Tags

Type your tag names separated by a space and hit enter

Estrogen receptor gene polymorphisms and bone mineral density in Chinese postmenopausal women.
Chin Med J (Engl). 2003 Mar; 116(3):364-7.CM

Abstract

OBJECTIVE

To investigate the relationships between the polymorphisms of estrogen receptor (ER) gene, bone mineral density (BMD) and bone biochemical markers in Chinese postmenopausal women.

METHODS

BMD of lumbar spine and femoral neck were measured using dual-energy X-ray absorptiometry (DEXA) in 186 Chinese postmenopausal women. The PvuII and XbaI polymorphisms of the ER gene were detected using polymerase chain reaction (PCR). Bone biochemical markers, serum alkaline phosphatase, osteocalcin and pyridinoline were measured by ELISA.

RESULTS

The femoral neck (FN) BMD (Z score) was higher in pp compared to Pp (-0.01 +/- 0.12 vs. -0.35 +/- 0.09, P < 0.05) while lumbar spine BMD (Z score) was higher in XX type compared to Xx and xx genotypes (0.01 +/- 0.45 vs -1.53 +/- 0.17, -1.29 +/- 0.10, < 0.001 and 0.001, respectively). Women without Px haplotype (n = 79) had a higher BMD Z-score for the lumbar spine (-1.03 +/- 0.14 vs -1.45 +/- 0.11, P < 0.05) and femoral neck (-0.01 +/- 0.11 vs -0.31 +/- 0.09, P < 0.05) than those who had it (n = 107).

CONCLUSIONS

The present study suggested that the pp and XX genotypes of ER gene might play a certain role in maintaining FN and lumbar spine BMD. ER genotypes without Px haplotype might be favorable to bone mass, while those with it might exert some harmful effect on bone mineral density.

Authors+Show Affiliations

Department of Endocrinology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China. ljmhh@public7.sta.net.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12781038

Citation

Liu, Jianmin, et al. "Estrogen Receptor Gene Polymorphisms and Bone Mineral Density in Chinese Postmenopausal Women." Chinese Medical Journal, vol. 116, no. 3, 2003, pp. 364-7.
Liu J, Zhu H, Zhu X, et al. Estrogen receptor gene polymorphisms and bone mineral density in Chinese postmenopausal women. Chin Med J (Engl). 2003;116(3):364-7.
Liu, J., Zhu, H., Zhu, X., Dai, M., Jiang, L., Xu, M., & Chen, J. (2003). Estrogen receptor gene polymorphisms and bone mineral density in Chinese postmenopausal women. Chinese Medical Journal, 116(3), 364-7.
Liu J, et al. Estrogen Receptor Gene Polymorphisms and Bone Mineral Density in Chinese Postmenopausal Women. Chin Med J (Engl). 2003;116(3):364-7. PubMed PMID: 12781038.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Estrogen receptor gene polymorphisms and bone mineral density in Chinese postmenopausal women. AU - Liu,Jianmin, AU - Zhu,Hanmin, AU - Zhu,Xiaoying, AU - Dai,Meng, AU - Jiang,Ling, AU - Xu,Manyin, AU - Chen,Jialun, PY - 2003/6/5/pubmed PY - 2003/7/11/medline PY - 2003/6/5/entrez SP - 364 EP - 7 JF - Chinese medical journal JO - Chin Med J (Engl) VL - 116 IS - 3 N2 - OBJECTIVE: To investigate the relationships between the polymorphisms of estrogen receptor (ER) gene, bone mineral density (BMD) and bone biochemical markers in Chinese postmenopausal women. METHODS: BMD of lumbar spine and femoral neck were measured using dual-energy X-ray absorptiometry (DEXA) in 186 Chinese postmenopausal women. The PvuII and XbaI polymorphisms of the ER gene were detected using polymerase chain reaction (PCR). Bone biochemical markers, serum alkaline phosphatase, osteocalcin and pyridinoline were measured by ELISA. RESULTS: The femoral neck (FN) BMD (Z score) was higher in pp compared to Pp (-0.01 +/- 0.12 vs. -0.35 +/- 0.09, P < 0.05) while lumbar spine BMD (Z score) was higher in XX type compared to Xx and xx genotypes (0.01 +/- 0.45 vs -1.53 +/- 0.17, -1.29 +/- 0.10, < 0.001 and 0.001, respectively). Women without Px haplotype (n = 79) had a higher BMD Z-score for the lumbar spine (-1.03 +/- 0.14 vs -1.45 +/- 0.11, P < 0.05) and femoral neck (-0.01 +/- 0.11 vs -0.31 +/- 0.09, P < 0.05) than those who had it (n = 107). CONCLUSIONS: The present study suggested that the pp and XX genotypes of ER gene might play a certain role in maintaining FN and lumbar spine BMD. ER genotypes without Px haplotype might be favorable to bone mass, while those with it might exert some harmful effect on bone mineral density. SN - 0366-6999 UR - https://www.unboundmedicine.com/medline/citation/12781038/Estrogen_receptor_gene_polymorphisms_and_bone_mineral_density_in_Chinese_postmenopausal_women_ L2 - https://medlineplus.gov/bonedensity.html DB - PRIME DP - Unbound Medicine ER -