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Amplification of the BCR/ABL fusion gene clustered on a masked Philadelphia chromosome in a patient with myeloblastic crisis of chronic myelocytic leukemia.
Cancer Genet Cytogenet 2003; 143(2):140-4CG

Abstract

Although the chronic phase of chronic myelocytic leukemia (CML) is characterized by the Philadelphia (Ph) chromosome creating a hybrid BCR/ABL gene, additional genetic changes involved in blast crisis are poorly understood. We report a 4-8-fold amplification by tandem duplication of the BCR/ABL fusion gene clustered on a masked Ph chromosome in a 61-year-old male patient with CML in myeloblastic crisis. Our finding suggests that the BCR/ABL amplification may play a role as a novel mechanism in the progression to an aggressive blast transformation in some cases of Ph-positive CML.

Authors+Show Affiliations

Departamento de Genética, Academia Nacional de Medicina de Buenos Aires, Buenos Aires, Argentina.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

12781448

Citation

Gargallo, Patricia M., et al. "Amplification of the BCR/ABL Fusion Gene Clustered On a Masked Philadelphia Chromosome in a Patient With Myeloblastic Crisis of Chronic Myelocytic Leukemia." Cancer Genetics and Cytogenetics, vol. 143, no. 2, 2003, pp. 140-4.
Gargallo PM, Cuello MT, Aranguren PN, et al. Amplification of the BCR/ABL fusion gene clustered on a masked Philadelphia chromosome in a patient with myeloblastic crisis of chronic myelocytic leukemia. Cancer Genet Cytogenet. 2003;143(2):140-4.
Gargallo, P. M., Cuello, M. T., Aranguren, P. N., & Larripa, I. B. (2003). Amplification of the BCR/ABL fusion gene clustered on a masked Philadelphia chromosome in a patient with myeloblastic crisis of chronic myelocytic leukemia. Cancer Genetics and Cytogenetics, 143(2), pp. 140-4.
Gargallo PM, et al. Amplification of the BCR/ABL Fusion Gene Clustered On a Masked Philadelphia Chromosome in a Patient With Myeloblastic Crisis of Chronic Myelocytic Leukemia. Cancer Genet Cytogenet. 2003;143(2):140-4. PubMed PMID: 12781448.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Amplification of the BCR/ABL fusion gene clustered on a masked Philadelphia chromosome in a patient with myeloblastic crisis of chronic myelocytic leukemia. AU - Gargallo,Patricia M, AU - Cuello,Maria Teresa, AU - Aranguren,Pedro Negri, AU - Larripa,Irene B, PY - 2003/6/5/pubmed PY - 2003/6/28/medline PY - 2003/6/5/entrez SP - 140 EP - 4 JF - Cancer genetics and cytogenetics JO - Cancer Genet. Cytogenet. VL - 143 IS - 2 N2 - Although the chronic phase of chronic myelocytic leukemia (CML) is characterized by the Philadelphia (Ph) chromosome creating a hybrid BCR/ABL gene, additional genetic changes involved in blast crisis are poorly understood. We report a 4-8-fold amplification by tandem duplication of the BCR/ABL fusion gene clustered on a masked Ph chromosome in a 61-year-old male patient with CML in myeloblastic crisis. Our finding suggests that the BCR/ABL amplification may play a role as a novel mechanism in the progression to an aggressive blast transformation in some cases of Ph-positive CML. SN - 0165-4608 UR - https://www.unboundmedicine.com/medline/citation/12781448/Amplification_of_the_BCR/ABL_fusion_gene_clustered_on_a_masked_Philadelphia_chromosome_in_a_patient_with_myeloblastic_crisis_of_chronic_myelocytic_leukemia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165460802008543 DB - PRIME DP - Unbound Medicine ER -