Tags

Type your tag names separated by a space and hit enter

The association of cardiovascular disease with the long-term incidence of age-related maculopathy: the Beaver Dam Eye Study.
Ophthalmology. 2003 Jun; 110(6):1273-80.O

Abstract

PURPOSE

To examine the association between cardiovascular disease and its risk factors and the 10-year incidence of age-related maculopathy.

DESIGN

Population-based cohort study.

PARTICIPANTS

Persons 43 to 86 years of age at baseline examination from 1988 to 1990, living in Beaver Dam, Wisconsin, of whom 3684 persons participated in a 5-year follow-up examination and 2764 participated in a 10-year follow-up examination.

METHODS

Standardized protocols for physical examination, blood collection, administration of a questionnaire, and stereoscopic color fundus photography to determine age-related maculopathy. The Kaplan-Meier (product-limit) survival approach and discrete linear logistic regression were used in the data analysis.

MAIN OUTCOME MEASURES

Incidence and progression of age-related maculopathy.

RESULTS

When age, gender, and history of heavy drinking, smoking, and vitamin use were controlled for, higher systolic blood pressure at baseline was associated with the 10-year incidence of retinal pigment epithelial depigmentation (risk ratio [RR] per 10 mmHg systolic blood pressure, 1.10; 95% confidence interval [CI], 1.01-1.18; P = 0.02) and exudative macular degeneration (RR, 1.22; 95% CI, 1.06-1.41; P = 0.006). Higher pulse pressure at baseline was associated with the incidence of retinal pigment epithelial depigmentation (RR per 10 mmHg, 1.17; 95% CI, 1.07-1.28; P < 0.001), increased retinal pigment (RR, 1.10; 95% CI, 1.01-1.19; P = 0.03), exudative macular degeneration (RR, 1.34; 95% CI, 1.14-1.60; P < 0.001), and progression of age-related maculopathy (RR, 1.08; 95% CI, 1.01-1.17; P = 0.03). Higher serum high-density lipoprotein cholesterol at baseline was associated with pure geographic atrophy (RR per 10 mg/dl high-density lipoprotein cholesterol, 1.29; 95% CI, 1.05-1.58; P = 0.01). Physical activity at baseline was associated with the incidence of geographic atrophy (RR in those who worked up a sweat 5 times a week compared with those who did not, 0.12; 95% CI, 0.02-0.91; P = 0.04) exudative macular degeneration (RR, 0.27; 95% CI, 0.08-0.87; P = 0.05), and progression of age-related maculopathy (RR, 0.69; 95% CI, 0.47-1.00; P = 0.05). Neither a history of stroke nor heart attack was associated with the incidence or progression of age-related maculopathy.

CONCLUSIONS

These findings indicate relationships between higher pulse pressure (a presumed indicator of age-related elastin and collagen changes in Bruch's membrane) and systolic blood pressure with an increased 10-year incidence of some lesions defining early age-related maculopathy and exudative macular degeneration.

Authors+Show Affiliations

Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison 53726, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Corrected and Republished Article
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12799274

Citation

Klein, Ronald, et al. "The Association of Cardiovascular Disease With the Long-term Incidence of Age-related Maculopathy: the Beaver Dam Eye Study." Ophthalmology, vol. 110, no. 6, 2003, pp. 1273-80.
Klein R, Klein BE, Tomany SC, et al. The association of cardiovascular disease with the long-term incidence of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology. 2003;110(6):1273-80.
Klein, R., Klein, B. E., Tomany, S. C., & Cruickshanks, K. J. (2003). The association of cardiovascular disease with the long-term incidence of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology, 110(6), 1273-80.
Klein R, et al. The Association of Cardiovascular Disease With the Long-term Incidence of Age-related Maculopathy: the Beaver Dam Eye Study. Ophthalmology. 2003;110(6):1273-80. PubMed PMID: 12799274.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association of cardiovascular disease with the long-term incidence of age-related maculopathy: the Beaver Dam Eye Study. AU - Klein,Ronald, AU - Klein,Barbara E K, AU - Tomany,Sandra C, AU - Cruickshanks,Karen J, PY - 2003/6/12/pubmed PY - 2003/6/24/medline PY - 2003/6/12/entrez SP - 1273 EP - 80 JF - Ophthalmology JO - Ophthalmology VL - 110 IS - 6 N2 - PURPOSE: To examine the association between cardiovascular disease and its risk factors and the 10-year incidence of age-related maculopathy. DESIGN: Population-based cohort study. PARTICIPANTS: Persons 43 to 86 years of age at baseline examination from 1988 to 1990, living in Beaver Dam, Wisconsin, of whom 3684 persons participated in a 5-year follow-up examination and 2764 participated in a 10-year follow-up examination. METHODS: Standardized protocols for physical examination, blood collection, administration of a questionnaire, and stereoscopic color fundus photography to determine age-related maculopathy. The Kaplan-Meier (product-limit) survival approach and discrete linear logistic regression were used in the data analysis. MAIN OUTCOME MEASURES: Incidence and progression of age-related maculopathy. RESULTS: When age, gender, and history of heavy drinking, smoking, and vitamin use were controlled for, higher systolic blood pressure at baseline was associated with the 10-year incidence of retinal pigment epithelial depigmentation (risk ratio [RR] per 10 mmHg systolic blood pressure, 1.10; 95% confidence interval [CI], 1.01-1.18; P = 0.02) and exudative macular degeneration (RR, 1.22; 95% CI, 1.06-1.41; P = 0.006). Higher pulse pressure at baseline was associated with the incidence of retinal pigment epithelial depigmentation (RR per 10 mmHg, 1.17; 95% CI, 1.07-1.28; P < 0.001), increased retinal pigment (RR, 1.10; 95% CI, 1.01-1.19; P = 0.03), exudative macular degeneration (RR, 1.34; 95% CI, 1.14-1.60; P < 0.001), and progression of age-related maculopathy (RR, 1.08; 95% CI, 1.01-1.17; P = 0.03). Higher serum high-density lipoprotein cholesterol at baseline was associated with pure geographic atrophy (RR per 10 mg/dl high-density lipoprotein cholesterol, 1.29; 95% CI, 1.05-1.58; P = 0.01). Physical activity at baseline was associated with the incidence of geographic atrophy (RR in those who worked up a sweat 5 times a week compared with those who did not, 0.12; 95% CI, 0.02-0.91; P = 0.04) exudative macular degeneration (RR, 0.27; 95% CI, 0.08-0.87; P = 0.05), and progression of age-related maculopathy (RR, 0.69; 95% CI, 0.47-1.00; P = 0.05). Neither a history of stroke nor heart attack was associated with the incidence or progression of age-related maculopathy. CONCLUSIONS: These findings indicate relationships between higher pulse pressure (a presumed indicator of age-related elastin and collagen changes in Bruch's membrane) and systolic blood pressure with an increased 10-year incidence of some lesions defining early age-related maculopathy and exudative macular degeneration. SN - 0161-6420 UR - https://www.unboundmedicine.com/medline/citation/12799274/The_association_of_cardiovascular_disease_with_the_long_term_incidence_of_age_related_maculopathy:_the_Beaver_Dam_Eye_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(03)00599-2 DB - PRIME DP - Unbound Medicine ER -