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Effect of parathyroidectomy on bone mineral density in hemodialysis patients with secondary hyperparathyroidism: possible usefulness of preoperative determination of parathyroid hormone level for prediction of bone regain.
Horm Metab Res. 2003 Apr; 35(4):259-64.HM

Abstract

PURPOSE

To examine longitudinal changes of bone mineral density (BMD) after parathyroidectomy (PTx) in patients undergoing maintenance hemodialysis (HD) with severe secondary hyperparathyroidism (HPT) to determine which factor contributes most to bone changes.

METHODS

Fifteen Japanese HD patients who had been refractory to medical therapy were subject to PTx with autotransplantation. We measured BMD by dual energy X-ray absorptiometry (DXA) at the lumbar spine (L2 - 4 BMD) and the distal 1/3 region of the radius (1/3R BMD) at 1, 3, 6, 12, 24, and 36 months after PTx.

RESULTS

Baseline Z-score of BMD was markedly low at 1/3R (- 3.07) and slightly low at L2 - 4 (-0.59) in this group. A significant increase in L2 - 4 BMD was observed as early as one month after PTx, which was sustained afterwards. Annual percent changes in L2 - 4 and 1/3R BMD were + 15.6 % and + 6.4 %, respectively. The annual percent changes in BMD at both sites were positively associated with preoperative intact PTH levels (L2 - 4; r = 0.642, p = 0.010, 1/3R; r = 0.884, p < 0.001) and total alkaline phosphatase (ALP) levels (L2 - 4; r = 0.663, p = 0.007, 1/3R; r = 0.858, p < 0.001). Stepwise multiple regression analysis revealed that serum levels of intact PTH and ALP were the best predictors of both percentage and net changes in radial BMD with high determination coefficients (r 2 > 0.8).

CONCLUSION

Successful PTx following appropriate supplementation with vitamin D and calcium provides a marked increase in lumbar BMD and a modest increase in radial BMD in HD patients with secondary HPT. Preoperative levels of PTH and ALP are useful for predicting postoperative changes in bone mass.

Authors+Show Affiliations

Division of Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan. syano@rics.bwh.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12778370

Citation

Yano, S, et al. "Effect of Parathyroidectomy On Bone Mineral Density in Hemodialysis Patients With Secondary Hyperparathyroidism: Possible Usefulness of Preoperative Determination of Parathyroid Hormone Level for Prediction of Bone Regain." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 35, no. 4, 2003, pp. 259-64.
Yano S, Sugimoto T, Tsukamoto T, et al. Effect of parathyroidectomy on bone mineral density in hemodialysis patients with secondary hyperparathyroidism: possible usefulness of preoperative determination of parathyroid hormone level for prediction of bone regain. Horm Metab Res. 2003;35(4):259-64.
Yano, S., Sugimoto, T., Tsukamoto, T., Yamaguchi, T., Hattori, T., Sekita, K. I., Kaji, H., Hattori, S., Kobayashi, A., & Chihara, K. (2003). Effect of parathyroidectomy on bone mineral density in hemodialysis patients with secondary hyperparathyroidism: possible usefulness of preoperative determination of parathyroid hormone level for prediction of bone regain. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 35(4), 259-64.
Yano S, et al. Effect of Parathyroidectomy On Bone Mineral Density in Hemodialysis Patients With Secondary Hyperparathyroidism: Possible Usefulness of Preoperative Determination of Parathyroid Hormone Level for Prediction of Bone Regain. Horm Metab Res. 2003;35(4):259-64. PubMed PMID: 12778370.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of parathyroidectomy on bone mineral density in hemodialysis patients with secondary hyperparathyroidism: possible usefulness of preoperative determination of parathyroid hormone level for prediction of bone regain. AU - Yano,S, AU - Sugimoto,T, AU - Tsukamoto,T, AU - Yamaguchi,T, AU - Hattori,T, AU - Sekita,K-I, AU - Kaji,H, AU - Hattori,S, AU - Kobayashi,A, AU - Chihara,K, PY - 2003/6/5/pubmed PY - 2004/1/9/medline PY - 2003/6/5/entrez SP - 259 EP - 64 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm Metab Res VL - 35 IS - 4 N2 - PURPOSE: To examine longitudinal changes of bone mineral density (BMD) after parathyroidectomy (PTx) in patients undergoing maintenance hemodialysis (HD) with severe secondary hyperparathyroidism (HPT) to determine which factor contributes most to bone changes. METHODS: Fifteen Japanese HD patients who had been refractory to medical therapy were subject to PTx with autotransplantation. We measured BMD by dual energy X-ray absorptiometry (DXA) at the lumbar spine (L2 - 4 BMD) and the distal 1/3 region of the radius (1/3R BMD) at 1, 3, 6, 12, 24, and 36 months after PTx. RESULTS: Baseline Z-score of BMD was markedly low at 1/3R (- 3.07) and slightly low at L2 - 4 (-0.59) in this group. A significant increase in L2 - 4 BMD was observed as early as one month after PTx, which was sustained afterwards. Annual percent changes in L2 - 4 and 1/3R BMD were + 15.6 % and + 6.4 %, respectively. The annual percent changes in BMD at both sites were positively associated with preoperative intact PTH levels (L2 - 4; r = 0.642, p = 0.010, 1/3R; r = 0.884, p < 0.001) and total alkaline phosphatase (ALP) levels (L2 - 4; r = 0.663, p = 0.007, 1/3R; r = 0.858, p < 0.001). Stepwise multiple regression analysis revealed that serum levels of intact PTH and ALP were the best predictors of both percentage and net changes in radial BMD with high determination coefficients (r 2 > 0.8). CONCLUSION: Successful PTx following appropriate supplementation with vitamin D and calcium provides a marked increase in lumbar BMD and a modest increase in radial BMD in HD patients with secondary HPT. Preoperative levels of PTH and ALP are useful for predicting postoperative changes in bone mass. SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/12778370/Effect_of_parathyroidectomy_on_bone_mineral_density_in_hemodialysis_patients_with_secondary_hyperparathyroidism:_possible_usefulness_of_preoperative_determination_of_parathyroid_hormone_level_for_prediction_of_bone_regain_ L2 - https://www.thieme-connect.com/DOI/DOI?10.1055/s-2003-39483 DB - PRIME DP - Unbound Medicine ER -