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Alcohol drinking patterns and risk of type 2 diabetes mellitus among younger women.

Abstract

OBJECTIVE

To examine the relationship between alcohol consumption and the incidence of type 2 diabetes mellitus among relatively young and middle-aged women.

METHODS

In a prospective study, 109 690 women, aged 25 to 42 years, without a history of coronary heart disease, stroke, cancer, or diabetes mellitus completed a detailed lifestyle and medical history questionnaire in 1989. During 10 years of follow-up, we documented 935 incident cases of type 2 diabetes mellitus.

RESULTS

We found a nonlinear relationship between alcohol consumption and risk of type 2 diabetes mellitus after adjustment for multiple confounders, including body mass index, smoking, physical activity, and family history of diabetes mellitus (quadratic trend P =.003). Compared with lifelong abstainers, the adjusted relative risks (95% confidence intervals) were 0.80 (0.66-0.96) for those consuming 0.1 to 4.9 g/d, 0.67 (0.50-0.89) for those consuming 5.0 to 14.9 g/d, 0.42 (0.20-0.90) for those consuming 15.0 to 29.9 g/d, and 0.78 (0.34-1.78) for those consuming 30.0 g/d or more. Further adjustment for dietary factors, including glycemic load, trans-fatty acid, polyunsaturated fat, and total fiber intake, did not appreciably alter these findings. The inverse association with light to moderate drinking was most apparent in women who reported wine or beer drinking. Women who reported 30.0 g/d or more of liquor intake showed a significantly increased risk of diabetes mellitus compared with those who did not report liquor intake (adjusted relative risk, 2.50; 95% confidence interval, 1.00-6.23).

CONCLUSION

Light to moderate alcoholic beverage consumption may be associated with a lower risk of type 2 diabetes mellitus among women aged 25 to 42 years, although this benefit may not persist at higher levels.

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  • Authors+Show Affiliations

    ,

    Department of Nutrition, Harvard School of Public Health, Boston, Mass., USA. goya@pcps.ucl.ac.uk

    , , ,

    Source

    Archives of internal medicine 163:11 2003 Jun 09 pg 1329-36

    MeSH

    Adult
    Alcohol Drinking
    Body Mass Index
    Cohort Studies
    Diabetes Mellitus, Type 2
    Diet
    Exercise
    Family Health
    Female
    Humans
    Incidence
    Longitudinal Studies
    Prospective Studies
    Risk Factors
    Smoking
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    12796069

    Citation

    Wannamethee, S Goya, et al. "Alcohol Drinking Patterns and Risk of Type 2 Diabetes Mellitus Among Younger Women." Archives of Internal Medicine, vol. 163, no. 11, 2003, pp. 1329-36.
    Wannamethee SG, Camargo CA, Manson JE, et al. Alcohol drinking patterns and risk of type 2 diabetes mellitus among younger women. Arch Intern Med. 2003;163(11):1329-36.
    Wannamethee, S. G., Camargo, C. A., Manson, J. E., Willett, W. C., & Rimm, E. B. (2003). Alcohol drinking patterns and risk of type 2 diabetes mellitus among younger women. Archives of Internal Medicine, 163(11), pp. 1329-36.
    Wannamethee SG, et al. Alcohol Drinking Patterns and Risk of Type 2 Diabetes Mellitus Among Younger Women. Arch Intern Med. 2003 Jun 9;163(11):1329-36. PubMed PMID: 12796069.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Alcohol drinking patterns and risk of type 2 diabetes mellitus among younger women. AU - Wannamethee,S Goya, AU - Camargo,Carlos A,Jr AU - Manson,JoAnn E, AU - Willett,Walter C, AU - Rimm,Eric B, PY - 2003/6/11/pubmed PY - 2003/6/27/medline PY - 2003/6/11/entrez SP - 1329 EP - 36 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 163 IS - 11 N2 - OBJECTIVE: To examine the relationship between alcohol consumption and the incidence of type 2 diabetes mellitus among relatively young and middle-aged women. METHODS: In a prospective study, 109 690 women, aged 25 to 42 years, without a history of coronary heart disease, stroke, cancer, or diabetes mellitus completed a detailed lifestyle and medical history questionnaire in 1989. During 10 years of follow-up, we documented 935 incident cases of type 2 diabetes mellitus. RESULTS: We found a nonlinear relationship between alcohol consumption and risk of type 2 diabetes mellitus after adjustment for multiple confounders, including body mass index, smoking, physical activity, and family history of diabetes mellitus (quadratic trend P =.003). Compared with lifelong abstainers, the adjusted relative risks (95% confidence intervals) were 0.80 (0.66-0.96) for those consuming 0.1 to 4.9 g/d, 0.67 (0.50-0.89) for those consuming 5.0 to 14.9 g/d, 0.42 (0.20-0.90) for those consuming 15.0 to 29.9 g/d, and 0.78 (0.34-1.78) for those consuming 30.0 g/d or more. Further adjustment for dietary factors, including glycemic load, trans-fatty acid, polyunsaturated fat, and total fiber intake, did not appreciably alter these findings. The inverse association with light to moderate drinking was most apparent in women who reported wine or beer drinking. Women who reported 30.0 g/d or more of liquor intake showed a significantly increased risk of diabetes mellitus compared with those who did not report liquor intake (adjusted relative risk, 2.50; 95% confidence interval, 1.00-6.23). CONCLUSION: Light to moderate alcoholic beverage consumption may be associated with a lower risk of type 2 diabetes mellitus among women aged 25 to 42 years, although this benefit may not persist at higher levels. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/12796069/Alcohol_drinking_patterns_and_risk_of_type_2_diabetes_mellitus_among_younger_women_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/163/pg/1329 DB - PRIME DP - Unbound Medicine ER -