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Isoflavones and cognitive function in older women: the SOy and Postmenopausal Health In Aging (SOPHIA) Study.
Menopause 2003 May-Jun; 10(3):196-202M

Abstract

OBJECTIVE

This study examines the effects of a dietary supplement of isoflavones on cognitive function in postmenopausal women.

DESIGN

Participants for this 6-month, double-blind, randomized, placebo-controlled clinical trial were women who were in good health, were postmenopausal at least 2 years, and were not using estrogen replacement therapy. Between July 24, 2000, and October 31, 2000, 56 women aged 55 to 74 years were randomized; 2 in the placebo group and 1 in the active treatment group did not complete the 6-month evaluation, and none withdrew because of adverse effects. Women randomized to active treatment (n = 27) took two pills per day, each containing 55 mg of soy-extracted isoflavones (110 mg total isoflavones per day; Healthy Woman: Soy Menopause Supplement, Personal Products Company, McNeil-PPC Inc., Skillman, NJ, USA). Women assigned to placebo (n = 26) took two identical-appearing pills per day containing inert ingredients. Cognitive function tests administered at baseline and follow-up included the following: Trails A and B, category fluency, and logical memory and recall (a paragraph recall test assessing immediate and delayed verbal memory).

RESULTS

At baseline, all women were cognitively intact; there were no significant differences by treatment assignment in age, education, depressed mood, or cognitive function (all P values > 0.10). Compliance was 98% and 97%, respectively, in the placebo and treatment groups; all women took at least 85% of their pills. The women in the treatment group did consistently better, both as compared with their own baseline scores and as compared with the placebo group responses at 6 months. Comparisons of percentage change in cognitive function between baseline and follow-up showed greater improvement in category fluency for women on active treatment as compared with the case of those on placebo (P = 0.02) and showed (nonsignificantly) greater improvement on the two other tests of verbal memory and Trails B.

CONCLUSION

These results suggest that isoflavone supplementation has a favorable effect on cognitive function, particularly verbal memory, in postmenopausal women.

Authors+Show Affiliations

University of California, San Diego, School of Medicine, Department of Family and Preventive Medicine, Division of Epidemiology, La Jolla 92093, USA. dsilverstein@ucsd.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12792289

Citation

Kritz-Silverstein, Donna, et al. "Isoflavones and Cognitive Function in Older Women: the SOy and Postmenopausal Health in Aging (SOPHIA) Study." Menopause (New York, N.Y.), vol. 10, no. 3, 2003, pp. 196-202.
Kritz-Silverstein D, Von Mühlen D, Barrett-Connor E, et al. Isoflavones and cognitive function in older women: the SOy and Postmenopausal Health In Aging (SOPHIA) Study. Menopause. 2003;10(3):196-202.
Kritz-Silverstein, D., Von Mühlen, D., Barrett-Connor, E., & Bressel, M. A. (2003). Isoflavones and cognitive function in older women: the SOy and Postmenopausal Health In Aging (SOPHIA) Study. Menopause (New York, N.Y.), 10(3), pp. 196-202.
Kritz-Silverstein D, et al. Isoflavones and Cognitive Function in Older Women: the SOy and Postmenopausal Health in Aging (SOPHIA) Study. Menopause. 2003;10(3):196-202. PubMed PMID: 12792289.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isoflavones and cognitive function in older women: the SOy and Postmenopausal Health In Aging (SOPHIA) Study. AU - Kritz-Silverstein,Donna, AU - Von Mühlen,Denise, AU - Barrett-Connor,Elizabeth, AU - Bressel,Mathias A B, PY - 2003/6/7/pubmed PY - 2003/9/17/medline PY - 2003/6/7/entrez SP - 196 EP - 202 JF - Menopause (New York, N.Y.) JO - Menopause VL - 10 IS - 3 N2 - OBJECTIVE: This study examines the effects of a dietary supplement of isoflavones on cognitive function in postmenopausal women. DESIGN: Participants for this 6-month, double-blind, randomized, placebo-controlled clinical trial were women who were in good health, were postmenopausal at least 2 years, and were not using estrogen replacement therapy. Between July 24, 2000, and October 31, 2000, 56 women aged 55 to 74 years were randomized; 2 in the placebo group and 1 in the active treatment group did not complete the 6-month evaluation, and none withdrew because of adverse effects. Women randomized to active treatment (n = 27) took two pills per day, each containing 55 mg of soy-extracted isoflavones (110 mg total isoflavones per day; Healthy Woman: Soy Menopause Supplement, Personal Products Company, McNeil-PPC Inc., Skillman, NJ, USA). Women assigned to placebo (n = 26) took two identical-appearing pills per day containing inert ingredients. Cognitive function tests administered at baseline and follow-up included the following: Trails A and B, category fluency, and logical memory and recall (a paragraph recall test assessing immediate and delayed verbal memory). RESULTS: At baseline, all women were cognitively intact; there were no significant differences by treatment assignment in age, education, depressed mood, or cognitive function (all P values > 0.10). Compliance was 98% and 97%, respectively, in the placebo and treatment groups; all women took at least 85% of their pills. The women in the treatment group did consistently better, both as compared with their own baseline scores and as compared with the placebo group responses at 6 months. Comparisons of percentage change in cognitive function between baseline and follow-up showed greater improvement in category fluency for women on active treatment as compared with the case of those on placebo (P = 0.02) and showed (nonsignificantly) greater improvement on the two other tests of verbal memory and Trails B. CONCLUSION: These results suggest that isoflavone supplementation has a favorable effect on cognitive function, particularly verbal memory, in postmenopausal women. SN - 1072-3714 UR - https://www.unboundmedicine.com/medline/citation/12792289/Isoflavones_and_cognitive_function_in_older_women:_the_SOy_and_Postmenopausal_Health_In_Aging__SOPHIA__Study_ L2 - http://Insights.ovid.com/pubmed?pmid=12792289 DB - PRIME DP - Unbound Medicine ER -