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Depressive symptoms and the risk of type 2 diabetes mellitus in a US sample.
Diabetes Metab Res Rev 2003 May-Jun; 19(3):202-8DM

Abstract

OBJECTIVE

There is some evidence to suggest that individuals with depression are at an almost twofold increased risk of developing type 2 diabetes mellitus, but results are far from conclusive. Therefore, to determine if depressive symptoms increased the risk of type 2 diabetes, we conducted longitudinal analyses using data from the NHANES I Epidemiologic Follow-up Survey (NHEFS).

RESEARCH DESIGN AND METHODS

Participants included individuals who were white or African-American, did not report previous diagnosis of diabetes, and who completed the Centers for Epidemiologic Studies Depression (CES-D) questionnaire in the 1982-1984 study (n = 8870). Participants were followed up for incident-diagnosed diabetes through 1992 (mean follow-up 9.0 years).

RESULTS

There were 1444 (15.9%) participants with high depressive symptoms in the 1982-1984 study (CES-D score > or = 16). During follow-up, there were 465 incident cases of diabetes. Incidence of diabetes was 6.9/1000 person years among those with high depressive symptoms, 6.0/1000 person years among those with moderate symptoms, and 5.0/1000 person years among those with no symptoms. After adjusting for age, sex, and race, the relative hazard (RH) of diabetes among those with high depressive symptoms was 1.27 (95% CI: 0.93 to 1.73) compared to those without symptoms. Further adjustment for education and known diabetes risk factors (body mass index and physical activity) further attenuated the relationship (RH 1.11, 95% CI: 0.79 to 1.56).

CONCLUSIONS

There was no increased incidence of diabetes for those with high or moderate depressive symptoms compared to those with no depressive symptoms. These results do not support the etiologic relationship of depression predisposing individuals to diabetes.

Authors+Show Affiliations

Social and Scientific Systems, Inc., 8757 Georgia Avenue 12th Floor, Silver Spring, MD, USA. ssaydah@s-3.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study

Language

eng

PubMed ID

12789653

Citation

Saydah, Sharon H., et al. "Depressive Symptoms and the Risk of Type 2 Diabetes Mellitus in a US Sample." Diabetes/metabolism Research and Reviews, vol. 19, no. 3, 2003, pp. 202-8.
Saydah SH, Brancati FL, Golden SH, et al. Depressive symptoms and the risk of type 2 diabetes mellitus in a US sample. Diabetes Metab Res Rev. 2003;19(3):202-8.
Saydah, S. H., Brancati, F. L., Golden, S. H., Fradkin, J., & Harris, M. I. (2003). Depressive symptoms and the risk of type 2 diabetes mellitus in a US sample. Diabetes/metabolism Research and Reviews, 19(3), pp. 202-8.
Saydah SH, et al. Depressive Symptoms and the Risk of Type 2 Diabetes Mellitus in a US Sample. Diabetes Metab Res Rev. 2003;19(3):202-8. PubMed PMID: 12789653.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Depressive symptoms and the risk of type 2 diabetes mellitus in a US sample. AU - Saydah,Sharon H, AU - Brancati,Frederick L, AU - Golden,Sherita Hill, AU - Fradkin,Judith, AU - Harris,Maureen I, PY - 2003/6/6/pubmed PY - 2004/1/24/medline PY - 2003/6/6/entrez SP - 202 EP - 8 JF - Diabetes/metabolism research and reviews JO - Diabetes Metab. Res. Rev. VL - 19 IS - 3 N2 - OBJECTIVE: There is some evidence to suggest that individuals with depression are at an almost twofold increased risk of developing type 2 diabetes mellitus, but results are far from conclusive. Therefore, to determine if depressive symptoms increased the risk of type 2 diabetes, we conducted longitudinal analyses using data from the NHANES I Epidemiologic Follow-up Survey (NHEFS). RESEARCH DESIGN AND METHODS: Participants included individuals who were white or African-American, did not report previous diagnosis of diabetes, and who completed the Centers for Epidemiologic Studies Depression (CES-D) questionnaire in the 1982-1984 study (n = 8870). Participants were followed up for incident-diagnosed diabetes through 1992 (mean follow-up 9.0 years). RESULTS: There were 1444 (15.9%) participants with high depressive symptoms in the 1982-1984 study (CES-D score > or = 16). During follow-up, there were 465 incident cases of diabetes. Incidence of diabetes was 6.9/1000 person years among those with high depressive symptoms, 6.0/1000 person years among those with moderate symptoms, and 5.0/1000 person years among those with no symptoms. After adjusting for age, sex, and race, the relative hazard (RH) of diabetes among those with high depressive symptoms was 1.27 (95% CI: 0.93 to 1.73) compared to those without symptoms. Further adjustment for education and known diabetes risk factors (body mass index and physical activity) further attenuated the relationship (RH 1.11, 95% CI: 0.79 to 1.56). CONCLUSIONS: There was no increased incidence of diabetes for those with high or moderate depressive symptoms compared to those with no depressive symptoms. These results do not support the etiologic relationship of depression predisposing individuals to diabetes. SN - 1520-7552 UR - https://www.unboundmedicine.com/medline/citation/12789653/Depressive_symptoms_and_the_risk_of_type_2_diabetes_mellitus_in_a_US_sample_ L2 - https://doi.org/10.1002/dmrr.353 DB - PRIME DP - Unbound Medicine ER -