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Morphology and morphogenesis of severe acute respiratory syndrome (SARS)-associated virus.

Abstract

After infecting the Vero E6 cells by nasal/throat swabs collected from SARS patients, we studied the SARS-associated virus by electron microscopy and molecular biological technique. The results show that the diameter of newly isolated virus is about 50 nm without envelope or 100 nm with envelope. The virus was proved to be a new coronavirus by RT-PCR and it responded positively to convalescent-phase serum specimen from SARS patients, which is the evidence that this new virus is etiologically linked to the outbreak of SARS. The morphogenesis and distribution of the virus are also discussed in this article.

Authors+Show Affiliations

State Key Lab for Biocontrol, Zhongshan University, Guangzhou 510275, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12796822

Citation

Zhang, Qin-Fen, et al. "Morphology and Morphogenesis of Severe Acute Respiratory Syndrome (SARS)-associated Virus." Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica Et Biophysica Sinica, vol. 35, no. 6, 2003, pp. 587-91.
Zhang QF, Cui JM, Huang XJ, et al. Morphology and morphogenesis of severe acute respiratory syndrome (SARS)-associated virus. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2003;35(6):587-91.
Zhang, Q. F., Cui, J. M., Huang, X. J., Lin, W., Tan, D. Y., Xu, J. W., Yang, Y. F., Zhang, J. Q., Zhang, X., Li, H., Zheng, H. Y., Chen, Q. X., Yan, X. G., Zheng, K., Wan, Z. Y., & Huang, J. C. (2003). Morphology and morphogenesis of severe acute respiratory syndrome (SARS)-associated virus. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica Et Biophysica Sinica, 35(6), 587-91.
Zhang QF, et al. Morphology and Morphogenesis of Severe Acute Respiratory Syndrome (SARS)-associated Virus. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2003;35(6):587-91. PubMed PMID: 12796822.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Morphology and morphogenesis of severe acute respiratory syndrome (SARS)-associated virus. AU - Zhang,Qin-Fen, AU - Cui,Jin-Ming, AU - Huang,Xiao-Jun, AU - Lin,Wei, AU - Tan,Dong-Yan, AU - Xu,Jie-Wei, AU - Yang,Yi-Feng, AU - Zhang,Jing-Qiang, AU - Zhang,Xin, AU - Li,Hui, AU - Zheng,Huan-Ying, AU - Chen,Qiu-Xia, AU - Yan,Xin-Ge, AU - Zheng,Kui, AU - Wan,Zhuo-Yue, AU - Huang,Jie-Cheng, PY - 2003/6/11/pubmed PY - 2005/4/2/medline PY - 2003/6/11/entrez SP - 587 EP - 91 JF - Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica JO - Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) VL - 35 IS - 6 N2 - After infecting the Vero E6 cells by nasal/throat swabs collected from SARS patients, we studied the SARS-associated virus by electron microscopy and molecular biological technique. The results show that the diameter of newly isolated virus is about 50 nm without envelope or 100 nm with envelope. The virus was proved to be a new coronavirus by RT-PCR and it responded positively to convalescent-phase serum specimen from SARS patients, which is the evidence that this new virus is etiologically linked to the outbreak of SARS. The morphogenesis and distribution of the virus are also discussed in this article. SN - 0582-9879 UR - https://www.unboundmedicine.com/medline/citation/12796822/Morphology_and_morphogenesis_of_severe_acute_respiratory_syndrome__SARS__associated_virus_ DB - PRIME DP - Unbound Medicine ER -