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Thrombophilic markers in patients with congenital bleeding disorders.
Haematologia (Budap). 2002; 32(4):467-73.H

Abstract

We have studied the presence or absence of thrombophilic markers in 59 patients with congenital bleeding disorders. Theoretically, the coexistence of coagulation factor deficiency and thrombophilia in patients with haemophilia may cause the bleeding tendency to decline. In 8 cases we have found thrombophilic marker positivity, in 7 patients APC resistance and in 1 patient protein S deficiency has been revealed. The presence of thrombophilic markers did not affect the frequency of bleeding episodes or the development of haemophilic arthropathy. The factor concentrate utilization, however, was lower in the group carrying thrombophilic markers, which indicates that the bleeding episodes were less severe. Relying on the strength of these findings, the medicinal influencing of inhibitor mechanisms may present itself as a potential therapy.

Authors+Show Affiliations

Transfusion Department, University of Szeged, Pécsi, u. 4B, H-6720 Szeged, Hungary. kvezendi@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12803120

Citation

Vezendi, K, et al. "Thrombophilic Markers in Patients With Congenital Bleeding Disorders." Haematologia, vol. 32, no. 4, 2002, pp. 467-73.
Vezendi K, Tápai K, Erdödi E, et al. Thrombophilic markers in patients with congenital bleeding disorders. Haematologia (Budap). 2002;32(4):467-73.
Vezendi, K., Tápai, K., Erdödi, E., Szabó, I., Tomek, A., Oszlács, J., & Scheibl, E. (2002). Thrombophilic markers in patients with congenital bleeding disorders. Haematologia, 32(4), 467-73.
Vezendi K, et al. Thrombophilic Markers in Patients With Congenital Bleeding Disorders. Haematologia (Budap). 2002;32(4):467-73. PubMed PMID: 12803120.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thrombophilic markers in patients with congenital bleeding disorders. AU - Vezendi,K, AU - Tápai,K, AU - Erdödi,E, AU - Szabó,I, AU - Tomek,A, AU - Oszlács,J, AU - Scheibl,E, PY - 2003/6/14/pubmed PY - 2003/10/24/medline PY - 2003/6/14/entrez SP - 467 EP - 73 JF - Haematologia JO - Haematologia (Budap) VL - 32 IS - 4 N2 - We have studied the presence or absence of thrombophilic markers in 59 patients with congenital bleeding disorders. Theoretically, the coexistence of coagulation factor deficiency and thrombophilia in patients with haemophilia may cause the bleeding tendency to decline. In 8 cases we have found thrombophilic marker positivity, in 7 patients APC resistance and in 1 patient protein S deficiency has been revealed. The presence of thrombophilic markers did not affect the frequency of bleeding episodes or the development of haemophilic arthropathy. The factor concentrate utilization, however, was lower in the group carrying thrombophilic markers, which indicates that the bleeding episodes were less severe. Relying on the strength of these findings, the medicinal influencing of inhibitor mechanisms may present itself as a potential therapy. SN - 0017-6559 UR - https://www.unboundmedicine.com/medline/citation/12803120/Thrombophilic_markers_in_patients_with_congenital_bleeding_disorders_ DB - PRIME DP - Unbound Medicine ER -