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Dietary intakes of fat and risk of Parkinson's disease.

Abstract

Previous epidemiologic studies have generated inconsistent results regarding the associations between fat intakes and risk of Parkinson's disease. The authors investigated these associations in two large, prospective US cohorts. They documented 191 incident cases of Parkinson's disease in men (1986-1998) and 168 in women (1980-1998) during the follow-up. Overall, intakes of total fat or major types of fat were not significantly associated with the risk. The relative risks comparing the highest quintile of animal fat intake with the lowest were 1.42 for men (95% confidence interval (CI): 0.91, 2.20; p for trend = 0.1) and 0.65 for women (95% CI: 0.36, 1.16; p for trend = 0.3). For men, but not women, replacement of polyunsaturated fat with saturated fat was associated with a significantly increased risk (5% of energy intake, relative risk (RR) = 1.83, 95% CI: 1.10, 3.03). Of the individual polyunsaturated fatty acids, arachidonic acid tended to be inversely associated with the risk (pooled RR between extreme quintiles = 0.65, 95% CI: 0.46, 0.91; p for trend = 0.05). Results do not support an important role of overall fat intake in the pathogenesis of Parkinson's disease, but a possible adverse effect of saturated fat for men could not be excluded.

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  • Authors+Show Affiliations

    ,

    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA. hchen@hsph.harvard.edu

    , , ,

    Source

    American journal of epidemiology 157:11 2003 Jun 01 pg 1007-14

    MeSH

    Adult
    Aged
    Cohort Studies
    Dietary Fats
    Dietary Fats, Unsaturated
    Female
    Follow-Up Studies
    Humans
    Longitudinal Studies
    Male
    Middle Aged
    Parkinson Disease
    Prospective Studies
    Risk
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    12777364

    Citation

    Chen, Honglei, et al. "Dietary Intakes of Fat and Risk of Parkinson's Disease." American Journal of Epidemiology, vol. 157, no. 11, 2003, pp. 1007-14.
    Chen H, Zhang SM, Hernán MA, et al. Dietary intakes of fat and risk of Parkinson's disease. Am J Epidemiol. 2003;157(11):1007-14.
    Chen, H., Zhang, S. M., Hernán, M. A., Willett, W. C., & Ascherio, A. (2003). Dietary intakes of fat and risk of Parkinson's disease. American Journal of Epidemiology, 157(11), pp. 1007-14.
    Chen H, et al. Dietary Intakes of Fat and Risk of Parkinson's Disease. Am J Epidemiol. 2003 Jun 1;157(11):1007-14. PubMed PMID: 12777364.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary intakes of fat and risk of Parkinson's disease. AU - Chen,Honglei, AU - Zhang,Shumin M, AU - Hernán,Miguel A, AU - Willett,Walter C, AU - Ascherio,Alberto, PY - 2003/6/5/pubmed PY - 2003/6/27/medline PY - 2003/6/5/entrez SP - 1007 EP - 14 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 157 IS - 11 N2 - Previous epidemiologic studies have generated inconsistent results regarding the associations between fat intakes and risk of Parkinson's disease. The authors investigated these associations in two large, prospective US cohorts. They documented 191 incident cases of Parkinson's disease in men (1986-1998) and 168 in women (1980-1998) during the follow-up. Overall, intakes of total fat or major types of fat were not significantly associated with the risk. The relative risks comparing the highest quintile of animal fat intake with the lowest were 1.42 for men (95% confidence interval (CI): 0.91, 2.20; p for trend = 0.1) and 0.65 for women (95% CI: 0.36, 1.16; p for trend = 0.3). For men, but not women, replacement of polyunsaturated fat with saturated fat was associated with a significantly increased risk (5% of energy intake, relative risk (RR) = 1.83, 95% CI: 1.10, 3.03). Of the individual polyunsaturated fatty acids, arachidonic acid tended to be inversely associated with the risk (pooled RR between extreme quintiles = 0.65, 95% CI: 0.46, 0.91; p for trend = 0.05). Results do not support an important role of overall fat intake in the pathogenesis of Parkinson's disease, but a possible adverse effect of saturated fat for men could not be excluded. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/12777364/Dietary_intakes_of_fat_and_risk_of_Parkinson's_disease_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwg073 DB - PRIME DP - Unbound Medicine ER -