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Effects of chronic AICAR treatment on fiber composition, enzyme activity, UCP3, and PGC-1 in rat muscles.
J Appl Physiol (1985). 2003 Sep; 95(3):960-8.JA

Abstract

This study was designed to determine the histological and metabolic effects of the administration of 5'-AMP-activated protein kinase (AMPK) activator 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR) for 14 successive days. AICAR treatment caused a significant decrease in the percentage of type IIB fibers and the concomitant increase in the percentage of type IIX fibers in extensor digitorum longus (EDL) muscle. The capillary density and the capillary-to-fiber ratio were not altered by AICAR. AICAR treatment increased the glycolytic and oxidative enzyme activities but not the antioxidant enzyme activities. The AICAR treatment increased the uncoupling protein 3 (UCP3) level in EDL and the peroxisome proliferator-activated receptor-gamma coactivator-1alpha protein level in the soleus and EDL muscles, whereas the myogenin level was not altered by AICAR. These results seem to imply that the chronic activation of AMPK alters such muscle histochemical and metabolic characteristics.

Authors+Show Affiliations

Institute of Health Science, Kyushu University, Kasuga, Fukuoka 816-8580, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12777406

Citation

Suwa, Masataka, et al. "Effects of Chronic AICAR Treatment On Fiber Composition, Enzyme Activity, UCP3, and PGC-1 in Rat Muscles." Journal of Applied Physiology (Bethesda, Md. : 1985), vol. 95, no. 3, 2003, pp. 960-8.
Suwa M, Nakano H, Kumagai S. Effects of chronic AICAR treatment on fiber composition, enzyme activity, UCP3, and PGC-1 in rat muscles. J Appl Physiol. 2003;95(3):960-8.
Suwa, M., Nakano, H., & Kumagai, S. (2003). Effects of chronic AICAR treatment on fiber composition, enzyme activity, UCP3, and PGC-1 in rat muscles. Journal of Applied Physiology (Bethesda, Md. : 1985), 95(3), 960-8.
Suwa M, Nakano H, Kumagai S. Effects of Chronic AICAR Treatment On Fiber Composition, Enzyme Activity, UCP3, and PGC-1 in Rat Muscles. J Appl Physiol. 2003;95(3):960-8. PubMed PMID: 12777406.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of chronic AICAR treatment on fiber composition, enzyme activity, UCP3, and PGC-1 in rat muscles. AU - Suwa,Masataka, AU - Nakano,Hiroshi, AU - Kumagai,Shuzo, Y1 - 2003/05/30/ PY - 2003/6/5/pubmed PY - 2004/4/9/medline PY - 2003/6/5/entrez SP - 960 EP - 8 JF - Journal of applied physiology (Bethesda, Md. : 1985) JO - J. Appl. Physiol. VL - 95 IS - 3 N2 - This study was designed to determine the histological and metabolic effects of the administration of 5'-AMP-activated protein kinase (AMPK) activator 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR) for 14 successive days. AICAR treatment caused a significant decrease in the percentage of type IIB fibers and the concomitant increase in the percentage of type IIX fibers in extensor digitorum longus (EDL) muscle. The capillary density and the capillary-to-fiber ratio were not altered by AICAR. AICAR treatment increased the glycolytic and oxidative enzyme activities but not the antioxidant enzyme activities. The AICAR treatment increased the uncoupling protein 3 (UCP3) level in EDL and the peroxisome proliferator-activated receptor-gamma coactivator-1alpha protein level in the soleus and EDL muscles, whereas the myogenin level was not altered by AICAR. These results seem to imply that the chronic activation of AMPK alters such muscle histochemical and metabolic characteristics. SN - 8750-7587 UR - https://www.unboundmedicine.com/medline/citation/12777406/Effects_of_chronic_AICAR_treatment_on_fiber_composition_enzyme_activity_UCP3_and_PGC_1_in_rat_muscles_ L2 - http://journals.physiology.org/doi/full/10.1152/japplphysiol.00349.2003?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -