxonate-induced hyperuricemic mice at the doses of 5.2, 10.4 and 20.8 g.kg-1, was able to elicit dose-dependent hypouricemic effects. At these doses of the extract, the serum urate levels of the oxonate-pretreated mice showed no difference from the normal mice. In normal mice, however, oral administration of the extract at the same doses did not produce any observable hypouricemic effects. CONCLUSION: The aqueous extract of Lysimachia christinae possesses potent hypuricemic effects on models of hyperuricemia in mice pretreated with oxonate. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/12776538/[Effects_of_aqueous_extract_in_herba_of_Lysimachia_christinae_on_hyperuricemia_in_mice]_ DB - PRIME DP - Unbound Medicine ER -
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