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Comparative in vitro activity of PH-027 versus linezolid and other anti-anaerobic antimicrobials against clinical isolates of Clostridium difficile and other anaerobic bacteria.
J Chemother. 2003 Apr; 15(2):113-7.JC

Abstract

PH-027 is a new 5-triazole oxazolidinone synthesized in our laboratories, which shows strong activity against gram-positive aerobic bacteria including clinical isolates. The objective of this study was to investigate the in vitro activity of this compound in comparison with linezolid and other antibiotics against gram-positive and gram-negative anaerobes. The in vitro activity of PH-027 in comparison with those of linezolid and other antimicrobial agents was evaluated against 201 clinical isolates of gram-positive and gram-negative anaerobic bacteria by agar dilution and Etest methods. PH-027 showed excellent activity, with minimum inhibitory concentrations (MIC) in the range of 0.12-4.0 microg/ml against all isolates; MIC90s being 4.0, 1.0, 2.0, 2.0 and 2.0 microg/ml against Clostridium difficile, Peptostreptococcus spp., Bacteroides fragilis, Prevotella bivia and Fusobacterium spp. respectively. In comparison, linezolid had MIC in the range of 0.5-4.0 microg/ml against all isolates, with MIC90s of 2.0, 4.0, 4.0, 4.0 and 2.0 microg/ml against the same set of bacteria respectively. PH-027 demonstrated excellent in vitro activity that is superior to linezolid against Peptostreptococcus spp., B. fragilis and P. bivia. However, against C. difficile and Fusobacterium spp, PH-027 and linezolid showed comparable in vitro activity. Against all anaerobes, metronidazole, PH-027 and, to a lesser extent, linezolid had the most potent activity. From the results of in vitro susceptibility testing, both linezolid and PH-027 show promise in the treatment of anaerobic infections.

Authors+Show Affiliations

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kuwait University, Safat, Kuwait. dphillips@hsc.kuniv.edu.kwNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12797385

Citation

Phillips, O A., et al. "Comparative in Vitro Activity of PH-027 Versus Linezolid and Other Anti-anaerobic Antimicrobials Against Clinical Isolates of Clostridium Difficile and Other Anaerobic Bacteria." Journal of Chemotherapy (Florence, Italy), vol. 15, no. 2, 2003, pp. 113-7.
Phillips OA, Rotimi VO, Jamal WY, et al. Comparative in vitro activity of PH-027 versus linezolid and other anti-anaerobic antimicrobials against clinical isolates of Clostridium difficile and other anaerobic bacteria. J Chemother. 2003;15(2):113-7.
Phillips, O. A., Rotimi, V. O., Jamal, W. Y., Shahin, M., & Verghese, T. L. (2003). Comparative in vitro activity of PH-027 versus linezolid and other anti-anaerobic antimicrobials against clinical isolates of Clostridium difficile and other anaerobic bacteria. Journal of Chemotherapy (Florence, Italy), 15(2), 113-7.
Phillips OA, et al. Comparative in Vitro Activity of PH-027 Versus Linezolid and Other Anti-anaerobic Antimicrobials Against Clinical Isolates of Clostridium Difficile and Other Anaerobic Bacteria. J Chemother. 2003;15(2):113-7. PubMed PMID: 12797385.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative in vitro activity of PH-027 versus linezolid and other anti-anaerobic antimicrobials against clinical isolates of Clostridium difficile and other anaerobic bacteria. AU - Phillips,O A, AU - Rotimi,V O, AU - Jamal,W Y, AU - Shahin,M, AU - Verghese,T L, PY - 2003/6/12/pubmed PY - 2003/9/23/medline PY - 2003/6/12/entrez SP - 113 EP - 7 JF - Journal of chemotherapy (Florence, Italy) JO - J Chemother VL - 15 IS - 2 N2 - PH-027 is a new 5-triazole oxazolidinone synthesized in our laboratories, which shows strong activity against gram-positive aerobic bacteria including clinical isolates. The objective of this study was to investigate the in vitro activity of this compound in comparison with linezolid and other antibiotics against gram-positive and gram-negative anaerobes. The in vitro activity of PH-027 in comparison with those of linezolid and other antimicrobial agents was evaluated against 201 clinical isolates of gram-positive and gram-negative anaerobic bacteria by agar dilution and Etest methods. PH-027 showed excellent activity, with minimum inhibitory concentrations (MIC) in the range of 0.12-4.0 microg/ml against all isolates; MIC90s being 4.0, 1.0, 2.0, 2.0 and 2.0 microg/ml against Clostridium difficile, Peptostreptococcus spp., Bacteroides fragilis, Prevotella bivia and Fusobacterium spp. respectively. In comparison, linezolid had MIC in the range of 0.5-4.0 microg/ml against all isolates, with MIC90s of 2.0, 4.0, 4.0, 4.0 and 2.0 microg/ml against the same set of bacteria respectively. PH-027 demonstrated excellent in vitro activity that is superior to linezolid against Peptostreptococcus spp., B. fragilis and P. bivia. However, against C. difficile and Fusobacterium spp, PH-027 and linezolid showed comparable in vitro activity. Against all anaerobes, metronidazole, PH-027 and, to a lesser extent, linezolid had the most potent activity. From the results of in vitro susceptibility testing, both linezolid and PH-027 show promise in the treatment of anaerobic infections. SN - 1120-009X UR - https://www.unboundmedicine.com/medline/citation/12797385/Comparative_in_vitro_activity_of_PH_027_versus_linezolid_and_other_anti_anaerobic_antimicrobials_against_clinical_isolates_of_Clostridium_difficile_and_other_anaerobic_bacteria_ L2 - https://www.tandfonline.com/doi/full/10.1179/joc.2003.15.2.113 DB - PRIME DP - Unbound Medicine ER -