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Simultaneous determination of dopamine and serotonin on a glassy carbon electrode coated with a film of carbon nanotubes.
Anal Biochem. 2003 Jul 01; 318(1):100-6.AB

Abstract

A chemically modified electrode based on the carbon nanotube film-coated glassy carbon electrode (GCE) is described for the simultaneous determination of dopamine (DA) and serotonin (5-HT). The multiwall carbon nanotube (MWNT) film-coated GCE exhibits a marked enhancement effect on the current response of DA and 5-HT and lowers oxidation overpotentials. The responses of DA and 5-HT merge into a large peak at a bare GCE, but they yield two well-defined oxidation peaks at the MWNT film-coated GCE. The experimental parameters were optimized, and a direct electrochemical method for the simultaneous determination of DA and 5-HT was proposed. The interference of ascorbic acid (AA) was investigated, and the results showed that a large excess of AA did not interfere with the voltammetric responses of DA and 5-HT. The modified electrode has been successfully applied for the assay of 5-HT and DA in human blood serum.

Authors+Show Affiliations

Wu K
Department of Chemistry, Wuhan University, Wuhan 430072, China.
Fei J
No affiliation info available
Hu S
No affiliation info available

MeSH

AdsorptionAscorbic AcidCarbonDopamineElectrochemistryElectrodesHumansHydrogen-Ion ConcentrationNanotechnologyNanotubes, CarbonOrganophosphatesOxidation-ReductionReproducibility of ResultsSerotoninUric Acid

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12782037

Citation

Wu, Kangbing, et al. "Simultaneous Determination of Dopamine and Serotonin On a Glassy Carbon Electrode Coated With a Film of Carbon Nanotubes." Analytical Biochemistry, vol. 318, no. 1, 2003, pp. 100-6.
Wu K, Fei J, Hu S. Simultaneous determination of dopamine and serotonin on a glassy carbon electrode coated with a film of carbon nanotubes. Anal Biochem. 2003;318(1):100-6.
Wu, K., Fei, J., & Hu, S. (2003). Simultaneous determination of dopamine and serotonin on a glassy carbon electrode coated with a film of carbon nanotubes. Analytical Biochemistry, 318(1), 100-6.
Wu K, Fei J, Hu S. Simultaneous Determination of Dopamine and Serotonin On a Glassy Carbon Electrode Coated With a Film of Carbon Nanotubes. Anal Biochem. 2003 Jul 1;318(1):100-6. PubMed PMID: 12782037.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simultaneous determination of dopamine and serotonin on a glassy carbon electrode coated with a film of carbon nanotubes. AU - Wu,Kangbing, AU - Fei,Junjie, AU - Hu,Shengshui, PY - 2003/6/5/pubmed PY - 2004/10/22/medline PY - 2003/6/5/entrez SP - 100 EP - 6 JF - Analytical biochemistry JO - Anal Biochem VL - 318 IS - 1 N2 - A chemically modified electrode based on the carbon nanotube film-coated glassy carbon electrode (GCE) is described for the simultaneous determination of dopamine (DA) and serotonin (5-HT). The multiwall carbon nanotube (MWNT) film-coated GCE exhibits a marked enhancement effect on the current response of DA and 5-HT and lowers oxidation overpotentials. The responses of DA and 5-HT merge into a large peak at a bare GCE, but they yield two well-defined oxidation peaks at the MWNT film-coated GCE. The experimental parameters were optimized, and a direct electrochemical method for the simultaneous determination of DA and 5-HT was proposed. The interference of ascorbic acid (AA) was investigated, and the results showed that a large excess of AA did not interfere with the voltammetric responses of DA and 5-HT. The modified electrode has been successfully applied for the assay of 5-HT and DA in human blood serum. SN - 0003-2697 UR - https://www.unboundmedicine.com/medline/citation/12782037/Simultaneous_determination_of_dopamine_and_serotonin_on_a_glassy_carbon_electrode_coated_with_a_film_of_carbon_nanotubes_ DB - PRIME DP - Unbound Medicine ER -
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