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[A study on the relation between the apolipoprotein E promoter -427C/T polymorphism and Alzheimer's disease].

Abstract

OBJECTIVE

To determine the relation between the apolipoprotein E(apoE) promoter -427C/T polymorphism and Alzheimer's disease (AD) in a Chinese Han population in Shanghai.

METHODS

The apoE promoter -427C/T polymorphism in 104 AD cases and 110 healthy subjects was detected using polymerase chain reaction method and restriction fragment length polymorphism genotyping technique. The differences in polymorphic distribution between the two groups were tested, and odds ratio was computed.

RESULTS

No differences in apoE -427C/T genotypic distribution were observed between AD cases and controls (P>0.05). Even after stratification according to apoE epsilon 4 stratum, there was not any polymorphic distribution difference when epsilon 4 carriers or non epsilon 4 carriers were compared with controls (P>0.05). The association between AD and apoE epsilon 4 appeared in the TT group(OR=3.94,95%, CI:22067038, chi-square=21.48, P<0.05), but not in CT or CC group.

CONCLUSION

ApoE -427C/T polymorphism was not a susceptibility factor for AD in this Han population in Shanghai.

Authors+Show Affiliations

Shanghai Mental Health Centre, Shanghai, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

12778455

Citation

Tang, Guo-mei, et al. "[A Study On the Relation Between the Apolipoprotein E Promoter -427C/T Polymorphism and Alzheimer's Disease]." Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics, vol. 20, no. 3, 2003, pp. 244-6.
Tang GM, Zhang MY, Jiang SD, et al. [A study on the relation between the apolipoprotein E promoter -427C/T polymorphism and Alzheimer's disease]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003;20(3):244-6.
Tang, G. M., Zhang, M. Y., Jiang, S. D., Qian, Y. P., & Wang, D. X. (2003). [A study on the relation between the apolipoprotein E promoter -427C/T polymorphism and Alzheimer's disease]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics, 20(3), pp. 244-6.
Tang GM, et al. [A Study On the Relation Between the Apolipoprotein E Promoter -427C/T Polymorphism and Alzheimer's Disease]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003;20(3):244-6. PubMed PMID: 12778455.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [A study on the relation between the apolipoprotein E promoter -427C/T polymorphism and Alzheimer's disease]. AU - Tang,Guo-mei, AU - Zhang,Ming-yuan, AU - Jiang,San-duo, AU - Qian,Yi-ping, AU - Wang,Dong-xiang, PY - 2003/6/5/pubmed PY - 2009/2/26/medline PY - 2003/6/5/entrez SP - 244 EP - 6 JF - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics JO - Zhonghua Yi Xue Yi Chuan Xue Za Zhi VL - 20 IS - 3 N2 - OBJECTIVE: To determine the relation between the apolipoprotein E(apoE) promoter -427C/T polymorphism and Alzheimer's disease (AD) in a Chinese Han population in Shanghai. METHODS: The apoE promoter -427C/T polymorphism in 104 AD cases and 110 healthy subjects was detected using polymerase chain reaction method and restriction fragment length polymorphism genotyping technique. The differences in polymorphic distribution between the two groups were tested, and odds ratio was computed. RESULTS: No differences in apoE -427C/T genotypic distribution were observed between AD cases and controls (P>0.05). Even after stratification according to apoE epsilon 4 stratum, there was not any polymorphic distribution difference when epsilon 4 carriers or non epsilon 4 carriers were compared with controls (P>0.05). The association between AD and apoE epsilon 4 appeared in the TT group(OR=3.94,95%, CI:22067038, chi-square=21.48, P<0.05), but not in CT or CC group. CONCLUSION: ApoE -427C/T polymorphism was not a susceptibility factor for AD in this Han population in Shanghai. SN - 1003-9406 UR - https://www.unboundmedicine.com/medline/citation/12778455/[A_study_on_the_relation_between_the_apolipoprotein_E_promoter__427C/T_polymorphism_and_Alzheimer's_disease]_ L2 - https://medlineplus.gov/alzheimersdisease.html DB - PRIME DP - Unbound Medicine ER -