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Tomato consumption increases lycopene isomer concentrations in breast milk and plasma of lactating women.
J Am Diet Assoc. 2002 Sep; 102(9):1257-62.JA

Abstract

OBJECTIVE

To compare plasma and milk lycopene concentrations and the changes in lycopene isomer patterns in lactating women before and after a 3-day dietary intervention with fresh or processed tomato products.

DESIGN

Randomized prospective trial.

SUBJECTS

24 lactating women, 4 to 12 weeks postpartum, aged 22 to 39 years.

INTERVENTION

Subjects initially consumed a low-lycopene diet for 7 days (washout period) and then were randomly assigned to one of 3 dietary groups (n=8 per group) without any other sources of lycopene: control (low-lycopene), fresh tomatoes, or processed tomato sauce. Subjects in each of the tomato groups consumed approximately 50 mg total lycopene over 3 days.

OUTCOME MEASURES

Before and after dietary intervention, plasma and breast milk samples were obtained for high-performance liquid chromotography analysis of lycopene and its geometric isomers (all-trans, 5-cis, all other cis, and total lycopene).

STATISTICAL ANALYSIS

Descriptive statistics, analysis of variance to test for differences among intervention groups, and Spearman's correlation coefficients to test for blood-milk relationships.

RESULTS

Plasma total lycopene and lycopene isomer concentrations increased in the fresh and processed tomato group but not in the low-lycopene control group during the study. Milk total and cis- and trans-lycopene concentrations (unadjusted for fat) increased in the processed tomato group but did not change in the fresh tomato group. In the control group, milk total and trans-lycopene decreased. Milk total lycopene concentrations were not significantly different from baseline in any group when adjusted for fat content of milk.

APPLICATIONS

The results of this study indicate that consumption of a "standard size portion" of tomato products increases plasma and milk lycopene concentrations in lactating women and, therefore, could increase the lycopene status of nursing infants. For dietary recommendations during lactation, the results suggest that consumption of tomato sauce increases milk lycopene concentrations more effectively than consumption of fresh tomatoes.

Authors+Show Affiliations

Department of Food Science and Technology, The Ohio State University, 2121 Fuffe Court, Columbus, OH 43210, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

12792623

Citation

Alien, Charlotte M., et al. "Tomato Consumption Increases Lycopene Isomer Concentrations in Breast Milk and Plasma of Lactating Women." Journal of the American Dietetic Association, vol. 102, no. 9, 2002, pp. 1257-62.
Alien CM, Smith AM, Clinton SK, et al. Tomato consumption increases lycopene isomer concentrations in breast milk and plasma of lactating women. J Am Diet Assoc. 2002;102(9):1257-62.
Alien, C. M., Smith, A. M., Clinton, S. K., & Schwartz, S. J. (2002). Tomato consumption increases lycopene isomer concentrations in breast milk and plasma of lactating women. Journal of the American Dietetic Association, 102(9), 1257-62.
Alien CM, et al. Tomato Consumption Increases Lycopene Isomer Concentrations in Breast Milk and Plasma of Lactating Women. J Am Diet Assoc. 2002;102(9):1257-62. PubMed PMID: 12792623.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tomato consumption increases lycopene isomer concentrations in breast milk and plasma of lactating women. AU - Alien,Charlotte M, AU - Smith,Anne M, AU - Clinton,Steven K, AU - Schwartz,Steven J, PY - 2003/6/7/pubmed PY - 2004/9/24/medline PY - 2003/6/7/entrez SP - 1257 EP - 62 JF - Journal of the American Dietetic Association JO - J Am Diet Assoc VL - 102 IS - 9 N2 - OBJECTIVE: To compare plasma and milk lycopene concentrations and the changes in lycopene isomer patterns in lactating women before and after a 3-day dietary intervention with fresh or processed tomato products. DESIGN: Randomized prospective trial. SUBJECTS: 24 lactating women, 4 to 12 weeks postpartum, aged 22 to 39 years. INTERVENTION: Subjects initially consumed a low-lycopene diet for 7 days (washout period) and then were randomly assigned to one of 3 dietary groups (n=8 per group) without any other sources of lycopene: control (low-lycopene), fresh tomatoes, or processed tomato sauce. Subjects in each of the tomato groups consumed approximately 50 mg total lycopene over 3 days. OUTCOME MEASURES: Before and after dietary intervention, plasma and breast milk samples were obtained for high-performance liquid chromotography analysis of lycopene and its geometric isomers (all-trans, 5-cis, all other cis, and total lycopene). STATISTICAL ANALYSIS: Descriptive statistics, analysis of variance to test for differences among intervention groups, and Spearman's correlation coefficients to test for blood-milk relationships. RESULTS: Plasma total lycopene and lycopene isomer concentrations increased in the fresh and processed tomato group but not in the low-lycopene control group during the study. Milk total and cis- and trans-lycopene concentrations (unadjusted for fat) increased in the processed tomato group but did not change in the fresh tomato group. In the control group, milk total and trans-lycopene decreased. Milk total lycopene concentrations were not significantly different from baseline in any group when adjusted for fat content of milk. APPLICATIONS: The results of this study indicate that consumption of a "standard size portion" of tomato products increases plasma and milk lycopene concentrations in lactating women and, therefore, could increase the lycopene status of nursing infants. For dietary recommendations during lactation, the results suggest that consumption of tomato sauce increases milk lycopene concentrations more effectively than consumption of fresh tomatoes. SN - 0002-8223 UR - https://www.unboundmedicine.com/medline/citation/12792623/Tomato_consumption_increases_lycopene_isomer_concentrations_in_breast_milk_and_plasma_of_lactating_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002822302902786 DB - PRIME DP - Unbound Medicine ER -