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Comparison of gastric histology among Swedish and Japanese patients with peptic ulcer and Helicobacter pylori infection.
Scand J Gastroenterol. 2003 May; 38(5):491-7.SJ

Abstract

BACKGROUND

The natural course of Helicobacter pylori gastritis may vary between different ethnic groups. Gastric histopathology and the occurrence of H. pylori organisms in the stomach were investigated in healed duodenal (DU) and gastric (GU) ulcer patients recruited in Sweden (S) and Japan (J) in an identical trial.

METHODS

In 203 patients (JGU = 39, JDU = 55, SDU = 109), various morphological gastritis variables and H. pylori were assessed from biopsy specimens obtained using a specific sampling protocol and interpreted according to guidelines of the updated Sydney grading system.

RESULTS

The ratio of GU:DU was observed to be very different between the recruited Japanese (39:55) and Swedish (0:109) patients. A comparison of data from SDU and JDU showed that the prevalence of H. pylori infection and the antral predominant gastritis demonstrated by both SDU and JDU were essentially identical. A comparison of data from JDU and JGU demonstrated a greater prevalence of H. pylori infection in the antrum, but not corpus, of JDU compared to JGU patients. The prevalence of atrophy and intestinal metaplasia was higher in both the antrum and corpus of JGU compared to JDU in all patients.

CONCLUSIONS

The site specified biopsy methodology and standardized interpretation criteria utilized in this study clearly show that the histotopographic profile of Swedish and Japanese DU patients is essentially the same.

Authors+Show Affiliations

Dept. of Gastroenterology, Jichi Medical School, Yakushiji, Tochigi-ken, Japan. kimuken-go@sannet.ne.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

12795458

Citation

Kimura, K, et al. "Comparison of Gastric Histology Among Swedish and Japanese Patients With Peptic Ulcer and Helicobacter Pylori Infection." Scandinavian Journal of Gastroenterology, vol. 38, no. 5, 2003, pp. 491-7.
Kimura K, Sipponen P, Unge P, et al. Comparison of gastric histology among Swedish and Japanese patients with peptic ulcer and Helicobacter pylori infection. Scand J Gastroenterol. 2003;38(5):491-7.
Kimura, K., Sipponen, P., Unge, P., Ekström, P., Satoh, K., Hellblom, M., Ohlin, B., Stubberöd, A., Kihira, K., Yube, T., & Yoshida, Y. (2003). Comparison of gastric histology among Swedish and Japanese patients with peptic ulcer and Helicobacter pylori infection. Scandinavian Journal of Gastroenterology, 38(5), 491-7.
Kimura K, et al. Comparison of Gastric Histology Among Swedish and Japanese Patients With Peptic Ulcer and Helicobacter Pylori Infection. Scand J Gastroenterol. 2003;38(5):491-7. PubMed PMID: 12795458.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of gastric histology among Swedish and Japanese patients with peptic ulcer and Helicobacter pylori infection. AU - Kimura,K, AU - Sipponen,P, AU - Unge,P, AU - Ekström,P, AU - Satoh,K, AU - Hellblom,M, AU - Ohlin,B, AU - Stubberöd,A, AU - Kihira,K, AU - Yube,T, AU - Yoshida,Y, PY - 2003/6/11/pubmed PY - 2003/10/22/medline PY - 2003/6/11/entrez SP - 491 EP - 7 JF - Scandinavian journal of gastroenterology JO - Scand. J. Gastroenterol. VL - 38 IS - 5 N2 - BACKGROUND: The natural course of Helicobacter pylori gastritis may vary between different ethnic groups. Gastric histopathology and the occurrence of H. pylori organisms in the stomach were investigated in healed duodenal (DU) and gastric (GU) ulcer patients recruited in Sweden (S) and Japan (J) in an identical trial. METHODS: In 203 patients (JGU = 39, JDU = 55, SDU = 109), various morphological gastritis variables and H. pylori were assessed from biopsy specimens obtained using a specific sampling protocol and interpreted according to guidelines of the updated Sydney grading system. RESULTS: The ratio of GU:DU was observed to be very different between the recruited Japanese (39:55) and Swedish (0:109) patients. A comparison of data from SDU and JDU showed that the prevalence of H. pylori infection and the antral predominant gastritis demonstrated by both SDU and JDU were essentially identical. A comparison of data from JDU and JGU demonstrated a greater prevalence of H. pylori infection in the antrum, but not corpus, of JDU compared to JGU patients. The prevalence of atrophy and intestinal metaplasia was higher in both the antrum and corpus of JGU compared to JDU in all patients. CONCLUSIONS: The site specified biopsy methodology and standardized interpretation criteria utilized in this study clearly show that the histotopographic profile of Swedish and Japanese DU patients is essentially the same. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/12795458/Comparison_of_gastric_histology_among_Swedish_and_Japanese_patients_with_peptic_ulcer_and_Helicobacter_pylori_infection_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=12795458.ui DB - PRIME DP - Unbound Medicine ER -