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High expression of steroid sulfatase mRNA predicts poor prognosis in patients with estrogen receptor-positive breast cancer.
Clin Cancer Res. 2003 Jun; 9(6):2288-93.CC

Abstract

PURPOSE

Prognostic significance of the intratumoral mRNA expression of three enzymes related to in situ estrogen biosynthesis, i.e., aromatase, sulfatase, and 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1), was evaluated in patients with invasive breast cancer.

EXPERIMENTAL DESIGN

Aromatase, sulfatase, and 17beta-HSD1 mRNA levels in tumor tissues (n = 181) and normal breast tissues (n = 34) were examined by a quantitative, real-time PCR assay and compared with various clinicopathological factors as well as prognosis.

RESULTS

The sulfatase mRNA levels, but not the aromataseor 17beta-HSD1 mRNA levels, were significantly associated with lymph node metastases (P < 0.005), histological grade III (P < 0.001), and poor prognosis (P < 0.005). The association between the sulfatase mRNA and poor prognosis was found to be significant (P < 0.001) only in patients with estrogen receptor (ER)-positive tumors but not in ER negative tumors. In ER-positive tumors, the sulfatase mRNA levels was a significant prognostic factor independent of the lymph node status and histological grade by multivariate analysis.

CONCLUSIONS

The sulfatase mRNA levels can serve as a significant, independent prognostic factor only in ER-positive tumors. It is speculated that the up-regulation of sulfatase mRNA levels leads to a high intratumoral estrogen concentration and, thus, an enhanced stimulation of tumor growth through ERs.

Authors+Show Affiliations

Department of Surgical Oncology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12796397

Citation

Miyoshi, Yasuo, et al. "High Expression of Steroid Sulfatase mRNA Predicts Poor Prognosis in Patients With Estrogen Receptor-positive Breast Cancer." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, vol. 9, no. 6, 2003, pp. 2288-93.
Miyoshi Y, Ando A, Hasegawa S, et al. High expression of steroid sulfatase mRNA predicts poor prognosis in patients with estrogen receptor-positive breast cancer. Clin Cancer Res. 2003;9(6):2288-93.
Miyoshi, Y., Ando, A., Hasegawa, S., Ishitobi, M., Taguchi, T., Tamaki, Y., & Noguchi, S. (2003). High expression of steroid sulfatase mRNA predicts poor prognosis in patients with estrogen receptor-positive breast cancer. Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 9(6), 2288-93.
Miyoshi Y, et al. High Expression of Steroid Sulfatase mRNA Predicts Poor Prognosis in Patients With Estrogen Receptor-positive Breast Cancer. Clin Cancer Res. 2003;9(6):2288-93. PubMed PMID: 12796397.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High expression of steroid sulfatase mRNA predicts poor prognosis in patients with estrogen receptor-positive breast cancer. AU - Miyoshi,Yasuo, AU - Ando,Akiko, AU - Hasegawa,Seiichi, AU - Ishitobi,Makoto, AU - Taguchi,Tetsuya, AU - Tamaki,Yasuhiro, AU - Noguchi,Shinzaburo, PY - 2003/6/11/pubmed PY - 2004/1/7/medline PY - 2003/6/11/entrez SP - 2288 EP - 93 JF - Clinical cancer research : an official journal of the American Association for Cancer Research JO - Clin Cancer Res VL - 9 IS - 6 N2 - PURPOSE: Prognostic significance of the intratumoral mRNA expression of three enzymes related to in situ estrogen biosynthesis, i.e., aromatase, sulfatase, and 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1), was evaluated in patients with invasive breast cancer. EXPERIMENTAL DESIGN: Aromatase, sulfatase, and 17beta-HSD1 mRNA levels in tumor tissues (n = 181) and normal breast tissues (n = 34) were examined by a quantitative, real-time PCR assay and compared with various clinicopathological factors as well as prognosis. RESULTS: The sulfatase mRNA levels, but not the aromataseor 17beta-HSD1 mRNA levels, were significantly associated with lymph node metastases (P < 0.005), histological grade III (P < 0.001), and poor prognosis (P < 0.005). The association between the sulfatase mRNA and poor prognosis was found to be significant (P < 0.001) only in patients with estrogen receptor (ER)-positive tumors but not in ER negative tumors. In ER-positive tumors, the sulfatase mRNA levels was a significant prognostic factor independent of the lymph node status and histological grade by multivariate analysis. CONCLUSIONS: The sulfatase mRNA levels can serve as a significant, independent prognostic factor only in ER-positive tumors. It is speculated that the up-regulation of sulfatase mRNA levels leads to a high intratumoral estrogen concentration and, thus, an enhanced stimulation of tumor growth through ERs. SN - 1078-0432 UR - https://www.unboundmedicine.com/medline/citation/12796397/High_expression_of_steroid_sulfatase_mRNA_predicts_poor_prognosis_in_patients_with_estrogen_receptor_positive_breast_cancer_ L2 - http://clincancerres.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=12796397 DB - PRIME DP - Unbound Medicine ER -