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Sjogren's syndrome and drug reaction to practalol.
N Z Med J 1975; 82(548):199-201NZ

Abstract

A case is reported of a patient who developed exfoliative dermatitis while being treated with practalol for angina pectoris. The patient also had trigeminal neuropathy, renal impairment and keratoconjunctivitis sicca. The antinuclear factor was diffusely positive but other antibodies were negative. At post mortem the patient was found to have acute pancreatitis, and peritonitis. It is postulated that the patient has antecedent Sjogren's syndrome and on introduction of practalol therapy developed a drug reaction with a generalised exfoliative dermatitis and exacerbation of keratoconjunctivitis sicca leading to bilateral corneal ulceration. The association of similar conditions in patients receiving practalol therapy is reviewed.

Authors

No affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

127954

Citation

Dunn, P J.. "Sjogren's Syndrome and Drug Reaction to Practalol." The New Zealand Medical Journal, vol. 82, no. 548, 1975, pp. 199-201.
Dunn PJ. Sjogren's syndrome and drug reaction to practalol. N Z Med J. 1975;82(548):199-201.
Dunn, P. J. (1975). Sjogren's syndrome and drug reaction to practalol. The New Zealand Medical Journal, 82(548), pp. 199-201.
Dunn PJ. Sjogren's Syndrome and Drug Reaction to Practalol. N Z Med J. 1975 Sep 24;82(548):199-201. PubMed PMID: 127954.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sjogren's syndrome and drug reaction to practalol. A1 - Dunn,P J, PY - 1975/9/24/pubmed PY - 1975/9/24/medline PY - 1975/9/24/entrez SP - 199 EP - 201 JF - The New Zealand medical journal JO - N. Z. Med. J. VL - 82 IS - 548 N2 - A case is reported of a patient who developed exfoliative dermatitis while being treated with practalol for angina pectoris. The patient also had trigeminal neuropathy, renal impairment and keratoconjunctivitis sicca. The antinuclear factor was diffusely positive but other antibodies were negative. At post mortem the patient was found to have acute pancreatitis, and peritonitis. It is postulated that the patient has antecedent Sjogren's syndrome and on introduction of practalol therapy developed a drug reaction with a generalised exfoliative dermatitis and exacerbation of keratoconjunctivitis sicca leading to bilateral corneal ulceration. The association of similar conditions in patients receiving practalol therapy is reviewed. SN - 0028-8446 UR - https://www.unboundmedicine.com/medline/citation/127954/Sjogren's_syndrome_and_drug_reaction_to_practalol_ L2 - https://medlineplus.gov/sjogrenssyndrome.html DB - PRIME DP - Unbound Medicine ER -