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Efficacy of radiation therapy in the local control of desmoplastic malignant melanoma.
Head Neck. 2003 Jun; 25(6):423-8.HN

Abstract

BACKGROUND

Desmoplastic malignant melanoma (DMM) is a rare variant of malignant melanoma with high local recurrence rate after surgical excision. We performed a retrospective review to address the role of radiation therapy in local control of this tumor.

METHODS

Between 1976 and 1997, 44 patients with the pathologic diagnosis of DMM were registered at our tumor registry. Fourteen patients received postoperative RT, and one patient received preoperative RT. Three of the irradiated lesions had gross residual or positive surgical margins. Doses ranged from 44 to 66 Gy.

RESULTS

Sixty-eight percent of DMM lesions occurred in the head and neck region. Forty-eight percent (21 of 44) of patients experienced a local recurrence after initial excision (mean time to recurrence, 12 months). Local failure in head and neck was 46% (14 of 30). Clark level, primary site, and neurotropism did not predict local recurrence; the Clark level predicted distant metastasis. No viable tumor was found in the surgical specimen of the patient who received preoperative RT. None of 15 patients who received adjuvant irradiation had any additional recurrences (mean follow-up, 64.7 months). By contrast, four of seven patients with history of recurrence who did not receive RT had local relapse (p =.005). The incidence of distant metastasis did not reach statistical significance between the irradiated and nonirradiated groups.

CONCLUSIONS

The high rate of local recurrence of DMM after surgical resection is dramatically reduced by adjuvant radiation therapy. We recommend adjuvant postoperative radiation therapy as a part of treatment of DMM.

Authors+Show Affiliations

Department of Radiation Oncology, University of California, 200 UCLA Medical Plaza, Suite B265, Los Angeles, California 90024, USA. vongtama@radonc.ucla.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12784232

Citation

Vongtama, Roy, et al. "Efficacy of Radiation Therapy in the Local Control of Desmoplastic Malignant Melanoma." Head & Neck, vol. 25, no. 6, 2003, pp. 423-8.
Vongtama R, Safa A, Gallardo D, et al. Efficacy of radiation therapy in the local control of desmoplastic malignant melanoma. Head Neck. 2003;25(6):423-8.
Vongtama, R., Safa, A., Gallardo, D., Calcaterra, T., & Juillard, G. (2003). Efficacy of radiation therapy in the local control of desmoplastic malignant melanoma. Head & Neck, 25(6), 423-8.
Vongtama R, et al. Efficacy of Radiation Therapy in the Local Control of Desmoplastic Malignant Melanoma. Head Neck. 2003;25(6):423-8. PubMed PMID: 12784232.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of radiation therapy in the local control of desmoplastic malignant melanoma. AU - Vongtama,Roy, AU - Safa,Afshin, AU - Gallardo,David, AU - Calcaterra,Thomas, AU - Juillard,Guy, PY - 2003/6/5/pubmed PY - 2003/10/16/medline PY - 2003/6/5/entrez SP - 423 EP - 8 JF - Head & neck JO - Head Neck VL - 25 IS - 6 N2 - BACKGROUND: Desmoplastic malignant melanoma (DMM) is a rare variant of malignant melanoma with high local recurrence rate after surgical excision. We performed a retrospective review to address the role of radiation therapy in local control of this tumor. METHODS: Between 1976 and 1997, 44 patients with the pathologic diagnosis of DMM were registered at our tumor registry. Fourteen patients received postoperative RT, and one patient received preoperative RT. Three of the irradiated lesions had gross residual or positive surgical margins. Doses ranged from 44 to 66 Gy. RESULTS: Sixty-eight percent of DMM lesions occurred in the head and neck region. Forty-eight percent (21 of 44) of patients experienced a local recurrence after initial excision (mean time to recurrence, 12 months). Local failure in head and neck was 46% (14 of 30). Clark level, primary site, and neurotropism did not predict local recurrence; the Clark level predicted distant metastasis. No viable tumor was found in the surgical specimen of the patient who received preoperative RT. None of 15 patients who received adjuvant irradiation had any additional recurrences (mean follow-up, 64.7 months). By contrast, four of seven patients with history of recurrence who did not receive RT had local relapse (p =.005). The incidence of distant metastasis did not reach statistical significance between the irradiated and nonirradiated groups. CONCLUSIONS: The high rate of local recurrence of DMM after surgical resection is dramatically reduced by adjuvant radiation therapy. We recommend adjuvant postoperative radiation therapy as a part of treatment of DMM. SN - 1043-3074 UR - https://www.unboundmedicine.com/medline/citation/12784232/Efficacy_of_radiation_therapy_in_the_local_control_of_desmoplastic_malignant_melanoma_ L2 - https://doi.org/10.1002/hed.10263 DB - PRIME DP - Unbound Medicine ER -