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Dietary carotenoids and risk of coronary artery disease in women.

Abstract

BACKGROUND

Numerous studies have shown that higher intakes or higher blood concentrations of carotenes are associated with a lower risk of coronary artery disease (CAD). Given the null results in trials of beta-carotene supplementation, considerable attention has focused on the potential role of other dietary carotenoids in the prevention of CAD.

OBJECTIVE

Our objective was to prospectively examine the relation between dietary intakes of specific carotenoids and risk of CAD in women.

DESIGN

In 1984, 73 286 female nurses completed a semiquantitative food-frequency questionnaire that assessed their consumption of carotenoids and various other nutrients. The women were followed for 12 y for the development of incident CAD (nonfatal myocardial infarction and fatal CAD), and dietary information was updated in 1986, 1990, and 1994.

RESULTS

During 12 y of follow-up (803 590 person-years), we identified 998 incident cases of CAD. After adjustment for age, smoking, and other CAD risk factors, we observed modest but significant inverse associations between the highest quintiles of intake of beta-carotene and alpha-carotene and risk of CAD but no significant relation with intakes of lutein/zeaxanthin, lycopene, or beta-cryptoxanthin. For women in the highest compared with the respective lowest quintile of intake, the relative risks for beta-carotene and alpha-carotene were 0.74 (95% CI: 0.59, 0.93) and 0.80 (95% CI: 0.65, 0.99), respectively. The association between the specific carotenoids and CAD risk did not vary significantly by current smoking status.

CONCLUSION

Higher intakes of foods rich in alpha-carotene or beta-carotene are associated with a reduction in risk of CAD.

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  • Authors+Show Affiliations

    ,

    Children's Hospital, Department of Medicine, Boston, MA 02115, USA. stavroula.osganian@tch.harvard.edu

    , , , ,

    Source

    MeSH

    Adult
    Antioxidants
    Carotenoids
    Coronary Disease
    Diet
    Dose-Response Relationship, Drug
    Female
    Follow-Up Studies
    Humans
    Middle Aged
    Prospective Studies
    Risk
    beta Carotene

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    12791615

    Citation

    Osganian, Stavroula K., et al. "Dietary Carotenoids and Risk of Coronary Artery Disease in Women." The American Journal of Clinical Nutrition, vol. 77, no. 6, 2003, pp. 1390-9.
    Osganian SK, Stampfer MJ, Rimm E, et al. Dietary carotenoids and risk of coronary artery disease in women. Am J Clin Nutr. 2003;77(6):1390-9.
    Osganian, S. K., Stampfer, M. J., Rimm, E., Spiegelman, D., Manson, J. E., & Willett, W. C. (2003). Dietary carotenoids and risk of coronary artery disease in women. The American Journal of Clinical Nutrition, 77(6), pp. 1390-9.
    Osganian SK, et al. Dietary Carotenoids and Risk of Coronary Artery Disease in Women. Am J Clin Nutr. 2003;77(6):1390-9. PubMed PMID: 12791615.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary carotenoids and risk of coronary artery disease in women. AU - Osganian,Stavroula K, AU - Stampfer,Meir J, AU - Rimm,Eric, AU - Spiegelman,Donna, AU - Manson,JoAnn E, AU - Willett,Walter C, PY - 2003/6/7/pubmed PY - 2003/7/4/medline PY - 2003/6/7/entrez SP - 1390 EP - 9 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 77 IS - 6 N2 - BACKGROUND: Numerous studies have shown that higher intakes or higher blood concentrations of carotenes are associated with a lower risk of coronary artery disease (CAD). Given the null results in trials of beta-carotene supplementation, considerable attention has focused on the potential role of other dietary carotenoids in the prevention of CAD. OBJECTIVE: Our objective was to prospectively examine the relation between dietary intakes of specific carotenoids and risk of CAD in women. DESIGN: In 1984, 73 286 female nurses completed a semiquantitative food-frequency questionnaire that assessed their consumption of carotenoids and various other nutrients. The women were followed for 12 y for the development of incident CAD (nonfatal myocardial infarction and fatal CAD), and dietary information was updated in 1986, 1990, and 1994. RESULTS: During 12 y of follow-up (803 590 person-years), we identified 998 incident cases of CAD. After adjustment for age, smoking, and other CAD risk factors, we observed modest but significant inverse associations between the highest quintiles of intake of beta-carotene and alpha-carotene and risk of CAD but no significant relation with intakes of lutein/zeaxanthin, lycopene, or beta-cryptoxanthin. For women in the highest compared with the respective lowest quintile of intake, the relative risks for beta-carotene and alpha-carotene were 0.74 (95% CI: 0.59, 0.93) and 0.80 (95% CI: 0.65, 0.99), respectively. The association between the specific carotenoids and CAD risk did not vary significantly by current smoking status. CONCLUSION: Higher intakes of foods rich in alpha-carotene or beta-carotene are associated with a reduction in risk of CAD. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/12791615/full_citation L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/77.6.1390 DB - PRIME DP - Unbound Medicine ER -