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Effects of THC on behavioral measures of impulsivity in humans.
Neuropsychopharmacology. 2003 Jul; 28(7):1356-65.N

Abstract

This study investigated the acute effects of delta(9)-tetrahydrocannabinol (THC) on four behavioral measures of impulsivity in recreational marijuana users. Although impulsive behavior has been studied using several different measures of impulsivity, few studies have utilized more than one of these measures on a single cohort. In this study, 37 healthy men and women participated in three sessions, in which they received capsules containing placebo, 7.5, or 15 mg THC in randomized order under double-blind conditions. Subjects were tested on the following four tasks: the Stop task, which measures the ability to inhibit a prepotent motor response; a Go/no-go task; a Delay discounting task, which measures the value of delayed or uncertain reinforcers; and a time estimation task, which measures alterations in time perception through a time reproduction procedure. Subjects also completed mood questionnaires and general measures of performance. THC produced its expected effects on subjective measures including increases in ARCI euphoria and marijuana scales. THC increased impulsive responding on the Stop task but did not affect performance on either the Go/no-go or Delay or Probability discounting tasks. On the time reproduction task, THC increased estimates of the duration of short intervals while not affecting estimates of longer intervals. There were no significant correlations between the four tasks either before or after drug administration. These results suggest that THC may increase certain forms of impulsive behavior while not affecting other impulsive behaviors. The dissociations between the four measures of impulsivity suggest that impulsivity is an assemblage of distinct components rather than a unitary process.

Authors+Show Affiliations

Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

12784123

Citation

McDonald, Jennifer, et al. "Effects of THC On Behavioral Measures of Impulsivity in Humans." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, vol. 28, no. 7, 2003, pp. 1356-65.
McDonald J, Schleifer L, Richards JB, et al. Effects of THC on behavioral measures of impulsivity in humans. Neuropsychopharmacology. 2003;28(7):1356-65.
McDonald, J., Schleifer, L., Richards, J. B., & de Wit, H. (2003). Effects of THC on behavioral measures of impulsivity in humans. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 28(7), 1356-65.
McDonald J, et al. Effects of THC On Behavioral Measures of Impulsivity in Humans. Neuropsychopharmacology. 2003;28(7):1356-65. PubMed PMID: 12784123.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of THC on behavioral measures of impulsivity in humans. AU - McDonald,Jennifer, AU - Schleifer,Laura, AU - Richards,Jerry B, AU - de Wit,Harriet, Y1 - 2003/04/30/ PY - 2003/6/5/pubmed PY - 2003/9/3/medline PY - 2003/6/5/entrez SP - 1356 EP - 65 JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology JO - Neuropsychopharmacology VL - 28 IS - 7 N2 - This study investigated the acute effects of delta(9)-tetrahydrocannabinol (THC) on four behavioral measures of impulsivity in recreational marijuana users. Although impulsive behavior has been studied using several different measures of impulsivity, few studies have utilized more than one of these measures on a single cohort. In this study, 37 healthy men and women participated in three sessions, in which they received capsules containing placebo, 7.5, or 15 mg THC in randomized order under double-blind conditions. Subjects were tested on the following four tasks: the Stop task, which measures the ability to inhibit a prepotent motor response; a Go/no-go task; a Delay discounting task, which measures the value of delayed or uncertain reinforcers; and a time estimation task, which measures alterations in time perception through a time reproduction procedure. Subjects also completed mood questionnaires and general measures of performance. THC produced its expected effects on subjective measures including increases in ARCI euphoria and marijuana scales. THC increased impulsive responding on the Stop task but did not affect performance on either the Go/no-go or Delay or Probability discounting tasks. On the time reproduction task, THC increased estimates of the duration of short intervals while not affecting estimates of longer intervals. There were no significant correlations between the four tasks either before or after drug administration. These results suggest that THC may increase certain forms of impulsive behavior while not affecting other impulsive behaviors. The dissociations between the four measures of impulsivity suggest that impulsivity is an assemblage of distinct components rather than a unitary process. SN - 0893-133X UR - https://www.unboundmedicine.com/medline/citation/12784123/Effects_of_THC_on_behavioral_measures_of_impulsivity_in_humans_ L2 - http://dx.doi.org/10.1038/sj.npp.1300176 DB - PRIME DP - Unbound Medicine ER -