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A systematic review and meta-analysis of familial prostate cancer risk.
BJU Int 2003; 91(9):789-94BI

Abstract

OBJECTIVE

To identify published studies quantifying familial prostate cancer risks in relatives of prostate cancer cases and, by meta-analysis, obtain more precise estimates of familial risk according to the family history.

METHODS

Thirteen case-control and cohort studies were identified which have reported risks of prostate cancer in relatives of prostate cancer cases. Pooled estimates of risk for various categories of family history were obtained by calculating the weighted average of the log relative risk (RR) estimates from studies.

RESULTS

The pooled RR (95% confidence interval) in first-degree relatives was 2.5 (2.2-2.8). There was evidence that this was highest in relatives of cases diagnosed before age 60 years and that RRs declined with age. The risk for the few men with two affected relatives was increased 3.5-fold (2.6-4.8). RRs to sons of cases appeared to be lower than in brothers; a complete explanation of this observation is uncertain.

CONCLUSION

Men with a family history of prostate cancer have a significantly greater risk of developing prostate cancer than those with no such history. Risks are greatest for relatives of cases diagnosed when young and those with more than one relative affected.

Authors+Show Affiliations

Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK.No affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

12780833

Citation

Johns, L E., and R S. Houlston. "A Systematic Review and Meta-analysis of Familial Prostate Cancer Risk." BJU International, vol. 91, no. 9, 2003, pp. 789-94.
Johns LE, Houlston RS. A systematic review and meta-analysis of familial prostate cancer risk. BJU Int. 2003;91(9):789-94.
Johns, L. E., & Houlston, R. S. (2003). A systematic review and meta-analysis of familial prostate cancer risk. BJU International, 91(9), pp. 789-94.
Johns LE, Houlston RS. A Systematic Review and Meta-analysis of Familial Prostate Cancer Risk. BJU Int. 2003;91(9):789-94. PubMed PMID: 12780833.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A systematic review and meta-analysis of familial prostate cancer risk. AU - Johns,L E, AU - Houlston,R S, PY - 2003/6/5/pubmed PY - 2003/7/11/medline PY - 2003/6/5/entrez SP - 789 EP - 94 JF - BJU international JO - BJU Int. VL - 91 IS - 9 N2 - OBJECTIVE: To identify published studies quantifying familial prostate cancer risks in relatives of prostate cancer cases and, by meta-analysis, obtain more precise estimates of familial risk according to the family history. METHODS: Thirteen case-control and cohort studies were identified which have reported risks of prostate cancer in relatives of prostate cancer cases. Pooled estimates of risk for various categories of family history were obtained by calculating the weighted average of the log relative risk (RR) estimates from studies. RESULTS: The pooled RR (95% confidence interval) in first-degree relatives was 2.5 (2.2-2.8). There was evidence that this was highest in relatives of cases diagnosed before age 60 years and that RRs declined with age. The risk for the few men with two affected relatives was increased 3.5-fold (2.6-4.8). RRs to sons of cases appeared to be lower than in brothers; a complete explanation of this observation is uncertain. CONCLUSION: Men with a family history of prostate cancer have a significantly greater risk of developing prostate cancer than those with no such history. Risks are greatest for relatives of cases diagnosed when young and those with more than one relative affected. SN - 1464-4096 UR - https://www.unboundmedicine.com/medline/citation/12780833/A_systematic_review_and_meta_analysis_of_familial_prostate_cancer_risk_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1464-4096&date=2003&volume=91&issue=9&spage=789 DB - PRIME DP - Unbound Medicine ER -