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Apomorphine infusion and the long-duration response to levodopa in advanced Parkinson's disease.
Clin Neuropharmacol. 2003 May-Jun; 26(3):151-5.CN

Abstract

The authors investigated the long-duration response to levodopa in advanced Parkinson's disease. Eight patients with advanced Parkinson's disease disabled by severe ON/OFF fluctuations treated by chronic daytime subcutaneous apomorphine infusion with supplemental oral levodopa were studied. On day 1, oral levodopa was withdrawn at 4:00 pm and on the following morning subcutaneous apomorphine infusion was continued at the same rate without levodopa therapy. While receiving apomorphine alone, seven of the eight patients turned ON, and their usual dyskinesias returned. The ON phase persisted for 60 to 100 minutes (mean, 185.7 minutes) but then, despite continued, constant-rate apomorphine infusion to stabilize plasma levels, switched to an OFF phase. The authors conclude that the clinical effect of apomorphine is sustained by levodopa long-duration response. This effect is probably the result of postsynaptic mechanisms. In patients with advanced Parkinson's disease, the long-duration response to levodopa is present although slightly diminished.

Authors+Show Affiliations

Institute of Neurology IRCCS "NEUROMED," Pozzilli, Rome, Italy. fabrizio.stocchi@tin.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article

Language

eng

PubMed ID

12782918

Citation

Stocchi, Fabrizio, et al. "Apomorphine Infusion and the Long-duration Response to Levodopa in Advanced Parkinson's Disease." Clinical Neuropharmacology, vol. 26, no. 3, 2003, pp. 151-5.
Stocchi F, Berardelli A, Vacca L, et al. Apomorphine infusion and the long-duration response to levodopa in advanced Parkinson's disease. Clin Neuropharmacol. 2003;26(3):151-5.
Stocchi, F., Berardelli, A., Vacca, L., Barbato, L., Monge, A., Nordera, G., & Ruggieri, S. (2003). Apomorphine infusion and the long-duration response to levodopa in advanced Parkinson's disease. Clinical Neuropharmacology, 26(3), 151-5.
Stocchi F, et al. Apomorphine Infusion and the Long-duration Response to Levodopa in Advanced Parkinson's Disease. Clin Neuropharmacol. 2003 May-Jun;26(3):151-5. PubMed PMID: 12782918.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apomorphine infusion and the long-duration response to levodopa in advanced Parkinson's disease. AU - Stocchi,Fabrizio, AU - Berardelli,Alfredo, AU - Vacca,Laura, AU - Barbato,Luca, AU - Monge,Alessandra, AU - Nordera,Giampietro, AU - Ruggieri,Stefano, PY - 2003/6/5/pubmed PY - 2003/7/25/medline PY - 2003/6/5/entrez SP - 151 EP - 5 JF - Clinical neuropharmacology JO - Clin Neuropharmacol VL - 26 IS - 3 N2 - The authors investigated the long-duration response to levodopa in advanced Parkinson's disease. Eight patients with advanced Parkinson's disease disabled by severe ON/OFF fluctuations treated by chronic daytime subcutaneous apomorphine infusion with supplemental oral levodopa were studied. On day 1, oral levodopa was withdrawn at 4:00 pm and on the following morning subcutaneous apomorphine infusion was continued at the same rate without levodopa therapy. While receiving apomorphine alone, seven of the eight patients turned ON, and their usual dyskinesias returned. The ON phase persisted for 60 to 100 minutes (mean, 185.7 minutes) but then, despite continued, constant-rate apomorphine infusion to stabilize plasma levels, switched to an OFF phase. The authors conclude that the clinical effect of apomorphine is sustained by levodopa long-duration response. This effect is probably the result of postsynaptic mechanisms. In patients with advanced Parkinson's disease, the long-duration response to levodopa is present although slightly diminished. SN - 0362-5664 UR - https://www.unboundmedicine.com/medline/citation/12782918/Apomorphine_infusion_and_the_long_duration_response_to_levodopa_in_advanced_Parkinson's_disease_ L2 - https://doi.org/10.1097/00002826-200305000-00009 DB - PRIME DP - Unbound Medicine ER -