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[Hyperhomocysteinemia: an independent risk factor or a simple marker of vascular disease? 2. Epidemiological data].
Pathol Biol (Paris) 2003; 51(2):111-21PB

Abstract

Elevated plasma total homocysteine (tHcy) is considered as a risk factor for occlusive cardiovascular disease (CVD). This concept is based on the observations of premature vascular disease in patients with homocystinuria and on the association between tHcy and increased risk of CVD in prospective studies. However, some observations have raised questions about tHcy as a risk factor. First, low risk population based prospective studies tend to indicate a weak association or no association between tHcy and CVD. Second, several traditional risk factors for CVD are associated with tHcy and may confound the relation between tHcy and CVD. Third, the C667T transition of the methylenetetrahydrofolate reductase causes a moderate increase in tHcy but no or only minor increased CVD risk. Thus, only placebo-controlled intervention studies with tHcy-lowering B-vitamins and clinical endpoints can provide additional valid arguments for the debate over whether tHcy is a causal CVD risk factor.

Authors+Show Affiliations

Laboratoire de physiologie, UFR de médecine, BP 87900, 21079 cedex, Dijon, France. jean-claude.guilland@chu-dijon.fr <jean-claude.guilland@chu-dijon.fr>No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

fre

PubMed ID

12801809

Citation

Guilland, J-C, et al. "[Hyperhomocysteinemia: an Independent Risk Factor or a Simple Marker of Vascular Disease? 2. Epidemiological Data]." Pathologie-biologie, vol. 51, no. 2, 2003, pp. 111-21.
Guilland JC, Favier A, Potier de Courcy G, et al. [Hyperhomocysteinemia: an independent risk factor or a simple marker of vascular disease? 2. Epidemiological data]. Pathol Biol. 2003;51(2):111-21.
Guilland, J. C., Favier, A., Potier de Courcy, G., Galan, P., & Hercberg, S. (2003). [Hyperhomocysteinemia: an independent risk factor or a simple marker of vascular disease? 2. Epidemiological data]. Pathologie-biologie, 51(2), pp. 111-21.
Guilland JC, et al. [Hyperhomocysteinemia: an Independent Risk Factor or a Simple Marker of Vascular Disease? 2. Epidemiological Data]. Pathol Biol. 2003;51(2):111-21. PubMed PMID: 12801809.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Hyperhomocysteinemia: an independent risk factor or a simple marker of vascular disease? 2. Epidemiological data]. AU - Guilland,J-C, AU - Favier,A, AU - Potier de Courcy,G, AU - Galan,P, AU - Hercberg,S, PY - 2003/6/13/pubmed PY - 2003/9/3/medline PY - 2003/6/13/entrez SP - 111 EP - 21 JF - Pathologie-biologie JO - Pathol. Biol. VL - 51 IS - 2 N2 - Elevated plasma total homocysteine (tHcy) is considered as a risk factor for occlusive cardiovascular disease (CVD). This concept is based on the observations of premature vascular disease in patients with homocystinuria and on the association between tHcy and increased risk of CVD in prospective studies. However, some observations have raised questions about tHcy as a risk factor. First, low risk population based prospective studies tend to indicate a weak association or no association between tHcy and CVD. Second, several traditional risk factors for CVD are associated with tHcy and may confound the relation between tHcy and CVD. Third, the C667T transition of the methylenetetrahydrofolate reductase causes a moderate increase in tHcy but no or only minor increased CVD risk. Thus, only placebo-controlled intervention studies with tHcy-lowering B-vitamins and clinical endpoints can provide additional valid arguments for the debate over whether tHcy is a causal CVD risk factor. SN - 0369-8114 UR - https://www.unboundmedicine.com/medline/citation/12801809/[Hyperhomocysteinemia:_an_independent_risk_factor_or_a_simple_marker_of_vascular_disease_2__Epidemiological_data]_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0369811403001056 DB - PRIME DP - Unbound Medicine ER -