Tags

Type your tag names separated by a space and hit enter

Analysis of risk factors for hepatocellular carcinoma that is negative for hepatitis B surface antigen (HBsAg).
Intern Med 2003; 42(5):389-93IM

Abstract

OBJECTIVE

To clarify risk factors for hepatocellular carcinoma (HCC) other than hepatitis B surface antigen (HBsAg).

PATIENTS AND METHODS

We investigated serum HBV-DNA and other factors in 146 patients with liver cirrhosis (LC) or HCC who were HBsAg negative. We analyzed the clinical background of the patients, status of hepatitis B (HBV) viral markers and platelet count as well as the presence of an HBV-DNA fragment by PCR and elucidated risk factors for HCC generation using a logistic regression model.

RESULTS

Among ten factors, we determined that four represented a significant risk for HBsAg negative HCC: male gender, total alcohol consumption, total cigarettes smoked, and the presence of an HBV-DNA fragment. Multivariate analysis showed that among the four factors, the HBV-DNA fragment was an independent factor associated with HCC.

CONCLUSION

The presence of an HBV-DNA fragment irrespective of the status of antibodies to either HBsAg (anti-HBs) or hepatitis B core antigen (anti-HBc) is a pivotal factor associated with the development of HCC.

Authors+Show Affiliations

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University Aoto Hospital, Tokyo.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12793707

Citation

Shimada, Seika, et al. "Analysis of Risk Factors for Hepatocellular Carcinoma That Is Negative for Hepatitis B Surface Antigen (HBsAg)." Internal Medicine (Tokyo, Japan), vol. 42, no. 5, 2003, pp. 389-93.
Shimada S, Aizawa R, Abe H, et al. Analysis of risk factors for hepatocellular carcinoma that is negative for hepatitis B surface antigen (HBsAg). Intern Med. 2003;42(5):389-93.
Shimada, S., Aizawa, R., Abe, H., Suto, S., Miyakawa, Y., & Aizawa, Y. (2003). Analysis of risk factors for hepatocellular carcinoma that is negative for hepatitis B surface antigen (HBsAg). Internal Medicine (Tokyo, Japan), 42(5), pp. 389-93.
Shimada S, et al. Analysis of Risk Factors for Hepatocellular Carcinoma That Is Negative for Hepatitis B Surface Antigen (HBsAg). Intern Med. 2003;42(5):389-93. PubMed PMID: 12793707.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of risk factors for hepatocellular carcinoma that is negative for hepatitis B surface antigen (HBsAg). AU - Shimada,Seika, AU - Aizawa,Ryoichi, AU - Abe,Hiroshi, AU - Suto,Satoshi, AU - Miyakawa,Yoshinari, AU - Aizawa,Yoshio, PY - 2003/6/10/pubmed PY - 2003/10/22/medline PY - 2003/6/10/entrez SP - 389 EP - 93 JF - Internal medicine (Tokyo, Japan) JO - Intern. Med. VL - 42 IS - 5 N2 - OBJECTIVE: To clarify risk factors for hepatocellular carcinoma (HCC) other than hepatitis B surface antigen (HBsAg). PATIENTS AND METHODS: We investigated serum HBV-DNA and other factors in 146 patients with liver cirrhosis (LC) or HCC who were HBsAg negative. We analyzed the clinical background of the patients, status of hepatitis B (HBV) viral markers and platelet count as well as the presence of an HBV-DNA fragment by PCR and elucidated risk factors for HCC generation using a logistic regression model. RESULTS: Among ten factors, we determined that four represented a significant risk for HBsAg negative HCC: male gender, total alcohol consumption, total cigarettes smoked, and the presence of an HBV-DNA fragment. Multivariate analysis showed that among the four factors, the HBV-DNA fragment was an independent factor associated with HCC. CONCLUSION: The presence of an HBV-DNA fragment irrespective of the status of antibodies to either HBsAg (anti-HBs) or hepatitis B core antigen (anti-HBc) is a pivotal factor associated with the development of HCC. SN - 0918-2918 UR - https://www.unboundmedicine.com/medline/citation/12793707/Analysis_of_risk_factors_for_hepatocellular_carcinoma_that_is_negative_for_hepatitis_B_surface_antigen__HBsAg__ L2 - https://joi.jlc.jst.go.jp/JST.Journalarchive/internalmedicine1992/42.389?from=PubMed DB - PRIME DP - Unbound Medicine ER -