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A role for indirect allorecognition in lung transplant recipients with obliterative bronchiolitis.
Am J Transplant. 2003 Jun; 3(6):736-42.AJ

Abstract

Obliterative bronchiolitis (OB) occurs in 50% of patients 2 years after lung transplantation. Although a correlation between OB and indirect recognition of donor peptides has been reported, the relative roles of direct vs. indirect recognition have not been investigated. Limiting dilution analysis was used to determine the frequencies of recipient T-helper cells recognizing donor and third-party alloantigens in 19 patients (8 OB positive, 11 OB negative). The assays were designed to distinguish between indirect and direct presentation. In three patients the direct and indirect assay were performed on the same blood sample. Six out of seven patients with OB were hyperresponsive in the indirect pathway to donor antigens compared to third-party, the corresponding figure for OB negative patients being 2/7. In contrast, 5/7 patients were hyporesponsive in the direct pathway; hyporesponsiveness in the direct pathway did not correlate with freedom from OB. The patients in whom the assays were performed from the same blood sample confirmed that donor specific hyperresponsiveness in the indirect route can coexist with donor-specific hyporesponsiveness in the direct route. In conclusion, lung allograft recipients, like recipients of other organ allografts, become hyporesponsive in the direct route but sensitization via the indirect pathway is associated with chronic rejection.

Authors+Show Affiliations

National Heart and Lung Institute, Royal Brompton and Harefield Hospital NHS Trusts, Harefield, Middlesex, UB9 6JH, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12780566

Citation

Stanford, Rachel E., et al. "A Role for Indirect Allorecognition in Lung Transplant Recipients With Obliterative Bronchiolitis." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons, vol. 3, no. 6, 2003, pp. 736-42.
Stanford RE, Ahmed S, Hodson M, et al. A role for indirect allorecognition in lung transplant recipients with obliterative bronchiolitis. Am J Transplant. 2003;3(6):736-42.
Stanford, R. E., Ahmed, S., Hodson, M., Banner, N. R., & Rose, M. L. (2003). A role for indirect allorecognition in lung transplant recipients with obliterative bronchiolitis. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 3(6), 736-42.
Stanford RE, et al. A Role for Indirect Allorecognition in Lung Transplant Recipients With Obliterative Bronchiolitis. Am J Transplant. 2003;3(6):736-42. PubMed PMID: 12780566.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A role for indirect allorecognition in lung transplant recipients with obliterative bronchiolitis. AU - Stanford,Rachel E, AU - Ahmed,Saed, AU - Hodson,Margaret, AU - Banner,Nicholas R, AU - Rose,Marlene L, PY - 2003/6/5/pubmed PY - 2003/9/13/medline PY - 2003/6/5/entrez SP - 736 EP - 42 JF - American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons JO - Am. J. Transplant. VL - 3 IS - 6 N2 - Obliterative bronchiolitis (OB) occurs in 50% of patients 2 years after lung transplantation. Although a correlation between OB and indirect recognition of donor peptides has been reported, the relative roles of direct vs. indirect recognition have not been investigated. Limiting dilution analysis was used to determine the frequencies of recipient T-helper cells recognizing donor and third-party alloantigens in 19 patients (8 OB positive, 11 OB negative). The assays were designed to distinguish between indirect and direct presentation. In three patients the direct and indirect assay were performed on the same blood sample. Six out of seven patients with OB were hyperresponsive in the indirect pathway to donor antigens compared to third-party, the corresponding figure for OB negative patients being 2/7. In contrast, 5/7 patients were hyporesponsive in the direct pathway; hyporesponsiveness in the direct pathway did not correlate with freedom from OB. The patients in whom the assays were performed from the same blood sample confirmed that donor specific hyperresponsiveness in the indirect route can coexist with donor-specific hyporesponsiveness in the direct route. In conclusion, lung allograft recipients, like recipients of other organ allografts, become hyporesponsive in the direct route but sensitization via the indirect pathway is associated with chronic rejection. SN - 1600-6135 UR - https://www.unboundmedicine.com/medline/citation/12780566/A_role_for_indirect_allorecognition_in_lung_transplant_recipients_with_obliterative_bronchiolitis_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1600-6135&date=2003&volume=3&issue=6&spage=736 DB - PRIME DP - Unbound Medicine ER -