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Effects of two lipid-lowering, carotenoid-controlled diets on the oxidative modification of low-density lipoproteins in free-living humans.
Clin Sci (Lond). 2003 Sep; 105(3):355-61.CS

Abstract

This study compares the effects of two lipid-lowering diets [a diet enriched in MUFAs (monounsaturated fatty acids) and a HCLF (high-carbohydrate/low-fat) diet] with a controlled carotenoid content on risk factors for coronary heart disease, including in vitro copper-induced LDL (low-density lipoprotein) oxidation and serum lipid levels. A randomized crossover dietary intervention study, with two diets each consumed for 14-16 days, was conducted in 18 women and 13 men aged 20-70 years, recruited via personal contacts and advertisements in newspapers. Both diets (MUFA-enriched diet and HCLF diet) contained the same basic foods and had a controlled carotenoid content, high in lycopene. The in vitro copper-induced oxidation of isolated LDL showed a longer lag phase (mean difference 7.4 min in women and 7.34 min in men) after the MUFA-enriched diet compared with the HCLF diet. Serum total cholesterol, LDL cholesterol and carotenoid levels were similar after the two diets. Serum triacylglycerol levels were significantly lower and those of HDL (high-density lipoprotein) cholesterol were significantly higher at the end of the MUFA-enriched diet compared with the HCLF diet. It is concluded that the significantly longer lag phase for oxidation of LDL, the higher HDL cholesterol level and the lower triacylglycerol level in subjects following a carotenoid-controlled, MUFA-enriched diet may decrease the risk of coronary heart disease.

Authors+Show Affiliations

Ahuja KD
School of Human Life Sciences, University of Tasmania, Launceston, Tasmania 7250, Australia.
Ashton EL
No affiliation info available
Ball MJ
No affiliation info available

MeSH

AdultAgedCarotenoidsCholesterolCholesterol, HDLCoronary DiseaseCross-Over StudiesDietary CarbohydratesDietary FatsFatty Acids, MonounsaturatedFemaleFruitHumansLipidsLipoproteins, LDLLycopeneMaleMiddle AgedOxidation-ReductionRisk FactorsStatistics, NonparametricTriglyceridesVegetables

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12780345

Citation

Ahuja, Kiran D K., et al. "Effects of Two Lipid-lowering, Carotenoid-controlled Diets On the Oxidative Modification of Low-density Lipoproteins in Free-living Humans." Clinical Science (London, England : 1979), vol. 105, no. 3, 2003, pp. 355-61.
Ahuja KD, Ashton EL, Ball MJ. Effects of two lipid-lowering, carotenoid-controlled diets on the oxidative modification of low-density lipoproteins in free-living humans. Clin Sci (Lond). 2003;105(3):355-61.
Ahuja, K. D., Ashton, E. L., & Ball, M. J. (2003). Effects of two lipid-lowering, carotenoid-controlled diets on the oxidative modification of low-density lipoproteins in free-living humans. Clinical Science (London, England : 1979), 105(3), 355-61.
Ahuja KD, Ashton EL, Ball MJ. Effects of Two Lipid-lowering, Carotenoid-controlled Diets On the Oxidative Modification of Low-density Lipoproteins in Free-living Humans. Clin Sci (Lond). 2003;105(3):355-61. PubMed PMID: 12780345.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of two lipid-lowering, carotenoid-controlled diets on the oxidative modification of low-density lipoproteins in free-living humans. AU - Ahuja,Kiran D K, AU - Ashton,Emma L, AU - Ball,Madeleine J, PY - 2003/06/02/accepted PY - 2003/05/07/revised PY - 2003/01/31/received PY - 2003/6/5/pubmed PY - 2003/10/25/medline PY - 2003/6/5/entrez SP - 355 EP - 61 JF - Clinical science (London, England : 1979) JO - Clin Sci (Lond) VL - 105 IS - 3 N2 - This study compares the effects of two lipid-lowering diets [a diet enriched in MUFAs (monounsaturated fatty acids) and a HCLF (high-carbohydrate/low-fat) diet] with a controlled carotenoid content on risk factors for coronary heart disease, including in vitro copper-induced LDL (low-density lipoprotein) oxidation and serum lipid levels. A randomized crossover dietary intervention study, with two diets each consumed for 14-16 days, was conducted in 18 women and 13 men aged 20-70 years, recruited via personal contacts and advertisements in newspapers. Both diets (MUFA-enriched diet and HCLF diet) contained the same basic foods and had a controlled carotenoid content, high in lycopene. The in vitro copper-induced oxidation of isolated LDL showed a longer lag phase (mean difference 7.4 min in women and 7.34 min in men) after the MUFA-enriched diet compared with the HCLF diet. Serum total cholesterol, LDL cholesterol and carotenoid levels were similar after the two diets. Serum triacylglycerol levels were significantly lower and those of HDL (high-density lipoprotein) cholesterol were significantly higher at the end of the MUFA-enriched diet compared with the HCLF diet. It is concluded that the significantly longer lag phase for oxidation of LDL, the higher HDL cholesterol level and the lower triacylglycerol level in subjects following a carotenoid-controlled, MUFA-enriched diet may decrease the risk of coronary heart disease. SN - 0143-5221 UR - https://www.unboundmedicine.com/medline/citation/12780345/Effects_of_two_lipid_lowering_carotenoid_controlled_diets_on_the_oxidative_modification_of_low_density_lipoproteins_in_free_living_humans_ DB - PRIME DP - Unbound Medicine ER -