Tags

Type your tag names separated by a space and hit enter

Human kallikrein 8, a novel biomarker for ovarian carcinoma.
Cancer Res. 2003 Jun 01; 63(11):2771-4.CR

Abstract

Human kallikrein 8 (hK8; neuropsin) is a serine protease and new member of the hK family. The aim of this study was to examine if hK8 may serve as a novel cancer biomarker. An hk8-ELISA, developed in-house, was used to study the distribution of hK8 in various biological fluids and tissue extracts from healthy individuals and ovarian cancer patients of different stages of the disease (International Federation of Obstetrics and Gynecology II-IV). For ovarian cancer patients, very high levels in ascites fluid were observed (<or=1000 microg/liter; n = 85 samples). Elevated serum levels were seen in 24 of 40 (62%) of ovarian cancer patients. Higher ascites fluid hK8 concentration was associated with better ovarian cancer progression-free survival (P = 0.02). In both serum and ascites fluid, there is a significant correlation between hK8 and CA125 concentration (r = 0.51 and 0.58, respectively). The serum concentration of hK8 was an indicator of progression on regression on longitudinal monitoring of an ovarian cancer patient. These data suggest that hK8 protein is detectable in ovarian cancer tissue extracts, serum, and ascites fluid, indicating that it may serve as a new ovarian cancer marker.

Authors+Show Affiliations

Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12782581

Citation

Kishi, Tadaaki, et al. "Human Kallikrein 8, a Novel Biomarker for Ovarian Carcinoma." Cancer Research, vol. 63, no. 11, 2003, pp. 2771-4.
Kishi T, Grass L, Soosaipillai A, et al. Human kallikrein 8, a novel biomarker for ovarian carcinoma. Cancer Res. 2003;63(11):2771-4.
Kishi, T., Grass, L., Soosaipillai, A., Scorilas, A., Harbeck, N., Schmalfeldt, B., Dorn, J., Mysliwiec, M., Schmitt, M., & Diamandis, E. P. (2003). Human kallikrein 8, a novel biomarker for ovarian carcinoma. Cancer Research, 63(11), 2771-4.
Kishi T, et al. Human Kallikrein 8, a Novel Biomarker for Ovarian Carcinoma. Cancer Res. 2003 Jun 1;63(11):2771-4. PubMed PMID: 12782581.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human kallikrein 8, a novel biomarker for ovarian carcinoma. AU - Kishi,Tadaaki, AU - Grass,Linda, AU - Soosaipillai,Antoninus, AU - Scorilas,Andreas, AU - Harbeck,Nadia, AU - Schmalfeldt,Barbara, AU - Dorn,Julia, AU - Mysliwiec,Michal, AU - Schmitt,Manfred, AU - Diamandis,Eleftherios P, PY - 2003/6/5/pubmed PY - 2003/8/2/medline PY - 2003/6/5/entrez SP - 2771 EP - 4 JF - Cancer research JO - Cancer Res. VL - 63 IS - 11 N2 - Human kallikrein 8 (hK8; neuropsin) is a serine protease and new member of the hK family. The aim of this study was to examine if hK8 may serve as a novel cancer biomarker. An hk8-ELISA, developed in-house, was used to study the distribution of hK8 in various biological fluids and tissue extracts from healthy individuals and ovarian cancer patients of different stages of the disease (International Federation of Obstetrics and Gynecology II-IV). For ovarian cancer patients, very high levels in ascites fluid were observed (<or=1000 microg/liter; n = 85 samples). Elevated serum levels were seen in 24 of 40 (62%) of ovarian cancer patients. Higher ascites fluid hK8 concentration was associated with better ovarian cancer progression-free survival (P = 0.02). In both serum and ascites fluid, there is a significant correlation between hK8 and CA125 concentration (r = 0.51 and 0.58, respectively). The serum concentration of hK8 was an indicator of progression on regression on longitudinal monitoring of an ovarian cancer patient. These data suggest that hK8 protein is detectable in ovarian cancer tissue extracts, serum, and ascites fluid, indicating that it may serve as a new ovarian cancer marker. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/12782581/Human_kallikrein_8_a_novel_biomarker_for_ovarian_carcinoma_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=12782581 DB - PRIME DP - Unbound Medicine ER -