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Amplification of the BCR/ABL fusion gene clustered on a masked Philadelphia chromosome in a patient with myeloblastic crisis of chronic myelocytic leukemia.

Abstract

Although the chronic phase of chronic myelocytic leukemia (CML) is characterized by the Philadelphia (Ph) chromosome creating a hybrid BCR/ABL gene, additional genetic changes involved in blast crisis are poorly understood. We report a 4-8-fold amplification by tandem duplication of the BCR/ABL fusion gene clustered on a masked Ph chromosome in a 61-year-old male patient with CML in myeloblastic crisis. Our finding suggests that the BCR/ABL amplification may play a role as a novel mechanism in the progression to an aggressive blast transformation in some cases of Ph-positive CML.

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  • Authors+Show Affiliations

    ,

    Departamento de Genética, Academia Nacional de Medicina de Buenos Aires, Buenos Aires, Argentina.

    , ,

    Source

    Cancer genetics and cytogenetics 143:2 2003 Jun pg 140-4

    MeSH

    Fusion Proteins, bcr-abl
    Gene Amplification
    Humans
    In Situ Hybridization, Fluorescence
    Leukemia, Myelogenous, Chronic, BCR-ABL Positive
    Male
    Middle Aged
    Multigene Family
    Philadelphia Chromosome

    Pub Type(s)

    Case Reports
    Journal Article

    Language

    eng

    PubMed ID

    12781448

    Citation

    Gargallo, Patricia M., et al. "Amplification of the BCR/ABL Fusion Gene Clustered On a Masked Philadelphia Chromosome in a Patient With Myeloblastic Crisis of Chronic Myelocytic Leukemia." Cancer Genetics and Cytogenetics, vol. 143, no. 2, 2003, pp. 140-4.
    Gargallo PM, Cuello MT, Aranguren PN, et al. Amplification of the BCR/ABL fusion gene clustered on a masked Philadelphia chromosome in a patient with myeloblastic crisis of chronic myelocytic leukemia. Cancer Genet Cytogenet. 2003;143(2):140-4.
    Gargallo, P. M., Cuello, M. T., Aranguren, P. N., & Larripa, I. B. (2003). Amplification of the BCR/ABL fusion gene clustered on a masked Philadelphia chromosome in a patient with myeloblastic crisis of chronic myelocytic leukemia. Cancer Genetics and Cytogenetics, 143(2), pp. 140-4.
    Gargallo PM, et al. Amplification of the BCR/ABL Fusion Gene Clustered On a Masked Philadelphia Chromosome in a Patient With Myeloblastic Crisis of Chronic Myelocytic Leukemia. Cancer Genet Cytogenet. 2003;143(2):140-4. PubMed PMID: 12781448.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Amplification of the BCR/ABL fusion gene clustered on a masked Philadelphia chromosome in a patient with myeloblastic crisis of chronic myelocytic leukemia. AU - Gargallo,Patricia M, AU - Cuello,Maria Teresa, AU - Aranguren,Pedro Negri, AU - Larripa,Irene B, PY - 2003/6/5/pubmed PY - 2003/6/28/medline PY - 2003/6/5/entrez SP - 140 EP - 4 JF - Cancer genetics and cytogenetics JO - Cancer Genet. Cytogenet. VL - 143 IS - 2 N2 - Although the chronic phase of chronic myelocytic leukemia (CML) is characterized by the Philadelphia (Ph) chromosome creating a hybrid BCR/ABL gene, additional genetic changes involved in blast crisis are poorly understood. We report a 4-8-fold amplification by tandem duplication of the BCR/ABL fusion gene clustered on a masked Ph chromosome in a 61-year-old male patient with CML in myeloblastic crisis. Our finding suggests that the BCR/ABL amplification may play a role as a novel mechanism in the progression to an aggressive blast transformation in some cases of Ph-positive CML. SN - 0165-4608 UR - https://www.unboundmedicine.com/medline/citation/12781448/Amplification_of_the_BCR/ABL_fusion_gene_clustered_on_a_masked_Philadelphia_chromosome_in_a_patient_with_myeloblastic_crisis_of_chronic_myelocytic_leukemia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165460802008543 DB - PRIME DP - Unbound Medicine ER -