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Assessment of dysplastic dentin in osteogenesis imperfecta and dentinogenesis imperfecta.
Acta Odontol Scand. 2003 Apr; 61(2):72-80.AO

Abstract

Two semiquantitative scoring systems, Clinical Radiographic Score (CRS) and Dysplastic Dentin Score (DDS), were introduced for analyzing degree of dysplastic manifestations in dentin. The utility of both systems was demonstrated in a large material of teeth from patients with dentinogenesis imperfecta (DI) and osteogenesis imperfecta (OI). Twenty teeth from healthy controls, 81 teeth from 40 patients with OI, and 18 teeth with DI without OI (DI type II) were examined. The degree of dysplasia was correlated with type and form of OI and type of DI. The median DDS did not differ between DI associated with OI (DI type I) and DI type II. DDS in OI patients without clinical signs of DI was above that of control teeth. Both circumpulpal and mantle dentin showed increased DDS, although circumpulpal dentin was more severely affected. The median DDS was highest for the most severe type of non-lethal OI (type III). DDS increased significantly with form (severity) of OI. A significant association between DDS and CRS was found, although diagnosis of DI in less severe cases was not possible based on radiographic or clinical signs alone. Thus, the DDS system proved valuable when the CRS system based on radiographic/clinical manifestations failed, the most significant finding being subclinical histological manifestations of DI in patients with OI but without clinical or radiographic signs of DI. These subtle dysplastic changes are most likely an expression of genetic disturbances associated with OI and should not be diagnosed as DI, but rather be termed histologic manifestations of dysplastic dentin associated with OI.

Authors+Show Affiliations

Department of Pediatrics, Pediatric Endocrine Research Unit, B62, Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden. barbro.malmgren@telia.comNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12790503

Citation

Malmgren, Barbro, and Sven Lindskog. "Assessment of Dysplastic Dentin in Osteogenesis Imperfecta and Dentinogenesis Imperfecta." Acta Odontologica Scandinavica, vol. 61, no. 2, 2003, pp. 72-80.
Malmgren B, Lindskog S. Assessment of dysplastic dentin in osteogenesis imperfecta and dentinogenesis imperfecta. Acta Odontol Scand. 2003;61(2):72-80.
Malmgren, B., & Lindskog, S. (2003). Assessment of dysplastic dentin in osteogenesis imperfecta and dentinogenesis imperfecta. Acta Odontologica Scandinavica, 61(2), 72-80.
Malmgren B, Lindskog S. Assessment of Dysplastic Dentin in Osteogenesis Imperfecta and Dentinogenesis Imperfecta. Acta Odontol Scand. 2003;61(2):72-80. PubMed PMID: 12790503.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of dysplastic dentin in osteogenesis imperfecta and dentinogenesis imperfecta. AU - Malmgren,Barbro, AU - Lindskog,Sven, PY - 2003/6/7/pubmed PY - 2003/8/6/medline PY - 2003/6/7/entrez SP - 72 EP - 80 JF - Acta odontologica Scandinavica JO - Acta Odontol Scand VL - 61 IS - 2 N2 - Two semiquantitative scoring systems, Clinical Radiographic Score (CRS) and Dysplastic Dentin Score (DDS), were introduced for analyzing degree of dysplastic manifestations in dentin. The utility of both systems was demonstrated in a large material of teeth from patients with dentinogenesis imperfecta (DI) and osteogenesis imperfecta (OI). Twenty teeth from healthy controls, 81 teeth from 40 patients with OI, and 18 teeth with DI without OI (DI type II) were examined. The degree of dysplasia was correlated with type and form of OI and type of DI. The median DDS did not differ between DI associated with OI (DI type I) and DI type II. DDS in OI patients without clinical signs of DI was above that of control teeth. Both circumpulpal and mantle dentin showed increased DDS, although circumpulpal dentin was more severely affected. The median DDS was highest for the most severe type of non-lethal OI (type III). DDS increased significantly with form (severity) of OI. A significant association between DDS and CRS was found, although diagnosis of DI in less severe cases was not possible based on radiographic or clinical signs alone. Thus, the DDS system proved valuable when the CRS system based on radiographic/clinical manifestations failed, the most significant finding being subclinical histological manifestations of DI in patients with OI but without clinical or radiographic signs of DI. These subtle dysplastic changes are most likely an expression of genetic disturbances associated with OI and should not be diagnosed as DI, but rather be termed histologic manifestations of dysplastic dentin associated with OI. SN - 0001-6357 UR - https://www.unboundmedicine.com/medline/citation/12790503/Assessment_of_dysplastic_dentin_in_osteogenesis_imperfecta_and_dentinogenesis_imperfecta_ L2 - https://www.tandfonline.com/doi/full/10.1080/00016350310001398 DB - PRIME DP - Unbound Medicine ER -