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Isoflavones and cognitive function in older women: the SOy and Postmenopausal Health In Aging (SOPHIA) Study.

Abstract

OBJECTIVE

This study examines the effects of a dietary supplement of isoflavones on cognitive function in postmenopausal women.

DESIGN

Participants for this 6-month, double-blind, randomized, placebo-controlled clinical trial were women who were in good health, were postmenopausal at least 2 years, and were not using estrogen replacement therapy. Between July 24, 2000, and October 31, 2000, 56 women aged 55 to 74 years were randomized; 2 in the placebo group and 1 in the active treatment group did not complete the 6-month evaluation, and none withdrew because of adverse effects. Women randomized to active treatment (n = 27) took two pills per day, each containing 55 mg of soy-extracted isoflavones (110 mg total isoflavones per day; Healthy Woman: Soy Menopause Supplement, Personal Products Company, McNeil-PPC Inc., Skillman, NJ, USA). Women assigned to placebo (n = 26) took two identical-appearing pills per day containing inert ingredients. Cognitive function tests administered at baseline and follow-up included the following: Trails A and B, category fluency, and logical memory and recall (a paragraph recall test assessing immediate and delayed verbal memory).

RESULTS

At baseline, all women were cognitively intact; there were no significant differences by treatment assignment in age, education, depressed mood, or cognitive function (all P values > 0.10). Compliance was 98% and 97%, respectively, in the placebo and treatment groups; all women took at least 85% of their pills. The women in the treatment group did consistently better, both as compared with their own baseline scores and as compared with the placebo group responses at 6 months. Comparisons of percentage change in cognitive function between baseline and follow-up showed greater improvement in category fluency for women on active treatment as compared with the case of those on placebo (P = 0.02) and showed (nonsignificantly) greater improvement on the two other tests of verbal memory and Trails B.

CONCLUSION

These results suggest that isoflavone supplementation has a favorable effect on cognitive function, particularly verbal memory, in postmenopausal women.

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  • Authors+Show Affiliations

    ,

    University of California, San Diego, School of Medicine, Department of Family and Preventive Medicine, Division of Epidemiology, La Jolla 92093, USA. dsilverstein@ucsd.edu

    , ,

    Source

    MeSH

    Age Factors
    Aged
    Cognition
    Dietary Supplements
    Double-Blind Method
    Estrogens, Non-Steroidal
    Female
    Humans
    Isoflavones
    Memory
    Mental Recall
    Middle Aged
    Phytotherapy
    Plant Extracts
    Postmenopause
    Psychiatric Status Rating Scales
    Soybeans
    Verbal Learning

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    12792289

    Citation

    Kritz-Silverstein, Donna, et al. "Isoflavones and Cognitive Function in Older Women: the SOy and Postmenopausal Health in Aging (SOPHIA) Study." Menopause (New York, N.Y.), vol. 10, no. 3, 2003, pp. 196-202.
    Kritz-Silverstein D, Von Mühlen D, Barrett-Connor E, et al. Isoflavones and cognitive function in older women: the SOy and Postmenopausal Health In Aging (SOPHIA) Study. Menopause. 2003;10(3):196-202.
    Kritz-Silverstein, D., Von Mühlen, D., Barrett-Connor, E., & Bressel, M. A. (2003). Isoflavones and cognitive function in older women: the SOy and Postmenopausal Health In Aging (SOPHIA) Study. Menopause (New York, N.Y.), 10(3), pp. 196-202.
    Kritz-Silverstein D, et al. Isoflavones and Cognitive Function in Older Women: the SOy and Postmenopausal Health in Aging (SOPHIA) Study. Menopause. 2003;10(3):196-202. PubMed PMID: 12792289.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Isoflavones and cognitive function in older women: the SOy and Postmenopausal Health In Aging (SOPHIA) Study. AU - Kritz-Silverstein,Donna, AU - Von Mühlen,Denise, AU - Barrett-Connor,Elizabeth, AU - Bressel,Mathias A B, PY - 2003/6/7/pubmed PY - 2003/9/17/medline PY - 2003/6/7/entrez SP - 196 EP - 202 JF - Menopause (New York, N.Y.) JO - Menopause VL - 10 IS - 3 N2 - OBJECTIVE: This study examines the effects of a dietary supplement of isoflavones on cognitive function in postmenopausal women. DESIGN: Participants for this 6-month, double-blind, randomized, placebo-controlled clinical trial were women who were in good health, were postmenopausal at least 2 years, and were not using estrogen replacement therapy. Between July 24, 2000, and October 31, 2000, 56 women aged 55 to 74 years were randomized; 2 in the placebo group and 1 in the active treatment group did not complete the 6-month evaluation, and none withdrew because of adverse effects. Women randomized to active treatment (n = 27) took two pills per day, each containing 55 mg of soy-extracted isoflavones (110 mg total isoflavones per day; Healthy Woman: Soy Menopause Supplement, Personal Products Company, McNeil-PPC Inc., Skillman, NJ, USA). Women assigned to placebo (n = 26) took two identical-appearing pills per day containing inert ingredients. Cognitive function tests administered at baseline and follow-up included the following: Trails A and B, category fluency, and logical memory and recall (a paragraph recall test assessing immediate and delayed verbal memory). RESULTS: At baseline, all women were cognitively intact; there were no significant differences by treatment assignment in age, education, depressed mood, or cognitive function (all P values > 0.10). Compliance was 98% and 97%, respectively, in the placebo and treatment groups; all women took at least 85% of their pills. The women in the treatment group did consistently better, both as compared with their own baseline scores and as compared with the placebo group responses at 6 months. Comparisons of percentage change in cognitive function between baseline and follow-up showed greater improvement in category fluency for women on active treatment as compared with the case of those on placebo (P = 0.02) and showed (nonsignificantly) greater improvement on the two other tests of verbal memory and Trails B. CONCLUSION: These results suggest that isoflavone supplementation has a favorable effect on cognitive function, particularly verbal memory, in postmenopausal women. SN - 1072-3714 UR - https://www.unboundmedicine.com/medline/citation/12792289/Isoflavones_and_cognitive_function_in_older_women:_the_SOy_and_Postmenopausal_Health_In_Aging__SOPHIA__Study_ L2 - http://Insights.ovid.com/pubmed?pmid=12792289 DB - PRIME DP - Unbound Medicine ER -