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Suppression of fatty acid synthase by dietary polyunsaturated fatty acids is mediated by fat itself, not by peroxidative mechanism.
J Biochem Mol Biol. 2003 May 31; 36(3):258-64.JB

Abstract

This study examined the effect of dietary polyunsaturated fatty acids (PUFA) that were supplemented with vitamin E on lipid peroxidation, glutathione-dependent detoxifying enzyme system activity, and lipogenic fatty acid synthase (FAS) expression in rat liver. Male Sprague-Dawley rats were fed semipurified diets containing either 1% (w/w) corn oil or 10% each of beef tallow, corn oil, perilla oil, and fish oil for 4 wk. Alpha-tocopherol was supplemented in perilla oil (0.015%) and fish oil (0.019%). Hepatic thiobarbituric acid reactive substances, an estimate of lipid peroxidation, were not significantly different among the dietary groups. The glutathione peroxidase, glutathione reductase, and glutathione S-transferase activities were all elevated by the polyunsaturated fats, especially fish oil. The activity of FAS was reduced in the polyunsaturated fat-fed groups in the order of fish oil, perilla oil, and corn oil. The mRNA contents decreased in rats that were fed the 10% fat diets, particularly polyunsaturated fats, compared with the rats that were fed the 1% corn oil diet. Similarly, the inhibitory effect was the greatest in fish oil. These results suggest that lipid peroxidation can be minimized by vitamin E; PUFA in itself has a suppressive effect on lipogenic enzyme.

Authors+Show Affiliations

Department of Food and Nutrition, Seoul National University, Seoul 151-742, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12787479

Citation

Kim, Hyekyeong, et al. "Suppression of Fatty Acid Synthase By Dietary Polyunsaturated Fatty Acids Is Mediated By Fat Itself, Not By Peroxidative Mechanism." Journal of Biochemistry and Molecular Biology, vol. 36, no. 3, 2003, pp. 258-64.
Kim H, Choi S, Lee HJ, et al. Suppression of fatty acid synthase by dietary polyunsaturated fatty acids is mediated by fat itself, not by peroxidative mechanism. J Biochem Mol Biol. 2003;36(3):258-64.
Kim, H., Choi, S., Lee, H. J., Lee, J. H., & Choi, H. (2003). Suppression of fatty acid synthase by dietary polyunsaturated fatty acids is mediated by fat itself, not by peroxidative mechanism. Journal of Biochemistry and Molecular Biology, 36(3), 258-64.
Kim H, et al. Suppression of Fatty Acid Synthase By Dietary Polyunsaturated Fatty Acids Is Mediated By Fat Itself, Not By Peroxidative Mechanism. J Biochem Mol Biol. 2003 May 31;36(3):258-64. PubMed PMID: 12787479.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Suppression of fatty acid synthase by dietary polyunsaturated fatty acids is mediated by fat itself, not by peroxidative mechanism. AU - Kim,Hyekyeong, AU - Choi,Sungwon, AU - Lee,Hae-Jeung, AU - Lee,Joo-Hee, AU - Choi,Haymie, PY - 2003/6/6/pubmed PY - 2004/2/14/medline PY - 2003/6/6/entrez SP - 258 EP - 64 JF - Journal of biochemistry and molecular biology JO - J Biochem Mol Biol VL - 36 IS - 3 N2 - This study examined the effect of dietary polyunsaturated fatty acids (PUFA) that were supplemented with vitamin E on lipid peroxidation, glutathione-dependent detoxifying enzyme system activity, and lipogenic fatty acid synthase (FAS) expression in rat liver. Male Sprague-Dawley rats were fed semipurified diets containing either 1% (w/w) corn oil or 10% each of beef tallow, corn oil, perilla oil, and fish oil for 4 wk. Alpha-tocopherol was supplemented in perilla oil (0.015%) and fish oil (0.019%). Hepatic thiobarbituric acid reactive substances, an estimate of lipid peroxidation, were not significantly different among the dietary groups. The glutathione peroxidase, glutathione reductase, and glutathione S-transferase activities were all elevated by the polyunsaturated fats, especially fish oil. The activity of FAS was reduced in the polyunsaturated fat-fed groups in the order of fish oil, perilla oil, and corn oil. The mRNA contents decreased in rats that were fed the 10% fat diets, particularly polyunsaturated fats, compared with the rats that were fed the 1% corn oil diet. Similarly, the inhibitory effect was the greatest in fish oil. These results suggest that lipid peroxidation can be minimized by vitamin E; PUFA in itself has a suppressive effect on lipogenic enzyme. SN - 1225-8687 UR - https://www.unboundmedicine.com/medline/citation/12787479/Suppression_of_fatty_acid_synthase_by_dietary_polyunsaturated_fatty_acids_is_mediated_by_fat_itself_not_by_peroxidative_mechanism_ L2 - https://antibodies.cancer.gov/detail/CPTC-FAS-1 DB - PRIME DP - Unbound Medicine ER -