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Folate, vitamin B12, homocysteine, and the MTHFR 677C->T polymorphism in anxiety and depression: the Hordaland Homocysteine Study.

Abstract

BACKGROUND

An association between depression and folate status has been demonstrated in clinical studies, whereas data are sparse on the relationship between depression and other components of 1-carbon metabolism such as vitamin B12, homocysteine, and the methylenetetrahydrofolate reductase 677C-->T polymorphism. The relationship between anxiety and these components is less well known. This study examined the associations between folate, total homocysteine, vitamin B12, and the methylenetetrahydrofolate reductase 677C-->T polymorphism, and anxiety and depression in a large population-based study.

METHODS

Anxiety and depression, measured by the Hospital Anxiety and Depression Scale, were assessed in 5948 subjects aged 46 to 49 years (mean, 47.4 years) and 70 to 74 years (mean, 71.9 years) from the Hordaland Homocysteine Study cohort. By means of logistic regression models, anxiety and depression scores were examined in relation to the factors listed above.

RESULTS

Overall, hyperhomocysteinemia (plasma total homocysteine level > or =15.0 micro mol/L [> or =2.02 mg/dL]) (odds ratio, 1.90; 95% confidence interval, 1.11-3.25) and T/T methylenetetrahydrofolate reductase genotype (odds ratio, 1.69; 95% confidence interval, 1.09-2.62), but not low plasma folate or vitamin B12 levels, were significantly related to depression without comorbid anxiety disorder. Plasma folate level was inversely associated with depression only in the subgroup of middle-aged women. None of the investigated parameters showed a significant relationship to anxiety.

CONCLUSION

Our results provide further evidence of a role of impaired 1-carbon metabolism in depression.

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  • Authors+Show Affiliations

    ,

    Department of Public Health and Primary Health Care, Locus for Homocysteine and Related Vitamins, University of Bergen, Norway. ingvar.bjelland@uib.no

    , , ,

    Source

    Archives of general psychiatry 60:6 2003 Jun pg 618-26

    MeSH

    Aged
    Anxiety Disorders
    Cohort Studies
    Cross-Sectional Studies
    Depressive Disorder
    Folic Acid
    Genotype
    Homocysteine
    Humans
    Logistic Models
    Male
    Methylenetetrahydrofolate Reductase (NADPH2)
    Middle Aged
    Norway
    Odds Ratio
    Oxidoreductases Acting on CH-NH Group Donors
    Personality Inventory
    Polymorphism, Genetic
    Risk Factors
    Vitamin B 12

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    12796225

    Citation

    Bjelland, Ingvar, et al. "Folate, Vitamin B12, Homocysteine, and the MTHFR 677C->T Polymorphism in Anxiety and Depression: the Hordaland Homocysteine Study." Archives of General Psychiatry, vol. 60, no. 6, 2003, pp. 618-26.
    Bjelland I, Tell GS, Vollset SE, et al. Folate, vitamin B12, homocysteine, and the MTHFR 677C->T polymorphism in anxiety and depression: the Hordaland Homocysteine Study. Arch Gen Psychiatry. 2003;60(6):618-26.
    Bjelland, I., Tell, G. S., Vollset, S. E., Refsum, H., & Ueland, P. M. (2003). Folate, vitamin B12, homocysteine, and the MTHFR 677C->T polymorphism in anxiety and depression: the Hordaland Homocysteine Study. Archives of General Psychiatry, 60(6), pp. 618-26.
    Bjelland I, et al. Folate, Vitamin B12, Homocysteine, and the MTHFR 677C->T Polymorphism in Anxiety and Depression: the Hordaland Homocysteine Study. Arch Gen Psychiatry. 2003;60(6):618-26. PubMed PMID: 12796225.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Folate, vitamin B12, homocysteine, and the MTHFR 677C->T polymorphism in anxiety and depression: the Hordaland Homocysteine Study. AU - Bjelland,Ingvar, AU - Tell,Grethe S, AU - Vollset,Stein Emil, AU - Refsum,Helga, AU - Ueland,Per Magne, PY - 2003/6/11/pubmed PY - 2003/7/15/medline PY - 2003/6/11/entrez SP - 618 EP - 26 JF - Archives of general psychiatry JO - Arch. Gen. Psychiatry VL - 60 IS - 6 N2 - BACKGROUND: An association between depression and folate status has been demonstrated in clinical studies, whereas data are sparse on the relationship between depression and other components of 1-carbon metabolism such as vitamin B12, homocysteine, and the methylenetetrahydrofolate reductase 677C-->T polymorphism. The relationship between anxiety and these components is less well known. This study examined the associations between folate, total homocysteine, vitamin B12, and the methylenetetrahydrofolate reductase 677C-->T polymorphism, and anxiety and depression in a large population-based study. METHODS: Anxiety and depression, measured by the Hospital Anxiety and Depression Scale, were assessed in 5948 subjects aged 46 to 49 years (mean, 47.4 years) and 70 to 74 years (mean, 71.9 years) from the Hordaland Homocysteine Study cohort. By means of logistic regression models, anxiety and depression scores were examined in relation to the factors listed above. RESULTS: Overall, hyperhomocysteinemia (plasma total homocysteine level > or =15.0 micro mol/L [> or =2.02 mg/dL]) (odds ratio, 1.90; 95% confidence interval, 1.11-3.25) and T/T methylenetetrahydrofolate reductase genotype (odds ratio, 1.69; 95% confidence interval, 1.09-2.62), but not low plasma folate or vitamin B12 levels, were significantly related to depression without comorbid anxiety disorder. Plasma folate level was inversely associated with depression only in the subgroup of middle-aged women. None of the investigated parameters showed a significant relationship to anxiety. CONCLUSION: Our results provide further evidence of a role of impaired 1-carbon metabolism in depression. SN - 0003-990X UR - https://www.unboundmedicine.com/medline/citation/12796225/full_citation L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=12796225.ui DB - PRIME DP - Unbound Medicine ER -